Rchr
J-GLOBAL ID：201201096283520294   Update date: Dec. 05, 2024

Komine Okiru

コミネ オキル | Komine Okiru
Affiliation and department：
Nagoya University Research Institute of Environmental Medicine Division of Stress Recognition and Response

About Nagoya University Research Institute of Environmental Medicine Division of Stress Recognition and Response


Job title： Lecturer
Research field  (1)： Neuropathology
Research keywords  (6)： 包括脳ネットワーク ,  Astrocyte ,  Alzheimer's disease ,  Immune cell ,  Microglia ,  Amyotrophic lateral sclerosis
Research theme for competitive and other funds  (12)：
  • 2024 - 2028 アルツハイマー病における免疫系による恒常性及び疾患関連ミクログリア制御機構の解明
  • 2024 - 2027 Development of a data-driven mathematical model that elucidates and regenerates the linkage between of abnormal protein accumulation and a glial cell network
  • 2021 - 2024 アルツハイマー病の神経炎症における免疫系応答の役割解明
  • 2019 - 2021 末梢免疫反応性変容モデルマウスを用いた神経変性疾患の治療標的の同定
  • 2018 - 2020 神経変性における神経・免疫のクロストークに関わる免疫細胞及び関連分子の同定
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Papers (35)：
  • Akira Sobue, Okiru Komine, Fumito Endo, Chihiro Kakimi, Yuka Miyoshi, Noe Kawade, Seiji Watanabe, Yuko Saito, Shigeo Murayama, Takaomi C Saido, et al. Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation. Cell death & disease. 2024. 15. 11. 858-858
  • Haruki Fujisawa, Takashi Watanabe, Okiru Komine, Sachiho Fuse, Momoka Masaki, Naoko Iwata, Naoya Murao, Yusuke Seino, Hideyuki Takeuchi, Koji Yamanaka, et al. Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia. Free radical biology & medicine. 2024. 223. 458-472
  • Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C Saido, Takashi Saito, Koji Yamanaka. Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease. Journal of neuroinflammation. 2024. 21. 1. 55-55
  • Okiru Komine, Syuhei Ohnuma, Kunihiko Hinohara, Yuichiro Hara, Mayuko Shimada, Tomohiro Akashi, Seiji Watanabe, Akira Sobue, Noe Kawade, Tomoo Ogi, et al. Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. iScience. 2024. 27. 2. 108872-108872
  • Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, et al. Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 47. e2315347120
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MISC (14)：
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Lectures and oral presentations  (11)：
  • アルツハイマー病モデルマウスの疾患関連ミクログリア誘導における末梢免疫環境の機能解明
    (Neuro2024 2024)
  • アルツハイマー病モデルマウスにおける末梢免疫環境がミクログリアに与える影響の解明
    (第46回日本神経科学大会 2023)
  • 筋萎縮性側索硬化症モデルにおける免疫環境とミクログリア機能連関の解明
    (第128回日本解剖学会総会・全国学術集会 2023)
  • 筋萎縮性側索硬化症モデルマウスにおけるミクログリアの不均一性と機能変化
    (第45回日本神経科学大会(Neuro2022) 2022)
  • Elucidating the association between the peripheral immune environment and the neuroinflammation in amyotrophic lateral sclerosis mice
    (The 25th Annual Meeting of the Japan Glia 2021)
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Education (3)：
  • 2003 - 2007 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
  • 2001 - 2003 Tokyo University of Science
  • 1997 - 2001 Tokyo University of Science Faculty of Science and Technology Applied Biological Science
Professional career (1)：
  • 医学博士 (東京医科歯科大学)
Work history (5)：
  • 2023/04 - 現在 Nagoya University Research Institute of Environmental Medicine Lecturer
  • 2013/08 - 2023/03 Nagoya University Research Institute of Environmental Medicine Assistant professor
  • 2012/01 - 2013/07 RIKEN Brain Research Institute Laboratory for Motor Neuron Disease Resercher
  • 2008/04 - 2010/12 Tokyo Medical and Dental University Medical Research Institute Assistant professor
  • 2007/04 - 2008/03 Tokyo Medical and Dental University Resercher
Awards (4)：
  • 2019/10 - 名古屋大学 環境医学研究所 若手優秀論文賞
  • 2006/03 - 東京医科歯科大学21世紀COE若手研究者シンポジウム研究発表会 優秀研究員賞
  • 2004/03 - 東京医科歯科大学21世紀COE若手研究者シンポジウム研究発表会 優秀研究員賞
  • 2003/03 - 財団法人科学技術振興会小玉記念科学賞
Association Membership(s) (3)：
Society for neuroscience ,  THE JAPAN NEUROSCIENCE SOCIETY ,  日本神経免疫学会
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