Rchr
J-GLOBAL ID：201201065914198249
Update date: Jul. 08, 2023
Atsushi Kawaguchi
カワグチ アツシ | Atsushi Kawaguchi
Affiliation and department：
Homepage URL (2)：
http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/
,
http://www.md.tsukuba.ac.jp/basic-med/kawaguchilab/
Research field (1)：
Virology
Research theme for competitive and other funds (15)：
- 2022 - 2025 ウイルス感染病態を決定する炎症性臓器環境の形成原理の解明
- 2022 - 2025 高齢者気道組織を再現する動物モデルを用いた肺炎発症機構の解明と診断法への応用
- 2021 - 2024 Elucidation of molecular mechanism of sex difference in pathogenecity of COVID-19
- 2020 - 2023 GTP代謝制御によるウイルス複製阻害技術の開発
- 2019 - 2022 Host range restriction and pathogenicity of influenza virus determined by respiratory epithelial inflammation
- 2018 - 2022 The quality control of viral particles through the endocytic transport of viral genome
- 2017 - 2018 ウイルスゲノム複製酵素を標的とした耐性株が産生されにくい抗インフルエンザ薬の開発
- 2017 - 2018 Respiratory epithelium-specific inflammatory response against influenza virus infection
- 2017 - 2018 インフルエンザウイルスの感染現象を規定する細胞機能の解明
- 2016 - 2017 ウイルスゲノム複製酵素を標的とした耐性株が産生されにくい抗インフルエンザ薬の開発
- 2012 - 2017 Host cell competnecy for negative-stranded RNA viruses
- 2014 - 2016 Molecular mechanism of centrosome activation regulated by influenza virus infection
- 2012 - 2014 Identification of novel host factors responsible for the functional regulation of influenza virus ribonucleoprotein complexes
- 2009 - 2011 インフルエンザウイルスのゲノム複製に視点をおいた細胞特異性及び宿主域解析
- 2006 - 2007 インフルエンザウイルスのゲノム機能により規定される細胞特異性及び宿主域の解析
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Papers (62)：
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Bálint Hajdu, Éva Hunyadi-Gulyás, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata, Béla Gyurcsik. Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2023
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Masumi Iijima, Atsushi Kawaguchi, Yukino Ogura, Ryotaro Yoshimoto, Moemi Kaneda, Kota Kera, Shun'ichi Kuroda, Tsutomu Nakayama. Nano-visualization of the in vitro antiviral activity of black tea based on production area using a liposome-based virus membrane model. Bioscience, biotechnology, and biochemistry. 2022. 86. 12. 1658-1669
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Rikito Murata, Shota Kinoshita, Kenshiro Matsuda, Atsushi Kawaguchi, Akira Shibuya, Kazuko Shibuya. G307S DNAM-1 Mutation Exacerbates Autoimmune Encephalomyelitis via Enhancing CD4+ T Cell Activation. Journal of immunology (Baltimore, Md. : 1950). 2022
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Yukino Ogura, Norihiko Ohbayashi, Yasunori Kanaho, Atsushi Kawaguchi, Yuji Funakoshi. Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking. The Journal of biological chemistry. 2022. 298. 9. 102335-102335
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Takahiro Kuroki, Tomohisa Hatta, Tohru Natsume, Nobuaki Sakai, Akira Yagi, Kohsuke Kato, Kyosuke Nagata, Atsushi Kawaguchi. ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation. mBio. 2022. 13. 3. e0072122
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MISC (5)：
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広川貴次, 川口敦史, 藤井健, 小池智, 朴三用, 夏目徹, 永田恭介, 田中啓二. IT創薬による抗インフルエンザ薬開発. 東京都立産業技術研究センター研究成果発表会要旨集. 2014. 2014. June
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浅賀正充, 川口敦史, 永田恭介. ポリコーム複合体因子であるEZH2はインフルエンザウイルスタンパク質M1およびインフルエンザウイルスゲノムの核外輸送を制御する. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th
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浅賀正充N., 川口敦史, 永田恭介. EZH2はインフルエンザウイルスゲノムの核外輸送を制御する. 日本分子生物学会年会プログラム・要旨集(Web). 2012. 35th
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Kanako Sugiyama, Eiji Obayashi, Atsushi Kawaguchi, Yukari Suzuki, Jeremy R. H. Tame, Kyosuke Nagata, Sam-Yong Park. Structure of PB1-PB2 subunit interface of inflenza A virus RNA polymerase. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C411-C412
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Hisashi Yoshida, Eiji Obayashi, Atsushi Kawaguchi, Kyosuke Nagata, Jeremy R. H. Tame, Sam-Yong Park. The structural basis for the essential PA-PB1 subunit interaction in influenza RNA polymerase. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C413-C413
Patents (2)：
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コロナウイルスの感染を予防又は治療するための医薬組成物
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消毒組成物、洗浄組成物、防汚組成物、ウイルス不活性化組成物および非殺菌性組成物並びにバイオフィルムの除去および形成抑制用組成物
Lectures and oral presentations (11)：
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Cohort study of SNP variants that determine the infection risk against SARS-CoV-2
(2021)
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Lipid kinase PI5P4K-dependent early multiplication mechanism of influenza virus and coronavirus
(2021)
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Chemical genetics study for understanding sex differences in SARS-CoV-2 replication
(2021)
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Influenza viral budozone formation in concert with vesicular transport of viral genome ensures functional integrity of virions for immune evasion
(2021)
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Airway epithelial tissue inflammatory response by MxA inflammasome to influenza virus infection.
(2021)
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Education (2)：
- 2003 - 2007 University of Tsukuba Graduate School of Comprehensive Human Sciences
- 2001 - 2003 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Department of Biological Information
Work history (8)：
- 2020/01 - 現在 University of Tsukuba Faculty of Medicine Professor
- 2018/04 - 2019/12 University of Tsukuba Faculty of Medicine
- 2012/04/01 - 2018/03 University of Tsukuba Faculty of Medicine Assistant Professor
- 2009/04/01 - 2012/03/31 the Japan Society for the Promotion of Science Research Fellow
- 2009/04 - 2012/03 Kitasato University Graduate School of Infectioncontrol Sciences
- 2008/04 - 2009/03 University of Tsukuba
- 2007/04 - 2008/03 日本学術振興会 特別研究員 PD
- 2006/04 - 2007/03 日本学術振興会 特別研究員 DC2
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Awards (1)：
Association Membership(s) (2)：
The Molecular Biology Society of Japan
, THE JAPANESE SOCIETY FOR VIROLOGY
