Ohbo Kazuyuki

オオボカズユキ | Ohbo Kazuyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www-user.yokohama-cu.ac.jp/~finemorp/

Research field (4)： Medical biochemistry , Systems genomics , Genomics , Anatomy

Research keywords (9)： lung development , Germ cell development , 自己複製 , 幹細胞 , エピジェネティクス , regenerative medicine , self-renew , Stem cell , Epigenetics

Research theme for competitive and other funds (15)：

2022 - 2024 Effects of paternal histone modification integrated in undifferentiated spermatogonial during early embryogenesis
2019 - 2023 Analysis of epigenome infertiity mechanism by the state-of-art single cell and ultrtrace histone modification methods
2019 - 2023 Identification and dynamic analysis of true stem cells in testicular stem cells using the latest single cell analysis method
2020 - 2022 Effects of histone modification primed in spermatogonia stem cells on the next generation totipotency program
2015 - 2018 International joint research on gamete formation through the cutting-edge analysis system

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Papers (51)：

Michio Ono, Kuniko Nakajima, Shin-ichi Tomizawa, Takayuki Shirakawa, Ippei Okada, Hirotomo Saitsu, Naomichi Matsumoto, Kazuyuki Ohbo. Spatial and temporal expression analysis of BMP signal modifiers, Smoc1 and Smoc2, from postnatal to adult developmental stages in the mouse testis. Gene Expression Patterns. 2024
Shin-Ichi Tomizawa, Rachel Fellows, Michio Ono, Kazushige Kuroha, Ivana Dočkal, Yuki Kobayashi, Keisuke Minamizawa, Koji Natsume, Kuniko Nakajima, Ikue Hoshi, et al. A non-canonical bivalent gene Wfdc15a controls spermatogenic protease and immune homeostasis. Development (Cambridge, England). 2024
Shin-Ichi Tomizawa, Kazushige Kuroha, Michio Ono, Kuniko Nakajima, Kazuyuki Ohbo. A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia. Asian journal of andrology. 2024
Hiromi Fukuda, Daisuke Yamaguchi, Kristofor Nyquist, Yasushi Yabuki, Satoko Miyatake, Yuri Uchiyama, Kohei Hamanaka, Ken Saida, Eriko Koshimizu, Naomi Tsuchida, et al. Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing. Clinical Epigenetics. 2021. 13. 1. 204-204
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, et al. Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing. Development. 2021. 148. 10

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MISC (8)：

富澤信一, 小林裕貴, PETERS Antoine H.F.M., ANASTASSIADIS Konstantinos, STEWART A Francis, 関真秀, 鈴木穣, CLARK Stephen, KELSEY Gavin, 大保和之. 精子幹細胞分化系列におけるエピジェネティックおよびトランスクリプトームの解析. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
久保直樹, 藤英博, 白根健次郎, 白川峰征, 小林久人, 佐藤哲也, 曾根秀利, 佐藤康人, 富澤信一, 鶴崎美徳, et al. 新生仔マウスの精原幹細胞の形成と分化における全ゲノムDNAメチル化およびトランスクリプトーム解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0606]-[1P0606]
OBO KAZUYUKI. エピジェネティクスの視点から見た精原幹細胞分化. 日本生殖医学会雑誌. 2015. 60. 1/2. 89
OBO KAZUYUKI. 生殖細胞からみた幹細胞の分化制御システム. 横浜医学. 2013. 64. 1. 13-19
Shin-Ichi Yamashita, Keita Tokuishi, Toshihiko Moroga, Takafumi Hashimoto, Mirei Kamei, Shuji Suehiro, Kiyoshi Ono, Satoshi Yamamoto, Masao Chujo, Kazuyuki Ohbo, et al. HE4 EXPRESSION IS ASSOCIATED WITH WORSE PROGNOSIS IN PULMONARY ADENOCARCINOMA. JOURNAL OF THORACIC ONCOLOGY. 2011. 6. 6. S972-S973

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Lectures and oral presentations (23)：

精子幹細胞分化を制御するエピジェネティックな機構の解析
(第129回日本解剖学会総会・全国学術総会 2024)
エピジェネティックチェックポイントの精子幹細胞分化における意義について
(第4回有性生殖研究会 2024)
精子幹細胞におけるプライミング機構により制御されているWfdc15aの精子形成における役割
(日本遺伝学95回大会 2023)
Spermatogonial chromatin priming for spermiogenic and post-fertilization development
(2023)
Role of a novel protease inhibitor for spermatogenesis and immune homeostasis
(2023)

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Association Membership(s) (3)：

JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS , JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY , THE JAPANESE ASSOCIATION OF ANATOMISTS

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