KURIHARA Shin

クリハラシン | KURIHARA Shin

Affiliation and department：

Research field (2)： Bacteriology , Applied microbiology

Research keywords (8)： predominant human intestinal bacteria , prebiotics , Enterococcus faecalis , quorum sensing , Proteus mirabilis , polyamine , E. coli , Intestinal bacteria

Research theme for competitive and other funds (21)：

2023 - 2027 New strategy for preventing colorectal cancer by targeting polyamines, which are thought to be carcinogens
2023 - 2026 Establishment of technology for intestinal polyamine production by combining non-digestible peptides and bacteria from fermented foods.
2023 - 2026 大豆由来難消化性ペプチドを用いたヒト腸内常在菌叢の改善技術の開発と健康への応用
2023 - 2025 Analysis of the association between polyamine production in the scalp bacterial flora and hair growth.
2021 - 2024 腸内細菌叢が関与する食品中機能性成分の抱合代謝物動態の総合的理解

2021 - 2023 寿命を延ばす腸内細菌とその代謝産物の同定

2021 - 2023 Development of an innovative strategy to control gut microbes using indigestible peptides

2020 - 2023 Optimization of polyamine levels in the intestinal tract by controlling gut microbiota using lactic acid bacteria from traditional fermented foods

2021 - 2022 大豆由来難消化性ペプチドが腸内常在菌のポリアミン産生に及ぼす影響の解析

2019 - 2021 ノトバイオート蝿を用いた健康寿命の腸内細菌による延伸効果の解析

2017 - 2020 ヒト腸内細菌最優勢種の腸管内腔におけるポリアミン生産機構の遺伝学的解析

2017 - 2019 Elucidation of host-intestinal microbial symbiosis mechanism formed by aromatic amines

2016 - 2019 食品成分の腸内細菌変換による健康増進効果の遺伝学的解析

2015 - 2018 Human milk oligosaccharides as the bifidus factor: the mechanism underlying how bifidus flora is established in infant guts

2016 - 2018 ポリアミン合成系遺伝子を操作した腸内細菌を導入したノトバイオートマウスによるヒトと腸内細菌の相互作用の解析

2016 - 2018 家庭用プリンタでプリントアウトして作成する酵素法によるポリアミンセンサーの開発

2016 - 2016 Identification of novel genes encoding enzymes responsible for polyamine biosynthesis of Bacteroides thetaiotaomicron, the dominant intestinal bacterium of human.

2015 - 2016 健康増進物質ポリアミンの高生産に関わる腸内細菌優勢菌種のスクリーニングとその生産機構の解明

2014 - 2016 腸内細菌学の明日を切り開く新規シンビオジェニック因子の探索

2011 - 2013 尿路感染症菌プロテウス・ミラビリスの病原型分化におけるポリアミンの役割の解明

2007 - 2009 ポリアミンを指標にした腸内微生物群制御による腸内環境コントロール

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Papers (67)：

Wataru Matsumoto, Miho Takemura, Haruka Nanaura, Yuta Ami, Takashi Maoka, Kazutoshi Shindo, Shin Kurihara, Norihiko Misawa. Carotenoid productivity in human intestinal bacteria Eubacterium limosum and Leuconostoc mesenteroides with functional analysis of their carotenoid biosynthesis genes. Engineering Microbiology. 2024. 4. 2. 100147-100147
Yuna Miyajima, Shigehiro Karashima, Ren Mizoguchi, Masaki Kawakami, Kohei Ogura, Kazuhiro Ogai, Aoi Koshida, Yasuo Ikagawa, Yuta Ami, Qiunan Zhu, et al. Prediction and causal inference of hyperuricemia using gut microbiota. Scientific reports. 2024. 14. 1. 9901-9901
Bin Li, Jue Liang, Hamid R Baniasadi, Shin Kurihara, Margaret A Phillips, Anthony J Michael. Functional identification of bacterial spermine, thermospermine, norspermine, norspermidine, spermidine, and N1-aminopropylagmatine synthases. The Journal of biological chemistry. 2024. 107281-107281
Rika Hirano, Izumi Nishita, Riho Nakai, Ayaka Bito, Ryunosuke Sasabe, Shin Kurihara. Development of culture methods capable of culturing a wide range of predominant species of intestinal bacteria. Frontiers in Cellular and Infection Microbiology. 2023. 13. 1056866
Yuta Ami, Narumi Kodama, Masahiro Umeda, Hanae Nakamura, Hideto Shirasawa, Takashi Koyanagi, Shin Kurihara. Levilactobacillus brevis with high production of putrescine isolated from blue cheese and its application. International Journal of Molecular Sciences. 2023. 24. 11. 9668

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MISC (30)：

杉山友太, 栗原新. 腸内細菌由来フェネチルアミンによる宿主セロトニン産生の促進. バイオサイエンスとインダストリー. 2023. 81. 4. 305-307
栗原新. Analysis of the Effect of Soybean-derived Indigestible Peptides on Polyamine Production by Gut Indigenous Bacteria. 大豆たん白質研究. 2023. 25
栗原新. 産業と行政ポリアミンと健康についての最新事情欧米での研究事例を中心に. バイオサイエンスとインダストリー. 2020. 78. 4. 335-339
Analysis of interaction between host and gut bacteria and host using gnotobiotic mice associated with the intestinal bacteria where the genes responsible for polyamine biosynthesis are manipulated. 2019. 1-10
栗原新. マンパワーを味方につけるラボ運営 (バイオ系のキャリアデザインアカデミア編「ラボ立ち上げました」). 生物工学会誌. 2019. 97. 11. 675-677

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Patents (7)：

末梢セロトニンまたは腸内芳香族アミンの増加を伴う疾患の予防または治療用医薬組成物および末梢セロトニンまたは腸内芳香族アミンの増加を伴う疾患の予防または治療用薬剤のスクリーニング方法
Group media for gut bacteria, and method of culturing gut bacteria
タマリンド分解物、酪酸産生菌増殖促進剤、腸内酪酸産生用組成物、並びに、タマリンド分解物の製造方法
腸内ポリアミン産生剤
サポニンを含む酪酸産生菌増殖能向上組成物、腸内常在菌増殖能向上組成物、乳酸菌増殖能向上組成物及びビフィズス菌増殖能向上組成物

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Books (2)：

微生物資源の整備と利活用の戦略
エヌ・ティー・エス 2023 ISBN:9784860438586
醸造の事典 = Encyclopedia of jozo
朝倉書店 2021 ISBN:9784254431254

Lectures and oral presentations (196)：

Development of a Sakekasu fermented beverage with a high concentration of polyamines using polyamine-producing lactic acid bacteria derived from fermented food products.
(日本乳酸菌学会誌 2024)
タマリンドシードガム酵素分解物は、ヒト腸内常在酪酸産生菌Roseburia intestinalisを特異的に増殖促進させ腸内の酪酸増加に寄与する
(日本乳酸菌学会誌 2023)
ブルーチーズ由来高ポリアミン産生乳酸菌Levilactobacillus brevis FB215の分離と応用
(日本乳酸菌学会誌 2023)
Intestinal microbes convert arginine, which is a component of the resistant protein, into putrescine.
(2023 Polyamines Conference GRC 2023)
Extension of host lifespan by polyamines derived from gut bacteria
(2023 Polyamines Conference GRC 2023)

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Education (3)：

2003 - 2006 Kyoto University Graduate School of Biostudies
2001 - 2003 Kyoto University Graduate School of Biostudies Applied Life Sciences
1997 - 2001 Kyoto University Faculty of Agriculture

Professional career (1)：

Ph.D. (Life science) (Kyoto University)

Work history (11)：

2021/04 - 現在 Kindai University Faculty of Biology-Oriented Science and Technology Department of Science and Technology on Food Safety Associate Professor
2019/04 - 2021/03 Kindai University Faculty of Biology-Oriented Science and Technology Department of Science and Technology on Food Safety Lecturer
2013/10 - 2019/03 Ishikawa Prefectural University Host-Microbe Interaction Research Lab Associate Professor
2013/09 - 2013/09 Ishikawa Prefectural University Research Institute for Bioresources and Biotechnology Postdoc
2013/03 - 2013/08 University of Texas Southwestern Medical Center, Dallas Department of Pharmacology Visiting Senior Researcher

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Committee career (3)：

2023/07 - 現在 Japan Society for Lactic Acid Bacteria. director
2018/12 - 現在日本ポリアミン学会評議員
2017/05 - 現在日本ポリアミン学会企画運営委員

Awards (11)：

2023/07 - 一般社団法人バイオインダストリー協会バイオインダストリー奨励賞日欧ヒト腸内常在菌叢における最優勢種のハイスループット培養・解析法の開発と応用
2023/04 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Hot Topics Award at Annual Meeting of JSBBA 2023 Intestinal microbes can convert arginine in soy-derived digestion resistant peptide to polyamines.
2020/01 - 日本農芸化学会 2020年度大会トピックス演題選出(発表責任者) 次世代型プレバイオティクス・ガラクトシル-β-1,4-ラムノースのビフィズス菌特異的な増殖促進機構の解析
2019/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Award for Young Scientists Elucidation of polyamine metabolism and transport by the gut microbes
2018/03 - BBB paper award (Corresponding author) Use of Gifu Anaerobic Medium for culturing 32 dominant species of human gut microbes and its evaluation based on short-chain fatty acids fermentation profiles.

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