Ohmi Yuhsuke

オオウミユウスケ | Ohmi Yuhsuke

Affiliation and department：

Research field (1)： Pathobiochemistry

Research keywords (3)：ガングリオシド , シアル酸 , 糖鎖

Research theme for competitive and other funds (14)：

2021 - 2024 Dynamic function analysis of cancer-associated carbohydrate complexes on the cell surface and extracellular vesicles in the generation/secretion and their action
2019 - 2022 Elucidation of pathological mechanisms for an autoantibody and development of therapy for autoimmune diseases
2019 - 2021 Dynamics of microenvironmental regulation by extracellular vesicles with carbohydrates and molecular cluster formation
2018 - 2021 Regulatory mechanisms for signals on cell membrane and under microenvironment by complex of glycosphingolipids and membrane molecules
2018 - 2021 The role of glycosylation of the serum IgG in rheumatoid arthritis

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Papers (61)：

Hiromi Miura, Ayaka Nakamura, Aki Kurosaki, Ai Kotani, Masaru Motojima, Keiko Tanaka, Shigeru Kakuta, Sanae Ogiwara, Yuhsuke Ohmi, Hirotaka Komaba, et al. Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT. BMC Genomics. 2024. 25. 1
Noboru Hashimoto, Shizuka Ito, Akira Harazono, Akiko Tsuchida, Yasuhiro Mouri, Akihito Yamamoto, Tetsuya Okajima, Yuhsuke Ohmi, Keiko Furukawa, Yasusei Kudo, et al. Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance. iScience. 2024. 27. 11. 111139-111139
Mohammad Abul Hasnat, Yuhsuke Ohmi, Farhana Yesmin, Mariko Kambe, Yoshiyuki Kawamoto, Robiul H Bhuiyan, Momoka Mizutani, Noboru Hashimoto, Akiko Tsuchida, Yuki Ohkawa, et al. Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells. Nagoya journal of medical science. 2024. 86. 3. 435-451
Koichi Furukawa, Kogo Takamiya, Yuhsuke Ohmi, Robiul H Bhuiyan, Orie Tajima, Keiko Furukawa. Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene. FEBS open bio. 2023
Farhana Yesmin, Keiko Furukawa, Mariko Kambe, Yuhsuke Ohmi, Robiul Hasan Bhuiyan, Mohammad Abul Hasnat, Momoka Mizutani, Orie Tajima, Noboru Hashimoto, Akiko Tsuchida, et al. Extracellular vesicles released from ganglioside GD2-expressing melanoma cells enhance the malignant properties of GD2-negative melanomas. Scientific reports. 2023. 13. 1. 4987-4987

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MISC (94)：

FURUKAWA Koichi, FURUKAWA Koichi, OHMI Yuhsuke, YESMIN Farhana, YESMIN Farhana, HAMAMURA Kazunori, KONDO Yuji, OHKAWA Yuki, HASHIMOTO Noboru, KANEKO Kei, et al. Roles and action mechanisms of cancer-associated glycolipids. 日本がん免疫学会総会プログラム・抄録集. 2023. 27th
古川鋼一, 橋本登, ILHAMJAN Sabit, 山本朗仁, 大海雄介, 古川圭子. Regulatory mechanisms of cellular function by the interaction between sialic acid-recognizing lectins and recognized sugar chains. Journal of Oral Biosciences Supplement (Web). 2022. 2022
堀内萌々花, 橋本登, 大海雄介, 山本聡子, 北沢裕昭, FARHANA Yesmin, 田島織絵, 古川圭子, 古川鋼一. Analysis of glycolipid expression and function by human colon cancer cells. 日本糖質学会年会要旨集. 2021. 40th
河原敏男, 平松宏明, 大海雄介, 鈴木康夫, 中北愼一, 渡邊洋平, 大野恭秀, 前橋兼三, 小野尭生, 金井康, et al. マウス脳由来細胞におけるインフルエンザウイルス-糖鎖相互作用の解析. 日本薬学会年会要旨集. 2020. 140年会. 28P-am090
大海雄介. IgG上のN型糖鎖改変による新規抗体治療法の検討. 上原記念生命科学財団研究報告集. 2019. 33. 1-4

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Patents (1)：

GD2結合性分子

Books (6)：

糖鎖生物学 : 生命現象と糖鎖情報
名古屋大学出版会 2020 ISBN:9784815809812
Technologies to elucidate functions of glycans
2019
脳内環境辞典
メディカルドゥ 2017 ISBN:9784944157648
Roles of glycosphingolipids in the regulation of the membrane organization and cell signaling in lipid rafts
Nova Science Publishers, Inc. 2016
Beta-1,4 N-Acetylgalactosaminyltransferase 1,2 (B4GALNT1,2)
Springer Japan 2014

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Lectures and oral presentations (7)：

Analysis of proteins interacting with gangliosides in the lipid rafts
(Sialoglyco 2022 2022)
1. Structural and functional analysis of N-glycan binding to autoantibody in rheumatoid arthritis
(2nd Nagoya University - Chittagong University Joint Biochemistry Symposium 2022)
細胞膜糖鎖と近傍分子間で形成される複合体の同定と機能解析
(第 200 回酵母細胞研究会例会 2022)
Ig上のシアル酸機能の解析とSALSA法によるマウス脳組織のシアル化糖鎖構造解析
(第37回日本糖質学会年会 2018)
糖鎖と自己免疫疾患
(第72回NPO法人日本口腔科学会学術集会 2018)

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Education (1)：

2006 - 2010 Nagoya University Graduate School of Medicine

Work history (1)：

2024/04 - 現在 Chubu University College of Life and Health Sciences

Committee career (1)：

2023/04 - 現在日本糖質学会評議員

Awards (4)：

2019/09 - 日本糖質学会第22回日本糖質学会奨励賞
2010/03 - 糖鎖科学名古屋拠点若手研究者奨励賞
2010/02 - 名古屋大学名古屋大学グローバルCOEリサーチアワード
2009/09 - 日本糖質学会第29回日本糖質学会ポスター賞

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