2019 - 2022 Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system
2016 - 2019 Establishment of a motivated behavior assessment system for long-term administration of Kampo medicine and application of Kampo medicine in treating apathy
2014 - 2016 Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's disease
2013 - 2015 アルツハイマー病発症機構の解明
2012 - 2015 Elucidation of the role of chronic inflammation underlying pathogenesis of Alzheimer's disease
2011 - 2012 Establishment and application of novel type of Alzheimer's disease model mouse
2011 - 2012 Establishment of the diagnostics of Alzheimer' s disease using A・43
2009 - 2010 ネプリライシンを中軸とするアルツハイマー病予防・治療のための創薬標的の探索
2007 - 2009 Generation and application of the novel mouse model for Alzheimer's disease
2005 - 2006 ソマトスタチンによるアミロイドβ分解酵素ネプリライシンの活性制御機構の解明
2003 - 2004 アミロイドβ分解酵素ネプリライシンの発現及び活性制御機構の解明
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Papers (212):
Shingo Ito, Yumi Iwata, Mitsumi Otsuka, Yui Kaneko, Seiryo Ogata, Ryotaro Yagi, Tatsuki Uemura, Takeshi Masuda, Takashi Saito, Takaomi Saido, et al. Progressive Amyloid-β Accumulation in the Brain leads to Altered Protein Expressions in the Liver and Kidneys of APP knock-in Mice. Journal of pharmaceutical sciences. 2024
Stephanie R Miller, Kevin Luxem, Kelli Lauderdale, Pranav Nambiar, Patrick S Honma, Katie K Ly, Shreya Bangera, Mary Bullock, Jia Shin, Nick Kaliss, et al. Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models. Cell reports. 2024. 43. 11. 114870-114870
Nicholas Sweeney, Tae Yeon Kim, Cody T Morrison, Liangping Li, Diana Acosta, Jiawen Liang, Nithin V Datla, Julie A Fitzgerald, Haoran Huang, Xianglan Liu, et al. Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway. Acta neuropathologica. 2024. 148. 1. 52-52
Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, et al. Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab. Life Science Alliance. 2024. 7. 12. e202402650-e202402650
Akira Uruno, Shiori Kadoguchi-Igarashi, Ritsumi Saito, Shohei Koiso, Daisuke Saigusa, Ching-Tung Chu, Takafumi Suzuki, Takashi Saito, Takaomi C Saido, Antonio Cuadrado, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice. Journal of biochemistry. 2024
Multifactorial glial responses and their contributions to Alzheimer’s disease (AD) continuum (From accurate pathological modeling to application)
(University of Zurich特別講演 2023)
Role of glial response underlying pathogenesis of Alzheimer’s disease
(The 1st Fujita International Symposium on Brain Science 2022)