Jonghyuk Park, Hiroko Shimbo, Shoko Tamura, Toshifumi Tomoda, Takatoshi Hikida, Haruo Okado, Shinobu Hirai. Impact of feeding age on cognitive impairment in mice with Disrupted-In-Schizophrenia 1 (Disc1) mutation under a high sucrose diet. Behavioural Brain Research. 2025. 476. 115291-115291
Tomoko Tanaka, Shinobu Hirai, Hiroyuki Manabe, Kentaro Endo, Hiroko Shimbo, Yasumasa Nishito, Junjiro Horiuchi, Hikari Yoshitane, Haruo Okado. Minocycline prevents early age-related cognitive decline in a mouse model of intellectual disability caused by ZBTB18/RP58 haploinsufficiency. Journal of neuroinflammation. 2024. 21. 1. 260-260
Shinobu Hirai, Atsuhiro Sakuma, Yasuto Kunii, Hiroko Shimbo, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Rika Kojima, Erika Seki, et al. Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease. Journal of psychiatric research. 2023. 163. 74-79
Sayaka Hirai, Hideki Miwa, Hiroko Shimbo, Keisuke Nakajima, Masahiro Kondo, Tomoko Tanaka, Chiaki Ohtaka-Maruyama, Shinobu Hirai, Haruo Okado. The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment. Molecular psychiatry. 2023
Akiyo Natsubori, Shinobu Hirai, Soojin Kwon, Daisuke Ono, Fei Deng, Jinxia Wan, Momoka Miyazawa, Takashi Kojima, Haruo Okado, Akihiro Karashima, et al. Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle. iScience. 2023. 26. 1. 105830-105830
Investigating the contribution of astrocytic Glut1 to glucose uptake into the brain
(NEURO2024 2024)
Exploration of human GLUT1 promoter and enhancer regions for the development of gene therapy vectors for GLUT1 deficiency syndrome
(NEURO2024 2024)
Elucidation of the involvement of astrocyte function in the pathogenesis of GLUT1 deficiency syndrome
(CINP 35th WORLD CONGRESS 2024)
Involvement of astrocytes in the development of Glucose transporter type 1 deficiency syndrome
(JSNP/JSCNP joint meeting 2024)
Effects of voluntary exercise on cognitive dysfunction and anxiety-like behaviors in a mouse model of psychiatric disorders
(The 101st Annual Meeting of The Physiological Society of Japan 2024)
2007 - 2011 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Track
2005 - 2007 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Track
2001 - 2005 Tokyo University of Agriculture and Technology Faculty of Agriculture Department of Applied Biological Scinece
Work history (6)：
2023/04 - 現在 同研究グループ、グループリーダー、 主席研究員
2022/07 - 現在 Tokyo Metropolitan Institute of Medical Science Brain Metabolic Regulation Group Frontier Laboratory Department of Psychiatry and Behavioral Sciences
2021/04 - 2022/06 Tokyo Metropolitan Institute of Medical Science Sleep Disorders Project senior researcher
2018/04 - 2021/03 Tokyo Metropolitan Institute of Medical Science Neural Development Project senior researcher
2012/04 - 2018/03 Tokyo Metropolitan Institute of Medical Science Neural Development Project Resercher
2011/04 - 2012/03 Tokyo Metropolitan Institute of Medical Science Neural development Project Part- time Researcher
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Awards (7)：
2024/03 - 東京都医学総合研究所 2023年度 理事長表彰
2022/08 - 日本神経精神薬理学会 JSNP Excellent Presentation Award for CINP 2022
2022/06 - 資生堂 第15回『資生堂 女性研究者サイエンスグラント』
2022/03 - 日本統合失調症学会 一般演題賞 奨励賞
2019 - 東京都医学総合研究所所内研究発表会(第1部会・第2部会) 優秀賞
2015 - 東京都医学総合研究所所内研究発表会(第1部会・第2部会) 優秀賞
2011/02 - Tokyo Dental and Medical University Best Poster Award RP58, a negative regulator of Idl-4 genes, controls the population of astrocytes in developing cereberal cortex
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Association Membership(s) (3)：
THE PHYSIOLOGICAL SOCIETY OF JAPAN
, THE JAPAN NEUROSCIENCE SOCIETY
, The Japanese Society of Neuropsychopharmacology
