Rchr
J-GLOBAL ID:201301003727755748
Update date: Sep. 29, 2024
Kurachi Makoto
クラチ マコト | Kurachi Makoto
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://kaken.nii.ac.jp/d/r/00396722.ja.html
Research field (4):
Pathobiochemistry
, Medical biochemistry
, Immunology
, Gastroenterology
Research keywords (21):
IRF4
, BATF
, Pioneering transcription factor
, CTL exhaustion
, 免疫記憶
, 老化
, ワクチン
, CXCR3
, 二次リンパ組織
, 抗原特異的CD8陽性T細胞
, ウイルス免疫
, メモリー細胞
, CD8陽性T細胞
, CTL
, ケモカイン
, 免疫応答の場
, 抑制性T細胞
, 感染症
, 免疫細胞治療
, B型肝炎ウイルス
, 免疫学
Research theme for competitive and other funds (16):
- 2022 - 2025 T細胞疲弊における転写因子制御とクロマチンランドスケープ連関の解明と応用
- 2019 - 2022 パイオニア転写因子BATF-IRF4複合体が制御するCTL分化機序の解明
- 2011 - 2013 慢性感染症におけるCD8T細胞応答の解析
- 2010 - 2012 ケモカイン受容体CXCR3によるメモリーCTL樹立・維持の制御機構の解明
- 2010 - 2012 Elucidation of the molecular bases of the generation and maintenance of CTL memory by next generation DNA sequencer
- 2010 - 2011 Role of chemokine receptor CXCR3 on generation and maintenance of memory CD8 T cells
- 2009 - 2011 Novel radiation therapy with regulation of immune response
- 2007 - 2011 Cellular dynamics in autoimmune responses
- 2008 - 2010 反復感染応答におけるメモリーCD8陽性T細胞集団の老化と維持機構に関する研究
- 2008 - 2010 The analysis of inflammatory cascade between antigen specific CTLs and liver injury using hepatitis model
- 2008 - 2009 Senescence and maintenance mechanism of antigen-specific CD8+ T cells upon repeatitive antigenic challenges.
- 2007 - 2008 Novel combined modality therapy with radiotherapy and immunotherapy for the treatment of cancer
- 2007 - 2008 Clinical research of a new immunotherapy for the lung cancer : Autologous gamma-delta T-cell adoptive immunotherapy
- 2006 - 2008 Analysis of generation and control mechanism of CD8+ T cells by chemokines
- 2005 - 2006 Immunoregulatory mechanisms for the hepatitis virus specific T cell response
- 2005 - 2006 Clinical research on a new immunotherapy for the treatment of non-small cell lung cancer
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Papers (49):
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Ryu Imamura, Hiroki Sato, Dominic Chih-Cheng Voon, Takayoshi Shirasaki, Masao Honda, Makoto Kurachi, Katsuya Sakai, Kunio Matsumoto. Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 40. e2307318120
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Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata, et al. Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET. Nature communications. 2022. 13. 1. 3176-3176
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Hsiao-Wei Tsao, James Kaminski, Makoto Kurachi, R Anthony Barnitz, Michael A DiIorio, Martin W LaFleur, Wataru Ise, Tomohiro Kurosaki, E John Wherry, W Nicholas Haining, et al. Batf-mediated epigenetic control of effector CD8+ T cell differentiation. Science immunology. 2022. 7. 68. eabi4919
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Hiroyasu Aoki, Satoshi Ueha, Shigeyuki Shichino, Haru Ogiwara, Kohei Shitara, Manami Shimomura, Toshihiro Suzuki, Tetsuya Nakatsura, Makiko Yamashita, Shigehisa Kitano, et al. Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer. Cancer immunology research. 2021. 9. 6. 624-636
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Zeyu Chen, Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He, Hua Huang, Sasikanth Manne, Zhendong Cao, Amy E Baxter, et al. In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer. Cell. 2021. 184. 5. 1262-1280
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MISC (26):
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Zeyu Chen, Erietta Stelekati, Makoto Kurachi, Sixiang Yu, Sasikanth Manne, E. John Wherry. MiR-150 negatively regulates CD8+T cell memory formation. JOURNAL OF IMMUNOLOGY. 2016. 196
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Bertram R. Bengsch, Andy L. Johnson, Makoto Kurachi, Pamela Odorizzi, Kristen E. Pauken, John Attanasio, E. John Wherry. Early onset and persistence of metabolic alterations in exhausted T cells is regulated by PD-1. JOURNAL OF IMMUNOLOGY. 2016. 196
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倉知 慎, 松島 綱治. CTLメモリー誘導・維持の場の形成と介在因子. 感染・炎症・免疫. 2012. 42. 1. 68-71
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倉知 慎, 松島 綱治. ケモカイン受容体CXCR3によるメモリーCD8 T細胞分化制御. 実験医学. 2011. 29. 17. 133-142
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上羽 悟史, 庄野 雄介, 倉知 慎, 松島 綱治. CD4陽性T細胞の除去による造血ニッチの保護と移植片対腫瘍効果の保存(Depletion of allo-CD4 T cells protects heniatopoietic niche while preserves graft-versus-tumor effects after allo-HSCT). 日本癌学会総会記事. 2010. 69回. 101-101
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Books (2):
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実験医学別冊 ラボ必携 フローサイトメトリーQ&A 正しいデータを出すための100箇条
羊土社 2017 ISBN:9784758122351
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予防医学事典
朝倉書店 2005 ISBN:9784254300819
Lectures and oral presentations (3):
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特別授業「体を守る免疫の働き」
(長野県長野高校学部学科研究会 2021)
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特別講義「体をまもる免疫の働き」
(石川県立泉丘高校SSH特別講義 2020)
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特別授業「なぜ私は医学系研究者として不確実性を愛するようになったのか?」
(金沢大学附属高等学校特別授業 2019)
Professional career (1):
Work history (9):
- 2018/09 - 現在 Kanazawa University Graduate School of Medical Science Professor
- 2016/09 - 2018/08 University of Pennsylvania School of Medicine Research Associate
- 2011/09 - 2016/08 University of Pennsylvania School of Medicine Post doc fellow
- 2006/12 - 2011/08 The University of Tokyo Graduate School of Medicine
- 2004/06 - 2006/11 The University of Tokyo Graduate School of Medicine
- 2002/04 - 2004/05 科学技術振興事業団 東京大学医学部分子予防医学講座 派遣研究員
- 1999/04 - 2000/03 金沢大学附属病院 消化器内科 大学院生(研修医)
- 1998/04 - 1999/03 黒部市民病院 内科 研修医
- 1997/04 - 1998/03 金沢大学附属病院 内科 研修医
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Awards (1):
- 2019/09 - 北國がん基金 第33回北國がん基金研究活動助成
Association Membership(s) (4):
日本分子生物学会
, 日本生化学会
, 日本免疫学会
, 日本内科学会
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