Research theme for competitive and other funds (13)：
2021 - 2024 Testing the "serotonin hypothesis of depression" by in vivo genome editing
2021 - 2024 Testing the hypothesis that impaired hippocampal function and increased depressive-like behavior are due to reduced serotonin synthesis in the median raphe nucleus
2019 - 2021 セロトニン神経系の光操作・観察によるモデルベース的意思決定の脳内機構解明
2018 - 2021 Elucidation of the serotonergic pathways underlying emotional functions using optogenetics and genome editing
2016 - 2019 Elucidation of neural mechanisms underlying fear memory using DREADD
2016 - 2018 Challenge for establishing tools to knock out 5-HT receptor genes using CRISPR/Cas9
2013 - 2017 Testing serotonin hypothesis of depression with optogenetics
2014 - 2016 光遺伝学による「モデルベース」の意思決定とセロトニン神経系の関係の解明
2014 - 2016 児童青年期におけるセロトニン神経系と衝動的行動の関係の解明
2014 - 2016 Novel neural mechanisms of active control for the monoaminergic/cholinergic release
2012 - 2014 オプトジェネティクスによる正中縫線核セロトニン神経と衝動性の関係の解明
2011 - 2014 Functional develpment of 5-HT/GABA neurons in the raphe nuclei - postnatal stress and epigenetics
2011 - 2012 SSRI administration during adolescent period and suicide risk-serotonin receptors and impulsivity
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Papers (62)：
Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, et al. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nature Communications. 2022. 13. 1
Youcef Bouchekioua, Mao Nebuka, Hitomi Sasamori, Naoya Nishitani, Chiaki Sugiura, Masaaki Sato, Mitsuhiro Yoshioka, Yu Ohmura. Serotonin 5-HT2C receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning. Translational psychiatry. 2022. 12. 1. 58-58
Yu Ohmura, Youcef Bouchekioua, Hiroyuki Kawai, Kazuki Nagayasu, Shuji Kaneko. Increased neuronal activity of serotonin neurons in the median raphe nucleus attenuates reward-related consummatory responses and facial expression. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 2-B
Youcef Bouchekioua, Naoya Nishitani, Yu Ohmura. Conditioned Lick Suppression: Assessing Contextual, Cued, and Context-cue Compound Fear Responses Independently of Locomotor Activity in Mice. BIO-PROTOCOL. 2022. 12. 23
