Atsushi Kawaguchi

カワグチアツシ | Atsushi Kawaguchi

Affiliation and department：
Homepage URL (2)： http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/ , http://www.md.tsukuba.ac.jp/basic-med/kawaguchilab/

Research field (1)： Virology

Research theme for competitive and other funds (15)：

2022 - 2025 ウイルス感染病態を決定する炎症性臓器環境の形成原理の解明
2022 - 2025 高齢者気道組織を再現する動物モデルを用いた肺炎発症機構の解明と診断法への応用
2021 - 2024 Elucidation of molecular mechanism of sex difference in pathogenecity of COVID-19
2020 - 2023 GTP代謝制御によるウイルス複製阻害技術の開発
2019 - 2022 Host range restriction and pathogenicity of influenza virus determined by respiratory epithelial inflammation

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Papers (67)：

Julian Breidenbach, Rabea Voget, Yaoyao Si, Alexandra Hingst, Tobias Claff, Katharina Sylvester, Valentina Wolf, Vesa Krasniqi, Abibe Useini, Norbert Sträter, et al. Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. Journal of medicinal chemistry. 2024. 67. 11. 8757-8790
Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa E Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, et al. Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS chemical biology. 2024. 19. 5. 1028-1034
Ying-Chu Lin, Kenly Wuputra, Kohsuke Kato, Chia-Chen Ku, Shigeo Saito, Michiya Noguchi, Yukio Nakamura, Michael Hsiao, Chang-Shen Lin, Deng-Chyang Wu, et al. Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1. Environmental pollution (Barking, Essex : 1987). 2024. 347. 123722-123722
Mikako Hirohama, Shun Yamashita, Masamitsu N. Asaka, Takahiro Kuroki, Atsushi Kawaguchi. Intramolecular interaction of NEP regulated by CRM1 ensures the unidirectional transport of M1 for the nuclear export of influenza viral ribonucleoprotein. Frontiers in Virology. 2023. 3
Chengyuan Ji, Yao Zhang, Yiqiu Feng, Xinqin Zhang, Jiale Ma, Zihao Pan, Atsushi Kawaguchi, Huochun Yao. Systematic Surveillance of an Emerging Picornavirus among Cattle and Sheep in China. Microbiology spectrum. 2023. 11. 3. e0504022

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MISC (5)：

広川貴次, 川口敦史, 藤井健, 小池智, 朴三用, 夏目徹, 永田恭介, 田中啓二. IT創薬による抗インフルエンザ薬開発. 東京都立産業技術研究センター研究成果発表会要旨集. 2014. 2014. June
浅賀正充, 川口敦史, 永田恭介. ポリコーム複合体因子であるEZH2はインフルエンザウイルスタンパク質M1およびインフルエンザウイルスゲノムの核外輸送を制御する. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th
浅賀正充N., 川口敦史, 永田恭介. EZH2はインフルエンザウイルスゲノムの核外輸送を制御する. 日本分子生物学会年会プログラム・要旨集(Web). 2012. 35th
Kanako Sugiyama, Eiji Obayashi, Atsushi Kawaguchi, Yukari Suzuki, Jeremy R. H. Tame, Kyosuke Nagata, Sam-Yong Park. Structure of PB1-PB2 subunit interface of inflenza A virus RNA polymerase. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C411-C412
Hisashi Yoshida, Eiji Obayashi, Atsushi Kawaguchi, Kyosuke Nagata, Jeremy R. H. Tame, Sam-Yong Park. The structural basis for the essential PA-PB1 subunit interaction in influenza RNA polymerase. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C413-C413

Patents (2)：

コロナウイルスの感染を予防又は治療するための医薬組成物
消毒組成物、洗浄組成物、防汚組成物、ウイルス不活性化組成物および非殺菌性組成物並びにバイオフィルムの除去および形成抑制用組成物

Lectures and oral presentations (11)：

Cohort study of SNP variants that determine the infection risk against SARS-CoV-2
(2021)
Lipid kinase PI5P4K-dependent early multiplication mechanism of influenza virus and coronavirus
(2021)
Chemical genetics study for understanding sex differences in SARS-CoV-2 replication
(2021)
Influenza viral budozone formation in concert with vesicular transport of viral genome ensures functional integrity of virions for immune evasion
(2021)
Airway epithelial tissue inflammatory response by MxA inflammasome to influenza virus infection.
(2021)

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Education (2)：

2003 - 2007 University of Tsukuba Graduate School of Comprehensive Human Sciences
2001 - 2003 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Department of Biological Information

Work history (8)：

2020/01 - 現在 University of Tsukuba Faculty of Medicine Professor
2018/04 - 2019/12 University of Tsukuba Faculty of Medicine
2012/04/01 - 2018/03 University of Tsukuba Faculty of Medicine Assistant Professor
2009/04/01 - 2012/03/31 the Japan Society for the Promotion of Science Research Fellow
2009/04 - 2012/03 Kitasato University Graduate School of Infectioncontrol Sciences

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Awards (1)：

2016/10 - 日本ウイルス学会杉浦奨励賞

Association Membership(s) (2)：

The Molecular Biology Society of Japan , THE JAPANESE SOCIETY FOR VIROLOGY

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