Nishiyama Akira

ニシヤマアキラ | Nishiyama Akira

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www-user.yokohama-cu.ac.jp/~immunol/

Research field (1)： Medical biochemistry

Research keywords (6)： molecular biology , transcription factor , hematopoiesis , omics analysis , immunology , gene expression

Research theme for competitive and other funds (15)：

2023 - 2025 転写因子・液-液相分離依存性クロマチンドメインによる免疫細胞分化制御
2021 - 2024 Comprehensive analysis of multifactorial interactions that construct the transcription unity mechanism
2021 - 2024 Higher-order chromatin structure dynamics during dendritic cell development in vivo
2019 - 2022 Development of locus-specific single cell analysis of chromatin modifications in tissue
2018 - 2020 Evaluation of a cell lineage determination model that converts genomic distances into stochasticity

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Papers (63)：

Takaya Yamasaki, Akira Nishiyama, Nagomi Kurogi, Koutarou Nishimura, Shion Nishida, Daisuke Kurotaki, Tatsuma Ban, Jordan A. Ramilowski, Keiko Ozato, Atsushi Toyoda, et al. Physical and functional interaction among Irf8 enhancers during dendritic cell differentiation. Cell Reports. 2024. 43. 4. 114107-114107
Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, et al. Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis. eLife. 2023
Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, et al. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Reports. 2023. 42. 3. 112165-112165
Toshiaki Ito, Masami Ohta, Atsuki Osada, Akira Nishiyama, Kei-Ichiro Ishiguro, Tomohiko Tamura, Yoichi Sekita, Tohru Kimura. Switching defective/sucrose non-fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline. Genes to cells : devoted to molecular & cellular mechanisms. 2022
Daisuke Kurotaki, Kenta Kikuchi, Kairong Cui, Wataru Kawase, Keita Saeki, Junpei Fukumoto, Akira Nishiyama, Kisaburo Nagamune, Keji Zhao, Keiko Ozato, et al. Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 34. e2207009119

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Lectures and oral presentations (20)：

単核貪食細胞分化におけるDNAメチル化に着目したエピゲノム解析
(第26回造血器腫瘍研究会 2024)
エンハンサー群の協調機構が樹状細胞分化に必須の転写因子IRF8の発現を最適化する
(第46回日本分子生物学会年会 2023)
Transcriptional regulation of mononuclear phagocyte development by the transcription factor IRF8
(JSPS-NIH forum 2022)
RUNX-CBFβによって駆動されるIrf8 エンハンサーが単球か樹状細胞かの系譜選択を決定する
(第44回日本分子生物学会年会 2021)
A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
(2021)

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Education (3)：

1994 - 1999 Kyoto university Postgraduate course of Medicine
1992 - 1994 Kyoto prefectural university Postgraduate course of Agricultural science
1988 - 1992 kyoto prefectural university Faculty of agriculture Department of agriculture

Professional career (1)：

博士(医学) (京都大学)

Work history (4)：

2010 - 現在 Yokohama City University
2007 - 2010 National Institute of Health National Institute on Aging Research associate
2005 - 2006 National Institute of Health National Institute of Child Health and Human Development Research fellow
2000 - 2005 National Institute of Health National Institute of Child Health and Human Development Visiting fellow

Association Membership(s) (4)：

THE JAPANESE SOCIETY OF HEMATOLOGY , JAPANESE SOCIETY FOR IMMUNOLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本エピジェネティクス研究会

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