Ikeguchi Mitsunori

イケグチミツノリ | Ikeguchi Mitsunori

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.tsurumi.yokohama-cu.ac.jp/bioinfo/

Research field (3)： Biological, health, and medical informatics , Bio-, chemical, and soft-matter physics , Biophysics

Research keywords (3)：バイオインフォマティクス , 分子シミュレーション , 生物物理学

Research theme for competitive and other funds (21)：

2018 - 2023 生体発動分子の機能発現に関する構造ダイナミクス研究
2013 - 2016 Molecular simulation study on the rotation mechanism of V-ATPase
2011 - 2013 Pループ型ATP加水分解酵素の機能発現機構の解明
2011 - 2012 Structure-function relationships of Rad51-Swi5-Sfr1 complex for homologous recombination
2010 - 2012 Study on rotation mechanisms of F1 molecular motor using molecular simulations

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Papers (212)：

Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R H Tame, et al. Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. Nature communications. 2023. 14. 1. 7150-7150
Tsutomu Yamane, Takahiro Nakayama, Toru Ekimoto, Masao Inoue, Keigo Ikezaki, Hiroshi Sekiguchi, Masahiro Kuramochi, Yasuo Terao, Ken Judai, Minoru Saito, et al. Comparison of the Molecular Motility of Tubulin Dimeric Isoforms: Molecular Dynamics Simulations and Diffracted X-ray Tracking Study. International Journal of Molecular Sciences. 2023. 24. 20. 15423-15423
Hideaki Ohtomo, Tsutomu Yamane, Takashi Oda, Noriyuki Kodera, Jun-ichi Kurita, Yasuo Tsunaka, Romain Amyot, Mitsunori Ikeguchi, Yoshifumi Nishimura. Dynamic solution structures of whole human NAP1 dimer bound to one and two histone H2A-H2B heterodimers obtained by integrative methods. Journal of Molecular Biology. 2023. 168189-168189
Yukiko Kurihara, Toru Ekimoto, Christopher T Gordon, Yasunobu Uchijima, Ryo Sugiyama, Taro Kitazawa, Akiyasu Iwase, Risa Kotani, Rieko Asai, Véronique Pingault, et al. Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding. The Journal of clinical investigation. 2023. 133. 4
Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto, Masaki Yamamoto, Mitsunori Ikeguchi, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nature Communications. 2023. 14. 1

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MISC (83)：

Nagata T, Yamada T, Hayashi T, Hikiri S, Kobayashi N, Ikeguchi M, Katahira M, Kinoshita M, Yanagawa H. STRUCTURAL AND PHYSICAL BASIS FOR THE HIGHER AFFINITY TO ONCOPROTEIN MDM2 OF A PEPTIDE SELECTED WITH MRNA DISPLAY OVER TUMOR SUPPRESSOR P53. 64th Annual Meeting of the Biophysical Society, San Diego, 2020.2.15-19. 2020
浴本亨, 小甲裕一, 苙口友隆, 池口満徳, 池口満徳. X線小角散乱と分子動力学シミュレーションを組み合わせた生体分子の溶液構造解析. アンサンブル. 2020. 22. 3
田中翼, 下地恵令奈, 永友芽里, 山根努, 浴本亨, 根谷崎牧子, 大井里香, 池口満徳, 禾晃和. In vitroとin silicoの融合によるセマフォリン-プレキシンペアの結合特異性決定因子の探索. 日本細胞生物学会大会(Web). 2019. 71st
田中翼, 永友芽里, 根谷崎牧子, 大井里香, 下地恵令奈, 山根努, 浴本亨, 池口満徳, 禾晃和. シグナル分子セマフォリンと受容体プレキシンの結合特異性に関する構造生物学的解析. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
Takashi Yoshidome, Yuki Sekiguchi, Tomotaka Oroguchi, Masayoshi Nakasako, Mitsunori Ikeguchi. Reconstruction of Three-Dimensional Structures of a Protein with Software ENMA and EMC Algorithm: A Simulation for XFEL-CXDI Experiment. BIOPHYSICAL JOURNAL. 2017. 112. 3. 288A-288A

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Books (4)：

実験医学増刊構造生命科学で何がわかるのか何ができるのか
羊土社 2014
Protein Conformational Dynamics
Springer Cham Heidelberg New York Dordrecht London 2014
1分子ナノバイオ計測
化学同人 2014
最新分子マシンナノで働く“高度な機械”を目指して
化学同人 2008

Lectures and oral presentations (97)：

Finite-size effect on the charging free energy in the alchemical perturbation and “Warp Drive” method
(Biophysical society 62th Annual Meeting 2018)
In silico binding affinity analysis for phosphodiesterase-10A inhibitors
(情報計算科学生物学会2017年大会 2017)
In silico protein design for functional modification of the photoactivated adenylate cyclase
(情報計算科学生物学会2017年大会 2017)
Finite-size effect on the charging free energy in the alchemical perturbation and ``warp drive'' method
(情報計算科学生物学会2017年大会 2017)
Apo- and antagonist-binding structures of vitamin D receptor ligand-binding domain elucidated by SAXS experiments and MD simulations
(第55回日本生物物理学会年会 2017)

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Education (2)：

- 1994 The University of Tokyo
- 1989 The University of Tokyo The Faculty of Engineering Department of Mathematical Engineering and Information Physics

Professional career (1)：

博士(農学) (東京大学)

Work history (2)：

Yokohama City University International College of Arts and Sciences Medical Life Science Graduate School of Medical Life Science Department of Medical Life Science Professor
東京大学農学部助手

Association Membership(s) (4)：

米国生物物理学会 , 日本物理学会 , 日本蛋白質科学会 , 日本生物物理学会

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