Shichinohe Hideo

シチノヘヒデオ | Shichinohe Hideo

Affiliation and department：

Research field (2)： Philosophy and ethics , Neurosurgery

Research keywords (28)： Bone marrow stromal cell , Spinal cord injury , Differentiation , Neuroprotection , Cerebral stroke , Migration , 脊髄損傷 , 骨髄間質細胞 , 脳梗塞 , サイトカイン , 中枢神経再生医療 , PET , バイオマテリアル , 光イメージング , 幹細胞移植 , Regenerative medicine , Diffuse axonal injury , 再生医療 , Cerebral infarction , Functional restoration , Regeneration , 機能回復 , transplantation , 脳挫傷 , 脳損傷 , biomaterial , 神経再生 , 抗血管新生因子

Research theme for competitive and other funds (20)：

2020 - 2023 Stem cell combined with scaffold for treating chronic cerebral hemorrhage
2016 - 2019 Development of neuroprotective therapy with selective intra-arterial infusion of cold artificial oxygen carrier
2015 - 2018 Elucidation of the pathology of spinal cord adhesive arachnoiditis and establishment of treatment
2015 - 2018 Investigation of barrier function of endothelial cells derived from moyamoya disease-specific iPS cells
2015 - 2018 Can inflammation worsen the prognosis of severe subarachnoid hemorrhage

2014 - 2018 Nuclear medicine imaging toward therapeutic strategy of atherosclerosis: Experimental research to establish EBM

2015 - 2017 Induction of smooth muscle cells from iPS cells derived from moyamoya disease patient

2013 - 2016 Genome-wide CNV array analysis in parent-offspring pairs with Moyamoya disease with and without clinical anticipation

2013 - 2015 The role of SIRT1 in cellular senescence and characteristics in brain microvascular endothelial cells

2012 - 2015 Analysis for circulating endothelial progenitor cells in moyamoya disease

2011 - 2012 Autologous Bone Marrow Stromal Cell Transplantation for Stroke: Steps to Standardize the Clinical Protocols

2009 - 2011 Comprehensive strategy for neuronal regenerative medicine with human bone marrow stromal cells (BMSC) transplantation

2008 - 2010 Human bone marrow stromal cells transplantation to regenerate central nervous system ; The translational research with novel technologies.

2008 - 2010 Translational Research for Clinical Application of Autologous Bone Marrow Stromal Cell Transplantation for CNS disorders

2005 - 2007 COMPREHENSIVE RESEARCH PROJECT FOR CENTRAL NERVOUS SYSTEM REGENERATION BY BONE MARROW STROMAL CELL TRANSPLANTATION

2005 - 2006 RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM FOCUSED ON AXON EXTENSION FROM THE HOST NEURONS

2005 - 2006 自己骨髄細胞を利用したもやもや病に対する血管新生療法の開発

2004 - 2006 A basic study of gene and anti-angiogenic therapy for malignant brain tumor using bone marrow stromal cell and its potential of cell-fusion

2003 - 2005 RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM USING BIOMATERIALS AND GENE ANALYSIS

2002 - 2005 RESEARCH FOR CELL TRANSPLANTATION THERAPY FOR CEREBRAL INFARCTION AND SPINAL CORD INJURY USING BONE MARROW STROMAL CELLS (BMSC)

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Papers (129)：

Masahito Kawabori, Satoshi Kuroda, Hideo Shichinohe, Kaoru Kahata, Souichi Shiratori, Satoshi Ikeda, Taisuke Harada, Kenji Hirata, Khin Khin Tha, Masato Aragaki, et al. Intracerebral transplantation of MRI-trackable autologous bone marrow stromal cells for patients with subacute ischemic stroke. Med (New York, N.Y.). 2024
Soichiro Takamiya, Masahito Kawabori, Tsukasa Kitahashi, Kentaro Nakamura, Yuki Mizuno, Hironobu Yasui, Yuji Kuge, Aki Tanimori, Yasuyuki Takamatsu, Kohei Yuyama, et al. Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model. Stem Cells International. 2022. 2022. 1-10
Masahito Kawabori, Hideo Shichinohe, Satoshi Kuroda, Kiyohiro Houkin. Intracerebral Transplantation of Autologous Bone Marrow Stem Cell (BMSC) for Subacute Ischemic Stroke, Phase 1 Clinical Trial (RAINBOW Trial). STROKE. 2021. 52
Masahito Kawabori, Aki Tanimori, Shinri Kitta, Hideo Shichinohe, Kiyohiro Houkin. Corrigendum to "Evaluation of Novel Stereotactic Cannula for Stem Cell Transplantation against Central Nervous System Disease". Stem cells international. 2021. 2021. 9796010-9796010
川堀真人, 七戸秀夫, 黒田敏, 宝金清博. 脳梗塞に対する新規治療の開発-血栓回収療法時代のアンメットメディカルニーズと医薬品開発戦略- 主幹動脈閉塞脳梗塞患者に対する幹細胞脳内移植治験(RAINBOW研究). 脳循環代謝. 2020. 32. 1. 52-52

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MISC (121)：

川堀真人, 川堀真人, 七戸秀夫, 七戸秀夫, 黒田敏, 寳金清博. Cell Therapy against CNS Diseases : Current Status and Future Perspectives. 脳神経外科ジャーナル. 2020. 29. 11. 777-783
川堀真人, 七戸秀夫, 黒田敏, 寳金清博. Cell therapy against central nervous disorders - Current and future perspectives -. 神経治療学(Web). 2020. 37. 3
Kawabori Masahito, Shichinohe Hideo, Kuroda Satoshi, Houkin Kiyohiro. Cell therapy against central nervous disorders - Current and future perspectives -. Neurological Therapeutics. 2020. 37. 3. 386-390
川堀真人, 七戸秀夫, 山崎和義, 黒田敏, 寳金清博. 中枢神経疾患に対する細胞治療の現状と今後の展望幹細胞で脳は治るのか?. 脳神経外科ジャーナル. 2019. 28. Supplement. 101
山崎和義, 川堀真人, 関俊隆, 七戸秀夫, 高宮宗一郎, 濱内祝嗣, 寳金清博, 寳金清博. ラット亜急性期脊髄損傷モデルにおける骨髄間葉系幹細胞シートによる治療効果の検証. 日本分子脳神経外科学会プログラム・抄録集. 2019. 20th

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Professional career (1)：

医学博士 (北海道大学)

Work history (8)：

2021/04 - 現在北海道大学大学院文学研究院応用倫理・応用哲学研究教育センター研究員
2021/04 - 現在北海道大学病院医療・ヘルスサイエンス研究開発機構臨床研究監理センター准教授
2020/07 - 現在株式会社RAINBOW 研究開発担当取締役
2017/01 - 2021/03 北海道大学病院臨床研究監理部長准教授
2016/09 - 2016/12 北海道大学病院臨床研究開発センター准教授

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