Tsuiji Hitomi

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://sites.google.com/view/agusougou?usp=sharing

Research field (3)： Neuroscience - general , Molecular biology , Other

Research keywords (6)：薬学教育 , 筋萎縮性側索硬化症 , 認知症 , スプライシング , ノンコーディングRNA , RNA疾患

Research theme for competitive and other funds (5)：

2020 - 2024 RNA結合タンパク質量の増減による、筋萎縮性側索硬化症ALSの治療法開発
2017 - 2020 Elucidation of pathophysiological implications of interneuron degeneration in frontotemporal dementia
2013 - 2017 Common defects of RNA metabolism in motor neuron diseases SMA and ALS
2011 - 2012 Defective RNA metabolism in motor neurons from Amyotrophic Lateral Scelosis patients
2007 - 2008 Functional analysis of Gomafu, the mRNA-like non-coding RNA

Papers (23)：

Antonios Apostolopoulos, Naohiro Kawamoto, Siu Yu A Chow, Hitomi Tsuiji, Yoshiho Ikeuchi, Yuichi Shichino, Shintaro Iwasaki. dCas13-mediated translational repression for accurate gene silencing in mammalian cells. Nature communications. 2024. 15. 1. 2205-2205
Shintaro Oya, Katsunari Korogi, Takao Kohno, Hitomi Tsuiji, Dmytro I Danylchuk, Andrey S Klymchenko, Yosuke Niko, Mitsuharu Hattori. The Plasma Membrane Polarity Is Higher in the Neuronal Growth Cone than in the Cell Body of Hippocampal and Cerebellar Granule Neurons. Biological & pharmaceutical bulletin. 2023. 46. 12. 1820-1825
Yuma Kato, Minnie Naganuma, Ikuma Nakagawa, Kazunari Onodera, Hideyuki Okano, Haruhisa Inoue, Mitsuharu Hattori, Yohei Okada, Hitomi Tsuiji. C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein. bioRxiv. 2021
Hiroto Inagaki, Nao Hosoda, Hitomi Tsuiji, Shin-ichi Hoshino. Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation. Journal of Biological Chemistry. 2020. 295. 47. 15810-15825
Eisuke Okugawa, Himari Ogino, Tomofumi Shigenobu, Yuko Yamakage, Hitomi Tsuiji, Hisashi Oishi, Takao Kohno, Mitsuharu Hattori. Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice. Scientific reports. 2020. 10. 1. 4471-4471

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MISC (8)：

Hitomi Tsuiji, Koji Yamanaka. Animal Models for Neurodegenerative Disorders. Animal Biotechnology: Models in Discovery and Translation. 2013. 39-56
山中宏二, 築地仁美, 渡辺祥司, 金子貢巳, 古屋亜佐子, 井口洋平, 熱田直樹, 田中章景, 祖父江元, 初田裕幸, et al. 病態に根ざしたALSの新規治療法開発 TDP-43の機能変調による運動神経変性機序の解明. 神経変性疾患に関する調査研究班分科班「病態に根ざしたALSの新規治療法開発」平成24年度研究報告書. 2013
Hitomi Tsuiji, Ayane Kataoka, Koji Yamanaka. Regulation of spliceosome by ALS-causative gene TDP-43. NEUROSCIENCE RESEARCH. 2011. 71. E102-E102
曽根正光, 築地仁美, 芳本玲, 吉田稔, 北市清幸, 山本経之, 阿部高也, 高雄啓三, 宮川剛, 中川真一. 核内長鎖ノンコーディングRNA Gomafuは動物の行動を制御する. 日本RNA学会年会要旨集. 2010. 12th. 70
築地仁美, 曽根正光, 中川真一. mRNA型ノンコーディングRNAであるGomafuの生化学的性質の検討. 日本RNA学会年会要旨集. 2007. 9th. 234

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Education (3)：

Professional career (1)：

Work history (9)：

2022/09 - 現在 Aichi Gakuin University Graduate School of Pharmacy, Studies of Pharmacy
2022/04 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences Visiting Professor
2022/04 - 現在 Aichi Gakuin University School of Pharmacy, Department of Pharmaceutical Health Care and Science Professor
2014/04 - 2022/03 Nagoya City University Graduate School of Pharmaceutical Sciences
2014 - 2015 Nagoya University

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Committee career (3)：

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