Shirakawa Jun

シラカワジュン | Shirakawa Jun

Affiliation and department：
Homepage URL (1)： https://diabetes.imcr.gunma-u.ac.jp/

Research field (5)： Metabolism and endocrinology , Nutrition and health science , Pathobiochemistry , Laboratory animal science , Cell biology

Research keywords (6)： pancreatic beta cell , diabetes , obesity , human islets , endocrinology , database analysis

Research theme for competitive and other funds (7)：

2020 - 2023 Regulation of beta cell fate during dedifferentiation
2020 - 2023 Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity
2018 - 2021 A novel sarcopenia model by insulin / IGF-1 receptor inhibition
2018 - 2020 Heterogeneity of pancreatic islets
2016 - 2019 Fate determination of pancreatic beta cells by glucokinase activation

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Papers (91)：

Junko Nishida, Takahiro Tsuno, Shigeharu G Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi. Encapsulated human islets in alginate fiber maintain long-term functionality. Endocrine journal. 2024. 71. 3. 253-264
Sakiko Terui, Mari Igari, Takahiro Tsuno, Tomoko Okuyama, Ryota Inoue, Mayu Kyohara, Yasuo Terauchi, Jun Shirakawa. Immediate Impact of Switching from Dipeptidyl Peptidase 4 (DPP4) Inhibitors to Low-Dose (0.3 mg) Liraglutide on Glucose Profiles: A Retrospective Observational Study. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2024
Sohyun Moon, Lamyaa Alsarkhi, Tai-Tu Lin, Ryota Inoue, Azeddine Tahiri, Cecilia Colson, Weikang Cai, Jun Shirakawa, Wei-Jun Qian, Jerry Yingtao Zhao, et al. Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 10. e23185
Kuniyuki Nishiyama, Masato Ono, Takahiro Tsuno, Ryota Inoue, Ayako Fukunaka, Tomoko Okuyama, Mayu Kyohara, Yu Togashi, Setsuko Fukushima, Takuto Atsumi, et al. Protective effects of imeglimin and metformin combination therapy on β-cells in db/db male mice. Endocrinology. 2023. 164. 8
Jun Shirakawa. Signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes. Journal of diabetes investigation. 2023. 14. 6. 735-740

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MISC (33)：

Jun Shirakawa, Erin R. Okawa, Rohit N. Kulkarni. Characterization of Insulin-Like Growth Factor-2 Receptor (IGF-2R) in Pancreatic beta-Cells. DIABETES. 2017. 66. A12-A12
Mayu Kyohara, Jun Shirakawa, Ayuko Kimura, Hisashi Hirano, Yasuo Terauchi. Identification of Soluble EGFR as a Serum Biomarker of Insulin Resistance by a Quantitative Proteomic Analysis Using Mice with Diabetes. DIABETES. 2017. 66. A542-A542
Manoj K. Gupta, Heidrun Vethe, Vilas Wagh, Jun Shirakawa, Samir Softic, Harald Barsnes, Marc Vaudel, Tomozumi Takatani, Rachel Martinez, Jiang Hu, et al. Differential Regulation of Metabolic and Protein Synthesis Pathways in Mouse Embryonic Fibroblasts and Induced Pluripotent Stem Cells from Leptin Receptor Deficient Mice. DIABETES. 2016. 65. A504-A505
Jun Shirakawa, Megan Fernandez, Rohit N. Kulkarni. Histone H3 Variant Centromere Protein A (CENP-A) Is Critical for beta-Cell Proliferation. DIABETES. 2016. 65. A17-A17
Ivan A. Valdez, Ercument Dirice, Manoj K. Gupta, Jun Shirakawa, Adrian K. K. Teo, Rohit N. Kulkarni. Inflammatory Cytokines Activate NGN3 and Induce Pancreatic Ductal-to-Endocrine Cell Differentiation. DIABETES. 2016. 65. A531-A531

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Education (2)：

- 2011 Yokohama City University Graduate School of Medicine
- 2006 Tsukuba University School of Medicine

Professional career (2)：

M.D.
Ph.D. (University of Tsukuba)

Work history (8)：

2020 - 現在 Gunma University Institute for Molecular and Cellular Regulation, Laboratory of Diabetes and Metabolic Disorders Professor
2019 - 2020 Yokohama City University
2017 - 2019 Yokohama City University
2014 - 2017 Harvard Medical School Joslin Diabetes Center Research Fellow
2013 - 2014 Yokohama City University School of Medicine, Department of Endocrinology and Metabolism Assistant Professor

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Awards (17)：

2022/10 - Asian Association for Study of Diabetes (AASD) The Masato Kasuga Award for Outstanding Scientific Achievement
2021/05 - JDS Lilly award
2020/05 - 横浜市立大学医学会賞
2019/06 - 横浜市立大学医学部医学科平成30年度ベストティーチャー賞個人賞
2019/05 - 日本内分泌学会研究奨励賞

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Association Membership(s) (6)：

JAPANESE SOCIETY OF EXPERIMENTAL DIABETES AND OBESITY (JSEDO) , THE JANPANESE SOCIETY OF INTERNAL MEDICINE , THE JAPAN ENDOCRINE SOCIETY , JAPAN DIABETES SOCIETY , アジア糖尿病学会(AASD) , 日本生化学会

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