Research field (3):
Pathobiochemistry
, Cell biology
, Molecular biology
Research keywords (2):
Cancer
, Drug Resistance
Research theme for competitive and other funds (9):
2022 - 2025 膵臓癌の生存や抗がん剤耐性を亢進させる新たな分子機構の解明
2020 - 2022 がん治療における薬剤耐性阻害を目指したZIC5標的HDOの開発
2017 - 2021 がんにおける薬剤耐性の阻害を目指したZIC5標的薬の同定と検証
2016 - 2017 脂質代謝酵素の発現異常による大腸癌悪性化メカニズムの解明
2014 - 2016 神経冠形成遺伝子によるがん悪性化促進機構の解明
2015 - 2016 神経冠遺伝子が促進するがん薬剤耐性機構の解明と応用
2014 - 2015 神経冠形成遺伝子に着目した前立腺がん薬剤耐性機構の破壊
2010 - 2010 がん分子標的の探索、機能解析とがん分子標的治療薬の開発
2003 - 2005 アフリカツメガエルにおける新規の神経形成遺伝子の機能解析
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Papers (31):
Reiko Satow, Yudai Suzuki, Shinobu Asada, Sae Ota, Masashi Idogawa, Shiori Kubota, Noi Ikeo, Atsuko Yoneda, Kiyoko Fukami. Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells. iScience. 2022. 25. 12. 105501-105501
Reiko Satow, Takeru Watanabe, Moeka Nomura, Shota Inagaki, Atsuko Yoneda, Kiyoko Fukami. Patulin and LL-Z1640 -2 induce apoptosis of cancer cells by decreasing endogenous protein levels of Zic family member 5. Journal of Cellular and Molecular Medicine. 2022
Reiko Satow, Yuna Aiga, Takeru Watanabe, Nako Ishizuka, Atsuko Yoneda, Kiyoko Fukami. Zic family member 5 promotes survival in human pancreatic cancer and cholangiocarcinoma cells. Biochemistry and Biophysics Reports. 2022. 31. 101289-101289
Kazuya Tsujita, Reiko Satow, Shinobu Asada, Yoshikazu Nakamura, Luis Arnes, Keisuke Sako, Yasuyuki Fujita, Kiyoko Fukami, Toshiki Itoh. Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. Nature communications. 2021. 12. 1. 5930-5930
Atsuko Yoneda, Kaori Kanemaru, Ai Matsubara, Erika Takai, Makoto Shimozawa, Reiko Satow, Hideki Yamaguchi, Yoshikazu Nakamura, Kiyoko Fukami. Phosphatidylinositol 4,5-bisphosphate is localized in the plasma membrane outer leaflet and regulates cell adhesion and motility. Biochemical and Biophysical Research Communications. 2020. 527. 4. 1050-1056
T. Yamada, R. Satow, M. Masuda, K. Honda. INTEGRATED GENOMIC APPROACHES TO THERAPEUTIC TARGET IDENTIFICATION FOR HEPATOCELLULAR CARCINOMA. ANNALS OF ONCOLOGY. 2012. 23. 536-536
下重 美紀, 佐藤 礼子, 地神 貴史, 山田 哲司. WntシグナルによるTNIKの活性化(Activation of Traf2- and Nck-interacting kinase by Wnt Signaling). 日本癌学会総会記事. 2010. 69回. 307-307
Miki Shitashige, Reiko Satow, Tesshi Yamada. TNIK is a protein kinase essential for Wnt signaling and colorectal carcinogenesis. CANCER RESEARCH. 2010. 70
小林 英介, 佐藤 礼子, 中山 ロバート, 下重 美紀, 地神 貴史, 尾野 雅哉, 本田 一文, 森岡 秀夫, 川井 章, 市川 仁, et al. 骨肉腫肺転移新規予測マーカーアルギニノコハク酸合成酵素の同定と新しい治療戦略(Argininosuccinate synthetase, novel predictive biomarker for development of pulmonary metastasis in osteosarcoma). 日本癌学会総会記事. 2009. 68回. 347-347
下重 美紀, 佐藤 礼子, 地神 貴史, 廣橋 説雄, 山田 哲司. Wntシグナルと大腸癌増殖に必須の蛋白質キナーゼの同定(Identification of a protein kinase essential for Wnt signaling and colorectal cancer growth). 日本癌学会総会記事. 2009. 68回. 143-143