Research field (8)：
Healthcare management, medical sociology
, Human pathology
, Tumor diagnostics and therapeutics
, Genomics
, General surgery, pediatric surgery
, Environmental effects of chemicals
, Environmental effects of radiation
, Metabolism and endocrinology
2020 - 2023 Molecular diagnosis of rare genetic disorders associated with genome instability
2020 - 2023 ロングリード解析を用いた放射線刻印の同定と福島小児甲状腺癌への応用
2020 - 2023 Molecular pathogenesis of human disorders associated with deficiencies in the DNA repair and environmental stress response systems
2020 - 2022 ロングリード配列決定法による放射線被ばく刻印の同定
2018 - 2020 Establishment of a bio-assay for DNA homologous recombination ability using breast cancer cells to catalog responsible genetic alterations
2017 - 2020 Molecular pathogenesis of human genetic disorders associated with deficiency in the DNA repair and damage response system
2016 - 2020 Can TERT be a marker for prognosis and treatment decision making in thyroid cancer?
2016 - 2020 Molecular epidemiological study of radiation-free pediatric and adolescent thyroid cancers around the Chernobyl area.
2017 - 2019 小児甲状腺がんにおける情報提供と相談支援の体制構築のための研究
2017 - 2019 人工核酸・短鎖ペプチドを用いたゲノム不安定性疾患の新規治療薬開発
2016 - 2019 Molecular epidemiological study of thyroid cancers by international collaboration
2014 - 2019 The molecular epidemiological study of DNA repair-related genes in post-Chernobyl radiation-induced thyroid cancers
2016 - 2018 Establishment of a system to measure DNA repair activity using circulating tumor cells: the key to predict sensitivity to PARP inhibitors
2015 - 2018 Establishment of a synthetic promoter-based system for sensing oncogenic alteration in human live thyroid cells at a single-cell level
2015 - 2018 Molecular epidemiology studies on rare genetic disorders and pediatric cancer cohorts associated with genome instability
2014 - 2018 Elucidation of Prognostic Markers and their Molecular Mechanism for Thyroid Cancer
2014 - 2016 Provocative epidemiological study on identification of factor of thyroid carcinogenesis
2013 - 2016 Molecular Epidemiological Study on Risk of Radiation-associated Cancer after the Chernobyl Nuclear Power Plant accident
2012 - 2015 Do thyroid cancer risk factors FOXE1 and NKX2-1 influence risk of development of a benign adenoma?
2011 - 2015 Identification and functional analysis of novel markers for thyroid cancer stem cells
2011 - 2013 To explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma.
2010 - 2012 Large-scale cohort molecular epidemiological study after the Chernobyl accident
2010 - 2012 Elucidation of molecular mechanism on thyroid carcinogenesis anddevelopmental application of molecular targeting therapy
2009 - 2011 Novel insights into the effect protecting DNA from radiation-induced damage : identification of relevant factors involved in paracrine epithelial-mesenchymal cell interactions
2008 - 2009 Cancer stem cell theory in thyroid carcinogenesis
2007 - 2009 Long-term molecular epidemiological studies on thyroid cancers around Chernobyl
2007 - 2009 Elucidation of thyroid carcinogenesis and clinical application of molecular targeting therapy
2007 - 2008 Elucidation of a novel mechanism of epithelial-mesenchymal cells cross-talk leading to the reduction of radiation-induced DNA damage
2006 - 2007 Patho-physiological Analysis of Radio-resistant Cancer Stem Cells
2006 - 2007 In vivo model mouse study to examine the effect of alteration of endogenous endocrine status in thyroid tumorigenesis
2006 - 2007 甲状腺癌における癌幹細胞の単離同定とその生物学的特性の解析
Show all
Papers (162)：
Ayaka Sako, Michiko Matsuse, Vladimir Saenko, Aya Tanaka, Ryota Otsubo, Michi Morita, Sayaka Kuba, Eijun Nishihara, Keiji Suzuki, Tomoo Ogi, et al. TERT promoter mutations increase tumor aggressiveness by altering TERT mRNA splicing in papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism. 2024
Tetiana Bogdanova, Tatiana I. Rogounovitch, Liudmyla Zurnadzhy, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Serhii Chernyshov, Serhii Gulevatyi, Sergii Masiuk, et al. Characteristics and immune checkpoint status of radioiodine-refractory recurrent papillary thyroid carcinomas from Ukrainian Chornobyl Tissue Bank donors. Frontiers in Endocrinology. 2024. 14. 1343848-1343848
Chikako Senju, Yuka Nakazawa, Taichi Oso, Mayuko Shimada, Kana Kato, Michiko Matsuse, Mariko Tsujimoto, Taro Masaki, Yasushi Miyazaki, Satoshi Fukushima, et al. Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 27. e2217423120
Expression of PD;and PD;in poorly differentiated thyroid carcinoma as;a;means of selecting;patients for immunotherapy T.Rogounovitch, M.Fridman, T.Leonava, V.Kondratovitch, N.Mitsutake, V.Saenko
(The 66th annual Meeting of the Japan Thyroid Association 2023)
Primary tumors and recurrent radioiodine-resistant metastases of PTC have highly concordant immune checkpoint status
(The 66th annual Meeting of the Japan Thyroid Association 2023)
