Rchr

J-GLOBAL ID：201201063900939790 Update date: Jun. 20, 2024

NAGATOISHI Satoru

ナガトイシサトル | NAGATOISHI Satoru

Affiliation and department：
Job title： Associate Professor
Other affiliations (1)：

The University of Tokyo School of Engineering Associate Professor

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/30550248.ja.html

Research field (7)： Pharmaceuticals - chemistry and drug development , Functional biochemistry , Analytical chemistry , Biophysics , Pharmaceuticals - analytical and physicochemistry , Biochemistry , Applied biofunctional and bioprocess engineering

Research keywords (13)： Protein Engineering , Biophysical chemistry , Biophysical Methods , Biomolecular Interactions , Drug screening , Antibody Engineering , Protein Science , Intrinsically Disordered Protein , Nucleic Acid Chemistry , Thermodynamics , Kinetics , Solvent Effect , Molecular Crowding

Research theme for competitive and other funds (25)：

2022 - 2026 Identification of tumor driver lncRNAs in myeloid tumors and development of lncRNA-targeting therapies
2021 - 2025 次世代抗体医薬品の実用化に向けた品質評価及び管理手法に関する技術的研究
2020 - 2024 ミトコンドリア先制医療
2020 - 2023 Elucidation and Control of Local Fractions in Protein Engineering
2021 - 2023 感染症B細胞レパトア解析のための計算・情報基盤の構築

2019 - 2022 Targeting transcription and epigenetic factors through modulation of protein-protein interactions

2016 - 2022 がん細胞・がん間質細胞特異的な酸素センシング機構を標的としたがん微小環境標的薬剤の開発

2018 - 2022 発動分子を合理設計・理論計算するための物理化学評価と構造基盤の確立

2017 - 2021 リード創製を指向した物理化学的品質評価技術の開発と支援

2018 - 2020 蛋白質の弱い相互作用トリガーシステムの解明とその設計提案

2017 - 2019 Development of species-specific anti-bacterial therapeutic agents based on molecular interaction

2016 - 2019 Screening and design of ligands regulating the process of protein-protein interactions based on biophysical approaches

2016 - 2019 Functional analysis and development for anti-tumor compounds targeted PRDM14 relating to cancer stemness based on protein-protein interaction

2017 - 2019 進行肺がん大規模クリニカルシークエンスデータを用いた個別化治療法の開発

2017 - 2019 薬剤により誘導される過渡的構造を基盤としたキナーゼ阻害薬活用研究

2015 - 2018 Elucidation of the mechanism underlying the formation of neuromuscular synapse

2013 - 2018 Dynamics of Molecular Pattern Recognition in Protein Interaction

2017 - 2018 分子間インタラクションに基づく細菌種に特異的な創薬基盤の開発

2015 - 2018 新規アミノ酸を用いた高親和性・高安定性VHH抗体の作製技術の開発

2015 - 2017 Design of protein binders based on the activation energy of interaction

2013 - 2016 Ligand discovery based on biophysical analyses

2012 - 2014 Physicochemical studies of YB-1 functions and structures

2009 - 2014 分子クラウディング環境を活用した遺伝子発現系で活躍する機能性分子のデザイン・開発システムの構築

2010 - 2011 Analyses of Protein Folding Codon affecting protein functions

2007 - 2008 四本鎖構造形成DNAと蛋白質間相互作用の精密解析

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Papers (122)：

Risa Asano, Miyu Takeuchi, Makoto Nakakido, Sho Ito, Chihiro Aikawa, Takeshi Yokoyama, Akinobu Senoo, Go Ueno, Satoru Nagatoishi, Yoshikazu Tanaka, et al. Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA. Protein science : a publication of the Protein Society. 2024. 33. 6. e5017
Megumi Hoya, Ryo Matsunaga, Satoru Nagatoishi, Teruhiko Ide, Daisuke Kuroda, Kouhei Tsumoto. Impact of single-residue mutations on protein thermal stability: The case of threonine 83 of BC2L-CN lectin. International journal of biological macromolecules. 2024. 132682-132682
Sawako Goto, Akihisa Tsutsumi, Yongchan Lee, Michihiro Hosojima, Hideyuki Kabasawa, Koichi Komochi, Satoru Nagatoishi, Kazuya Takemoto, Kouhei Tsumoto, Tomohiro Nishizawa, et al. Cryo-EM structures elucidate the multiligand receptor nature of megalin. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 22. e2318859121
Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, et al. A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2. Chemical science. 2024. 15. 19. 7051-7060
Tatsuki Akabane, Nobuhiro Suzuki, Kazuyoshi Ikeda, Tomoki Yonezawa, Satoru Nagatoishi, Hiroyoshi Matsumura, Takuya Yoshizawa, Wataru Tsuchiya, Satoshi Kamino, Kouhei Tsumoto, et al. THOUSAND-GRAIN WEIGHT 6, which is an IAA-glucose hydrolase, preferentially recognizes the structure of the indole ring. Scientific reports. 2024. 14. 1. 6778

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MISC (40)：

長門石曉, 津本浩平. 次世代抗体. 炎症と免疫. 2023. 31. 4. 82-85
中木戸誠, 小菅啓史, 長門石曉, 福田哲也, 板東泰彦, VEGA Susana, 大沼信一, 津本浩平, 津本浩平. 腫瘍抑制蛋白質PRELPのマルチバレント相互作用を介した機能制御. 日本生化学会大会(Web). 2023. 96th
小菅啓史, 中木戸誠, 中木戸誠, DE VEGA Susana, 長門石曉, 福田哲也, 板東泰彦, 大沼信一, 津本浩平, 津本浩平, et al. 細胞外マトリクスへの局在を介した多重特異性蛋白質PRELPの低親和性相互作用の制御機構の解析. 日本生化学会大会(Web). 2023. 96th
長門石曉, 木下清晶, 小菅啓史, 黒田大祐, 黒田大祐, 木吉真人, 石井明子, 寺尾陽介, 井出輝彦, 津本浩平. 固定化FcγRIIIaリガンドの抗体認識機構の解明. 日本生化学会大会(Web). 2023. 96th
山口貴世志, 中川沙弥, 大河原悠哉, 高根希世子, 池上恒雄, 秦裕子, 尾山大明, 長門石曉, 津本浩平, 愛甲丞, et al. Regulation and function of BRD8, a subunit of the TIP60 HAT complex, in colorectal cancer cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd

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Patents (1)：

抗カドヘリン17抗体及び胃がん体外イメージング剤

Books (15)：

分光法シリーズ医薬品開発のための分光法
講談社 2022 ISBN:9784065295823
品質評価のカギをにぎるバイオ医薬品の分析法知っておきたい基礎×一歩進んだ応用
じほう 2022 ISBN:9784840754606
創薬研究のためのスクリーニング学実践テキスト
羊土社 2022 ISBN:9784758122580
実験医学別冊創薬研究のための相互作用解析パーフェクト
羊土社 2021 ISBN:9784758122566
機器分析ハンドブック 2 高分子・分離分析編
化学同人 2020 ISBN:9784759820225

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Lectures and oral presentations (72)：

Raman spectroscopic analysis for conformational characterization of high-concentration antibody solutions
(第24回日本蛋白質科学会年会 2024)
HDX-MSによる溶液中の抗体ダイナミクス解析
(第72回質量分析総合討論会 2024(日本質量分析学会) 2024)
バイオ医薬品開発において押さえておきたい安定性評価
(PHARM TECH JAPAN ONLINE WEBセミナー 2024)
蛋白質相互作用解析と創薬
(日本薬学会第144年会 2024)
Vaccine Antigen and Antibody Protein Engineering
(The Joint 24th International Conference on Emerging Infectious Diseases in the Pacific Rim of the U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 2024)

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Education (3)：

2006 - 2009 The University of Tokyo Graduate School of Frontier Sciences
2004 - 2006 Kyushu University Graduate School of Engineering Department of Chemistry and Biochemistry
2000 - 2004 Kyushu University School of Engineering Department of Materials Science and Engineering

Professional career (1)：

PhD of Life Science (The University of Tokyo)

Work history (11)：

2023/04 - 現在 The University of Tokyo Department of Bioengineering, Department of Chemistry & Biotechnology, School of Engineering Associate Professor (Concurrent)
2023/04 - 現在 The University of Tokyo Medical Device Development and Regulation Research Center, School of Engineering Associate Professor
2021/12 - 2023/03 National Institutes of Biomedical Innovation, Health and Nutrition Adjunct Project Leader (Concurrent)
2017/04 - 2023/03 The University of Tokyo The Institute of Medical Science Project Associate Professor
2017/04 - 2023/03 The University of Tokyo The Graduate School of Engineering Project Associate Professor (Concurrent)

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Committee career (7)：

2023/04 - 現在日本熱測定学会委員
2016 - 現在日本薬学会構造活性相関部会幹事
2016 - 現在日本化学会化学と工業誌編集幹事委員
2024 - 日本化学会生体機能関連化学部会 ISBC2024 Scientific program committee
2020/07 - 2023/06 新化学技術推進協会技術顧問

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Awards (9)：

2023/07 - 日本生化学会 2023 JB審査員賞(JB reviewer award)
2022/03 - 日本化学会第102春季年会若い世代の特別講演証
2021/10 - 日本熱測定学会 2021年度日本熱測定学会奨励賞
2020/04 - バイオアナリシスフォーラム第11回JBFシンポジウム Good Collaboration Award
2015/09 - SAR Presentation Award

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Association Membership(s) (8)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE CHEMICAL SOCIETY OF JAPAN , 日本熱測定学会 , 日本質量分析学会 , アメリカ生物物理学会

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