Rchr
J-GLOBAL ID：201201095608153939
Update date: Jul. 17, 2024
HIRANO Kazumi
ヒラノ カズミ | HIRANO Kazumi
Affiliation and department：
Job title：
主任研究員
Research field (2)：
Developmental biology
, Cell biology
Research keywords (6)：
epigenetics
, brain organoid
, Neural stem cell
, heparan sulfate
, carbohydrate
, pluripotent stem cells
Research theme for competitive and other funds (3)：
- 2018 - 2024 神経疾患創薬を志向した大脳オルガノイドの開発とそれを利用した多検体解析技術の構築
- 2018 - 2020 Development of pericentromere-specific epigenome editing technology and application to new human cerebral development model
- 2015 - 2017 Establishment of drug screening system for mental disorder by generation of novel epigenome editing proteins
Papers (22)：
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Kazutoshi Murotomi, Harumi Kagiwada, Kazumi Hirano, Shoko Yamamoto, Noriaki Numata, Yo Matsumoto, Hidekazu Kaneko, Masakazu Namihira. Cyclo-glycylproline attenuates hydrogen peroxide-induced cellular damage mediated by the MDM2-p53 pathway in human neural stem cells. Journal of cellular physiology. 2023. 238. 2. 434-446
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佐々木 紀彦, 平野 和己, 志智 優樹, 五味 不二也, 吉村 久志, 松下 晃, 板倉 陽子, 豊田 雅士, 石渡 俊行. Gp130/STAT3シグナル伝達は、長鎖ノンコーディングRNAのH19の発現を含む膵臓癌幹細胞の機能を調節する(Gp130/STAT3 signaling modulate pancreatic cancer stem cell feature including long non-coding RNA H19 expression). 日本癌学会総会記事. 2022. 81回. P-2100
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Norihiko Sasaki, Kazumi Hirano, Yuuki Shichi, Fujiya Gomi, Hisashi Yoshimura, Akira Matsushita, Masashi Toyoda, Toshiyuki Ishiwata. Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression. Cancers. 2022. 14. 9
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佐々木 紀彦, 平野 和巳, 志智 優樹, 板倉 陽子, 石渡 俊行, 豊田 雅士. ヒト血管平滑筋細胞の形質転換とガングリオシド. 日本内分泌学会雑誌. 2022. 97. 5. 1517-1517
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Norihiko Sasaki, Kazumi Hirano, Yuuki Shichi, Yoko Itakura, Toshiyuki Ishiwata, Masashi Toyoda. PRC2-dependent regulation of ganglioside expression during dedifferentiation contributes to the proliferation and migration of vascular smooth muscle cells. Frontiers in cell and developmental biology. 2022. 10. 1003349-1003349
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MISC (6)：
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小倉千佳, 平野和己, 佐藤主税, 西原祥子. マウスES細胞の分化時におけるFasシグナル活性化の分子機構. 再生医療. 2015. 14
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Hirano, Kazumi, Nishihara, Shoko. Function of Heparan Sulfate in Pluripotent Stem Cells. Trends in Glycoscience and Glycotechnology. 2014. 26. 152. 149-157
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佐々木正雄, 池原譲, 佐藤慎哉, 澤木弘道, 平野和己, VAN KUPPEVELT Toin H, 谷田部恭, 中西速夫, 西原祥子, 成松久. 硫酸化糖鎖の発現亢進によるホルモン不応答性前立腺癌増殖メカニズムと,その糖鎖バイオマーカーの可能性. 日本病理学会会誌. 2013. 102. 1. 215
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Hirano, Kazumi, Kuppevelt, Toin, Nishihara, Shoko. Fas signaling via 3-O-sulfated heparan sulfate is involved in a novel mechanism of the differentiation of mouse ES cells. Glycobiology. 2013. 23. 11. 1380-1380
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Nishihara, Shoko, Sasaki, Norihiko, Hirano, Kazumi. The Cell Surface Glycan LacdiNAc (GalNAc beta 1-4GlcNAc) Contributes to Self-Renewal of Mouse Embryonic Stem Cells by Regulating LIF/STAT3 Signaling. Glycobiology. 2011. 21. 11. 1464-1465
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Lectures and oral presentations (4)：
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マウスES細胞の分化にはヘパラン硫酸3-O-硫酸化構造を介したFasシグナルが必要である
(第12回日本再生医療学会総会 2013)
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マウスES細胞の分化にヘパラン硫酸3-O-硫酸化構造が必要である
(第85回日本生化学会大会 2012)
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LIF/STAT3 signaling through LacdiNAc (GalNAcβ1-4GlcNAc) glycan structures distinguishes between naïve and primed state pluripotent stem cells
(The 34th Annual Meeting of the Molecular Biology Society of Japan 2011)
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LIF/STAT3 signaling is regulated by LacdiNAc (GalNAcβ1-4GlcNAc) glycan structures on mouse embryonic stem cells
(2011)
Education (3)：
- 2009 - 現在 Soka University
- 2007 - 2009 Soka University
- 2004 - 2007 Soka University
Professional career (1)：
Work history (6)：
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