Mamoru Fukuchi

フクチマモル | Mamoru Fukuchi

Affiliation and department：
Homepage URL (1)： https://m.facebook.com/UHWMolNeurosci/

Research field (6)： Nutrition and health science , Applied biochemistry , Internal medicine - General , Molecular biology , Neuroscience - general , Pharmaceuticals - health and biochemistry

Research keywords (19)：包括脳ネットワーク , Imaging , Luciferase , c-fos , Calcineurin , NMDA receptor , CRTC , SRF , Post-transcriptional regulation , Transcriptional regulation , Calcium signal , Gene expression , Neuronal activity , Arc , GPCR , BDNF , PACAP , Synapse , CREB

Research theme for competitive and other funds (15)：

2022 - 2026 Development of therapeutic and preventive agents for Alzheimer's disease based on BDNF expression in the brain
2019 - 2022 Involvement of BDNF in the pathogenesis of obesity; BDNF signaling hypothesis in adipose tissue
2016 - 2019 伝統医薬品をターゲットとした安全性および有効性に優れた抗認知症薬開発の新規戦略
2016 - 2017 末梢性BDNF遺伝子発現を利用した神経伝達物質受容体活性評価およびうつ病治療戦略
2015 - 2017 BDNF遺伝子発現誘導能を指標とした脳機能改善薬候補薬の探索

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Papers (59)：

Shunsuke Shimizu, Aoi Nakano, Daisuke Ihara, Hironori Nakayama, Michiko Jo, Kazufumi Toume, Katsuko Komatsu, Naotoshi Shibahara, Masaaki Tsuda, Mamoru Fukuchi, et al. Panax notoginseng root extract induces nuclear translocation of CRTC1 and Bdnf mRNA expression in cortical neurons. Drug discoveries & therapeutics. 2024
Mamoru Fukuchi, Yumi Shibasaki, Yuto Akazawa, Hitoshi Suzuki-Masuyama, Ken-Ichi Takeuchi, Yumika Iwazaki, Akiko Tabuchi, Masaaki Tsuda. Neuron-selective and activity-dependent splicing of BDNF exon I-IX pre-mRNA. Neurochemistry international. 2024. 105889-105889
Kurumi Sakata, Mamoru Fukuchi. Accelerated BDNF expression in visceral white adipose tissues following high-fat diet feeding in mice. Genes to Cells. 2024
Ryo Ikegami, Takahiro Inoue, Yasuyuki Takamatsu, Taichi Nishio, Mamoru Fukuchi, Sanae Haga, Michitaka Ozaki, Hiroshi Maejima. In vivo bioluminescence imaging revealed the change of the time window of BDNF expression in the brain elicited by a single bout of exercise following repeated exercise. Neuroscience Letters. 2024. 137830-137830
Yuka Matsuoka, Hibiki Nakasone, Rento Kasahara, Mamoru Fukuchi. Expression Profiles of Brain-Derived Neurotrophic Factor Splice Variants in the Hippocampus of Alzheimer's Disease Model Mouse. Biological & pharmaceutical bulletin. 2024. 47. 11. 1858-1867

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MISC (32)：

福地守, 渡辺和樹, 三反崎聖, 福田桃子, 松本聡. Aminothioneine, a product derived from golden oyster mushrooms, induces BDNF gene expression in cultured cortical neurons. 日本薬学会年会要旨集(Web). 2022. 142nd
福地守, 齊藤亮平, 齊藤亮平, 牧昌次郎, 萩原なみ, 中島夢奈, 和泉宏謙, 三反崎聖, 森寿. Visualizing induction of BDNF gene expression in living mouse brain using AkaLumine hydrochloride “TokeOni“, a novel substrate for luciferase. 日本薬学会年会要旨集(Web). 2021. 141st
Fukuchi Mamoru. 自由行動下の動物の深部組織から非侵襲的に発光を検出する技術. ファルマシア. 2019. 55. 1. 69
福地守, 福地守, 和泉宏謙, 森寿, 木山正啓, 大塚智史, 牧昌次郎, 田渕明子, 津田正明. 生物発光を利用したBDNF遺伝子発現変化の計測. 日本生化学会大会(Web). 2017. 2017年度. [2P-1200]
川畑伊知郎, 来延新, 大宅史織, 森田淳一, 加藤茂樹, 田渕明子, 福地守, 津田正明, 大橋一正, 水野健作, et al. In vitroとin vivoにおける、Rho/MAL/SRF経路を介したV-1遺伝子による黒質線条体のドーパミン系の機能の調節(In vitro and in vivo regulation of the nigrostriatal dopaminergic function by V-1 gene via the Rho/MAL/SRF pathway). パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2015. 9回. 66-66

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Books (1)：

転写因子による生命現象解明の最前線クロマチン制御機構・エピジェネティクスと転写因子複合体ネットワークの包括的解明
羊土社 2007

Lectures and oral presentations (75)：

高輝度かつ近赤外発光が得られる新規ルシフェラーゼ基質AkaSukeを用いたBDNF発現の可視化
(日本薬学会第144年会 2024)
Expression profiles of BDNF mRNA splice variants in the hippocampus of Alzheimer’s model mouse
(2023)
Analysis of regulatory mechanism for splicing of BDNF RNA in neurons
(2023)
高脂肪食給後のマウス白色脂肪組織におけるBDNF発現誘導;内臓脂肪および皮下脂肪においてBDNFが異なる役割を果たす可能性
(日本薬学会第143年会 2023)
Comparison of d-luciferin and its analogs for in vivo bioluminescence imaging using Bdnf-Luciferase transgenic mouse
(NEURO2022 2022)

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Education (2)：

2001 - 2006 Toyama Medical & Pharmaceutical University Graduate School of Pharmaceutical Sciences
1997 - 2001 Toyama Medical & Pharmaceutical University Faculty of Pharmaceutical Sciences

Professional career (1)：

富山医科薬科大学大学院薬学研究科 (博士(薬学))

Work history (4)：

2020/04 - 現在 Takasaki University of Health and Welfare Faculty of Pharmacy Professor
2017/04 - 2020/03 Takasaki University of Health and Welfare Faculty of Pharmacy
2007/04 - 2017/03 University of Toyama, Graduate School of Medicine & Pharmaceutical Sciences Assistant professor
2006/04 - 2007/04 University of Toyama, Graduate School of Medicine % Pharmaceutical Sciences Research Associate

Awards (3)：

2016/11 - 日本薬学会北陸支部日本薬学会北陸支部学術奨励賞
2015/05 - 日本生化学会北陸支部日本生化学会第19回支部奨励賞
2005/07 - 日本薬学会北陸支部大学院優秀発表賞

Association Membership(s) (7)：

日本認知症予防学会 , 日本薬学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPAN NEUROSCIENCE SOCIETY , Society for Neuroscience

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