Sato Shinichi

サトウシンイチ | Sato Shinichi

Affiliation and department：
Job title： Associate Professor

Research field (2)： Pharmaceuticals - chemistry and drug development , Biochemistry

Research keywords (5)： Protein Chemical Labeling , Radical Reaction , Photocatalyst , Tyrosine Modification , Antibody Chemical Modification

Research theme for competitive and other funds (13)：

2023 - 2027 Intracellular reaction control of photocatalytic proximity labeling and target identification of bioacitive molecules
2023 - 2025 Comprehensive analysis of binding proteins of symbiotic materials utilizing proximity labeling
2021 - 2024 生物活性分子のプローブ化不要な結合タンパク質網羅的同定
2019 - 2023 Target identification of bioactive molecules based on detection of protein denaturation state
2021 - 2023 Comprehensive chemical labeling and identification of low-affinity protein interactions

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Papers (76)：

Keita Nakane, Chizu Fujimura, Shogo Miyano, Zhengyi Liu, Tatsuya Niwa, Hafumi Nishi, Tetsuya Kadonosono, Hideki Taguchi, Shusuke Tomoshige, Minoru Ishikawa, et al. Laccase-catalyzed tyrosine click reaction with 1-methyl-4-arylurazole: rapid labeling on protein surfaces. Chemical communications (Cambridge, England). 2024
Shinichi Sato, Shogo Miyano, Keita Nakane, Zhengyi Liu, Munehiro Kumashiro, Tomohide Saio, Yuya Tanaka, Akira Shigenaga, Chizu Fujimura, Eri Koyanagi, et al. Tyrosine Bioconjugation Using Stably Preparable Urazole Radicals. Tetrahedron Chem. 2024. 100111-100111
Ahmed Mostafa Abdelhady, Shinichi Sato, Tatsuki Masuzawa, Keishi Deguchi, Keita Nakane, Zhengyi Liu, Kazuki Kuwahara, Fumi Nagatsugi, Takanori Oyoshi, Kazumitsu Onizuka. Photocatalytic proximity labeling for the identification of G-quadruplex DNA-interacting proteins. 2024
Shusuke Tomoshige, Fumiko Komatsu, Tomoko Kikuchi, Miku Sugiyama, Yushi Kawasaki, Kenji Ohgane, Yuuki Furuyama, Shinichi Sato, Minoru Ishikawa, Kouji Kuramochi. A small-molecule degron with a phenylpropionic acid scaffold. Bioorganic & Medicinal Chemistry. 2024. 117789-117789
Aoi Kunitomi, Shuhei Chiba, Nahoko Higashitani, Atsushi Higashitani, Shinichi Sato, Kensaku Mizuno, Kazumasa Ohashi. Solo regulates the localization and activity of PDZ-RhoGEF for actin cytoskeletal remodeling in response to substrate stiffness. Molecular Biology of the Cell. 2024

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MISC (10)：

Wakana Yamada, Shusuke Tomoshige, Sho Nakamura, Shinichi Sato, Minoru Ishikawa. Targeted Protein Degradation in the Mitochondrial Matrix and Its Application to Chemical Control of Mitochondrial Morphology. ChemRxiv. 2024
佐藤伸一. 抗体の部位選択的化学修飾による機能性付与. ファルマシア. 2023. 59. 10. 893-897
佐藤伸一, 中根啓太. チロシン/ヒスチジン残基化学修飾法の開発と触媒的反応制御. MEDCHEM NEWS. 2023. 33. 2. 79-83
佐藤伸一. チロシン残基修飾法の開発と抗体の部位選択的修飾. 「生化学」誌. 2023. 95. 1. 60-65
Site Selective Antibody Functionalization Using Solvent-Accessibility-Dependent Tyrosine Modification. 2022. 15. 1. 3-6

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Books (4)：

Lectures and oral presentations (263)：

近赤外光駆動型近接ヒスチジン残基修飾反応の開発
(日本薬学会第144年会 2024)
網羅的チロシン残基修飾による核酸結合タンパク質同定
(日本薬学会第144年会 2024)
ユビキチンリガーゼ CHIPを用いたタンパク質分解キメラ化合物の創製
(日本薬学会第144年会 2024)
生物活性分子の標的同定を指向したタンパク質熱変性の可視化プローブ開発
(日本農芸化学会2024年度大会 2024)
細胞壁多糖α-1,3-グルカン依存的凝集性の評価系構築に向けたα-1,3-グルカノオリゴ糖被覆ビーズの作製
(日本農芸化学会2024年度大会 2024)

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Education (3)：

2008 - 2011 東京大学大学院薬学系研究科分子薬学専攻博士後期課程
2006 - 2008 東京大学大学院薬学系研究科分子薬学専攻修士課程
2002 - 2006 Meiji Pharmaceutical University Faculty of Pharmacy Department of Medicinal Chemistry

Professional career (1)：

Work history (7)：

2024/04 - 現在 Tohoku University Frontier Research Institute for Interdisciplinary Sciences Associate Professor
2020/04 - 2024/03 Tohoku University Frontier Research Institute for Interdisciplinary Sciences Assistant Professor
2016/04 - 2020/03 Tokyo Institute of Technology Laboratory for Chemistry and Life Science, Institute of Innovative Research Assitant Professor
2014/02 - 2016/03 Tokyo Institute of Technology Chemical Resources Laboratory Assistant Professor
2012/04 - 2014/01 Gakushuin University Faculty of Science, Department of Chemistry Assistant Professor

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Committee career (3)：

Awards (11)：

2023/04 - 文部科学省令和5年度科学技術分野の文部科学大臣表彰若手科学者賞相互作用解明を実現する触媒的タンパク質化学修飾研究
2020/11 - The Phamaceutical Society of Japan Award for Young Scientists Development of Tyrosine Chemical Modifications and Elucidation of Biological Function
2018/09 - (公社)日本薬学会日本薬学会関東支部奨励賞触媒的タンパク質チロシン残基の化学修飾法の開発と応用
2018/09 - 東京工業大学東京工業大学挑戦的研究賞
2018/06 - 日本ケミカルバイオロジー学会日本ケミカルバイオロジー学会第13回年会ポスター賞溶媒接触度依存的なチロシン残基修飾による抗体の部位選択的機能化

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