Research keywords (8):
Netherton syndrome
, atopic dermatitis
, psoriasis
, LEKTI
, kallikrein-related peptidases
, antimicrobial peptides
, epidermal keratinocytes
, Innate immunity in the skin
Research theme for competitive and other funds (11):
2023 - 2026 Elucidation of the pathogenesis of Netherton syndrome using model mice
2023 - 2026 高深度プロテオーム解析による悪性黒色腫血中腫瘍マーカーの探索と臨床応用
2023 - 2026 Mechanisms of reciprocal regulation of immune diseases by EBI3-containing heterodimer cytokines
2020 - 2023 乾癬病変部表皮角化細胞産生EBI3含有サイトカインに関する研究
2016 - 2018 the elucidation of complication mechanism in patients with recessive dystrophic epidermolysis bullosa (RDEB)
2014 - 2017 The analysis of regulation of serine protease inhibitors expression in epidermal keratinocytes
2012 - 2015 Studies on host immune responses induced by reactivation of EB virus-infected lymphocytes and resultant skin lesions
2012 - 2014 The effect of aberrant expression of kallikrein 7 induced by Th2 cytokines on epidermal barrier
2011 - 2013 Investigation of expression regulation and pathological mechanism of Panton-valentine leukocidine in skin
2010 - 2011 Preferable biological milieu for the growth of viral epithelial neoplasms and its regulation
2010 - 2011 An effect of Th2 environment on kallikrein expression in keratinocytes and skin barrier
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Papers (145):
Masaki Takiwaki, Hiroshi Umemura, Yoshikuni Kikutani, Seketsu Fukuzawa, Kentaro Abe, Kiyotaka Fujino, Satoru Sugihara, Kota Tachibana, Shin Morizane, Mamoru Satoh, et al. A method for measuring serum levels of melanin-associated indole metabolites using LC-MS/MS and its application to malignant melanoma. Clinica chimica acta; international journal of clinical chemistry. 2024. 117873-117873
Yoshio Kawakami, Ai Kajita, Ken-Ichi Hasui, Yoshihiro Matsuda, Keiji Iwatsuki, Shin Morizane. Elevated expression of interleukin-6 (IL-6) and serum amyloid A (SAA) in the skin and the serum of recessive dystrophic epidermolysis bullosa: Skin as a possible source of IL-6 through Toll-like receptor ligands and SAA. Experimental Dermatology. 2024. 33. 3
Mana Usui-Taniguchi, Yoshio Kawakami, Yoichiro Toi, Tatsuya Kaji, Yoshiko Matsuura, Emi Yokoyama, Tomoko Miyake, Yoji Hirai, Shin Morizane. Pruritic folliculitis of pregnancy with granular deposition of immunoglobulin G along the basement membrane zone. The Journal of dermatology. 2023