Hamada Keisuke

ハマダケイスケ | Hamada Keisuke

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www-user.yokohama-cu.ac.jp/~seika/index.html

Research field (1)： Structural biochemistry

Research keywords (2)：構造生物学 , X線結晶構造解析

Research theme for competitive and other funds (11)：

2024 - 2027 ペプチド創薬に応用可能なペプチドプレニル基転移酵素群の構造生物学的解析
2021 - 2024 トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明
2018 - 2021 Study of the mechanism of nucleosome-enhanceosome conversion
2016 - 2019 Search for anti-leukemic drugs targeting the cancer-related transcription factor Runx1/CBFbeta
2012 - 2017 Regulation mechanism of a transcription cycle by static/dynamic structural analyses

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Papers (35)：

Alexander A Vinogradov, Yue Zhang, Keisuke Hamada, Shunsuke Kobayashi, Kazuhiro Ogata, Toru Sengoku, Yuki Goto, Hiroaki Suga. A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. Journal of the American Chemical Society. 2024. 146. 12. 8058-8070
Shuhei Onishi, Kotone Uchiyama, Ko Sato, Chikako Okada, Shunsuke Kobayashi, Keisuke Hamada, Tomohiro Nishizawa, Osamu Nureki, Kazuhiro Ogata, Toru Sengoku. Structure of the human Bre1 complex bound to the nucleosome. Nature communications. 2024. 15. 1. 2580-2580
Yasuhiro Utsuno, Keisuke Hamada, Kohei Hamanaka, Keita Miyoshi, Keiji Tsuchimoto, Satoshi Sunada, Toshiyuki Itai, Masamune Sakamoto, Naomi Tsuchida, Yuri Uchiyama, et al. Novel missense variants cause intermediate phenotypes in the phenotypic spectrum of SLC5A6-related disorders. Journal of Human Genetics. 2023. 69. 2. 69-77
Yuchen Zhang, Keisuke Hamada, Masayuki Satake, Toru Sengoku, Yuki Goto, Hiroaki Suga. Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases. Journal of the American Chemical Society. 2023
Annalisa Vetro, Cristiana Pelorosso, Simona Balestrini, Alessio Masi, Sophie Hambleton, Emanuela Argilli, Valerio Conti, Simone Giubbolini, Rebekah Barrick, Gaber Bergant, et al. Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration. The American Journal of Human Genetics. 2023. 110. 8. 1356-1376

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MISC (3)：

M. Kato, H. Saitsu, T. Mizuguchi, H. Osaka, J. Tohyama, K. Uruno, S. Kumada, K. Hamada, A. Nishimura, S. Hirai, et al. CLINICAL SPECTRUM OF OHTAHARA SYNDROME CAUSED BY STXBP1 MUTATION. EPILEPSIA. 2009. 50. 16-17
浜田恵輔, 箱嶋敏雄. 接着分子・受容体へ集積する蛋白質の構造研究 (特集大きな構造フレームで捉えるシグナル伝達). 蛋白質核酸酵素. 2001. 46. 13. 1929-1935
HAMADA Keisuke, HAKOSHIMA Toshio. The Interaction of ERM Proteins with Membranes and Adhesion Proteins: X-Ray Structural Studies of the Radixin FERM Domain. Seibutsu Butsuri. 2001. 41. 5. 230-234

Lectures and oral presentations (3)：

Structural basis for the substrate recognition of a peptide histidine prenyltransferase
(Annual Meeting of the Protein Science Society of Japan 2022)
トリプトファンプレニル基転移酵素の結晶構造解析
(日本生化学会年会 2019)
ヒストンシャペロンNap1の構造解析
(日本生化学会年会 2014)

Education (2)：

1996 - 2001 Nara Institute of Science and Technology Graduate School of Biological Sciences
- 2001 Nara Institute of Science and Technology Graduate School, Division of Biological Science Division of Cell Biology

Work history (3)：

Association Membership(s) (2)：

日本生化学会 , 日本蛋白質科学会

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