Miyoshi Hiromi

ミヨシヒロミ | Miyoshi Hiromi

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://www.comp.sd.tmu.ac.jp/appliedmechanobio/

Research field (3)： Biomaterials , Biomedical engineering , Biophysics

Research keywords (5)：微細構造化基板 , バイオイメージング , メカノバイオロジー , 細胞極性 , アクチン

Research theme for competitive and other funds (8)：

2024 - 2028 量子ビーム架橋タンパク質ゲルを活用した生体内メカノセンシング機構の追究
2020 - 2023 Foundation of Oil Behavior analyzed by Multiscale Fluid Simulations
2021 - 2022 眼老化・疾患予防の高度化のための調光技術の社会実装に向けた可視光の細胞毒性評価法による基礎的検討
2018 - 2021 Study on the role of the mechanical dynamics in the nucleus in cellular mechanical responses
2015 - 2019 ナノ構造による遺伝情報選択制御の力学機構の理解と幹細胞分化制御への応用展開

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Papers (34)：

Go Uchida, Hitoshi Washizu, Hiromi Miyoshi. Diffusion with a broad class of stochastic diffusion coefficients. Physical Review E. 2024. 109. 6
Hiromi Miyoshi, Masashi Yamazaki, Hiromichi Fujie, Satoru Kidoaki. Guideline for design of substrate stiffness for mesenchymal stem cell culture based on heterogeneity of YAP and RUNX2 responses. Biophysics and Physicobiology. 2023. 20. 2. n/a-n/a
Ryosuke Nishimura, Kagayaki Kato, Misako Saida, Yasuhiro Kamei, Masahiro Takeda, Hiromi Miyoshi, Yutaka Yamagata, Yu Amano, Shigenobu Yonemura. Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids. Cell Structure and Function. 2022. 47. 2. 55-73
Naoya SAKAMOTO, Kohei TATEBAYASHI, Hiromi MIYOSHI. Endothelial differentiation of mesenchymal stem cells induced by the combined mechanical stimulation of wall shear stress and cyclic strain. Transactions of the JSME (in Japanese). 2022. 88. 911. 22-00103-00103
Kojiro Matsushita, Chiharu Nakahara, Shun Kimura, Naoya Sakamoto, Satoshi Ii, Hiromi Miyoshi. Intranuclear mesoscale viscoelastic changes during osteoblastic differentiation of human mesenchymal stem cells. The FASEB Journal. 2021. 35. 12. e22071

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MISC (63)：

Masashi YAMAZAKI, Hiromichi FUJIE, Hiromi MIYOSHI. Mechanical interaction between actin cytoskeleton and nucleus regulates intracellular YAP localization in osteogenic differentiation in human mesenchymal stem cells. Transactions of the JSME (in Japanese). 2020. 86. 890. 20-00264
松下晃次郎, 坂元尚哉, 伊井仁志, 三好洋美. Mechanical Roles of Nuclear Viscoelastic Changes In Osteoblastic Differentiation of Human Mesenchymal Stem Cells. 日本機械学会年次大会講演論文集(CD-ROM). 2020. 2020
YAMAZAKI Masashi, FUJIE Hiromichi, MIYOSHI Hiromi. Changes in the Mechanical Interaction Between Actin Cytoskeleton and Nucleus in Osteogenic Differentiation in Human Mesenchymal Stem Cells. The Proceedings of Mechanical Engineering Congress, Japan. 2020. 2020. S02105
Tomoko Gowa Oyama, Kotaro Oyama, Atsushi Kimura, Fumiya Yoshida, Ryo Ishida, Masashi Yamazaki, Hiromi Miyoshi, Mitsumasa Taguchi. Elasticity and topography-controlled collagen hydrogels mimicking native cellular milieus. bioRxiv. 2019. 706952
松下晃次郎, 坂元尚哉, 伊井仁志, 三好洋美. Quantitative evaluation of nuclear local viscoelasticity in human mesenchymal stem cells during osteogenic differentiation. 日本機械学会年次大会講演論文集(CD-ROM). 2019. 2019

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Patents (13)：

細胞判定方法、スクリーニング方法、細胞分離方法及びゲル
細胞培養用容器、細胞培養用容器の製造方法
細胞培養用基板および間葉系幹細胞の分化制御方法
細胞判定構造体、細胞判定装置、細胞判定方法、及びプログラム
間葉系幹細胞集団の骨芽細胞分化ポテンシャルの予測方法

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Books (3)：

三次元組織モデルの実現に向けた柔軟な培養基材の開発
2022
Smart design of materials for tissue engineering” Smart Materials for Tissue Engineering: Fundamental Principles
Royal Society of Chemistry 2016
Innovative Approaches to Cell Biomechanics: From Cell Migration to On-Chip Manipulation
Springer 2015

Lectures and oral presentations (15)：

Actin cytoskeletal forces to regulate osteoblastic differentiation in mesenchymal stem cell
(2020)
組織・細胞培養基材表面設計の基礎を支えるメカノバイオロジー-間葉系幹細胞の分化に対するアクチン細胞骨格の力の寄与-
(応用物理学会有機分子バイオエレクトロニクス分科会研究会「有機分子・バイオエレクトロニクスの未来を観る」 2018)
Microtopographical cell culture substrate to understand the role of actin cytoskeleton for regulation of gene expression
(The 55th Annual Meeting of The Biophysical Society of Japan 2017)
Change in the intranuclear DNA organization during human mesenchymal stem cell differentiation
(The 3rd Africa International Biotechnology and Biomedical conference 2017)
The Effects of Microgrooved Structures on Cell shape and Actomyosin Organization
(7th International Conference on Computational Methods 2016)

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Education (3)：

2003 - 2006 Tokyo Institute of Technology Department of Life Science and Technology
1998 - 2000 Tokyo Institute of Technology
1994 - 1998 Tokyo Institute of Technology School of Bioscience and Biotechnology

Professional career (1)：

Ph.D. (Tokyo Institute of Technology)

Work history (5)：

2020/04 - 現在 Tokyo Metropolitan University Faculty of Systems Design Associate Professor
2017/04 - 2020/03 Tokyo Metropolitan University Faculty of Systems Design Associate Professor
2016/04 - 2017/03 RIKEN
2007/04 - 2016/03 RIKEN
2006/04 - 2007/03 New Energy and Industrial Technology Development Organization NEDO fellow

Awards (9)：

2023/07 - 第62回日本白内障学会,第49回水晶体研究会セッション優秀賞ヒト水晶体上皮細胞の微細間隙への浸潤性に対する可視域の光の関与
2022/10 - 公益社団法人日本生体医工学会生体医工学シンポジウムベストレビュワーアワード
2021/03 - Analytical Sciences Hot Article Award Analytical Sciences "Designing elastic modulus of cell culture substrate to regulate YAP and RUNX2 localization for controlling differentiation of human mesenchymal stem cells"
2017/03 - 2017 JBSE Graphics of the year award
2017/03 - Journal of Biomechanical Science and Engineering 2017 JBSE papers of the year award

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Association Membership(s) (5)：

THE JAPAN SOCIETY OF MECHANICAL ENGINEERS , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , JAPAN SOCIETY FOR CELL BIOLOGY , THE BIOPHYSICAL SOCIETY OF JAPAN , Biophysical Society

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