Sasaki Atsuo

Sasaki Atsuo | Sasaki Atsuo

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.thesasakilab.org/index_j.php

Research field (1)： Molecular biology

Research keywords (5)： GTP metabolism , GTP energy sensor , Cancer energy metabolism , phosphoinositide , lipid signaling

Research theme for competitive and other funds (1)：

2020 - 2024 Exploring the molecular mechanism of GTP-driven stress response system

Papers (92)：

Satoshi Kofuji, Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Yoshihisa Hirota, Aki Ogawa-Iio, Hirotaka Kanoh, Mika Sasaki, Kaori Kofuji, et al. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochemical and biophysical research communications. 2024. 718. 149981-149981
Kari Kopra, Randa Mahran, Titta Yli-Hollo, Sho Tabata, Emmiliisa Vuorinen, Yuki Fujii, Iida Vuorinen, Aki Ogawa-Iio, Akiyoshi Hirayama, Tomoyoshi Soga, et al. Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay. Analytical and bioanalytical chemistry. 2023
Yoshiki Ikeda, Mindy I Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Mika Sasaki, Yoshihisa Hirota, Rajan Pragani, Min Shen, Matthew B Boxer, et al. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023. 679. 116-121
Koh Takeuchi, Miki Senda, Yoshiki Ikeda, Koji Okuwaki, Kaori Fukuzawa, So Nakagawa, Mika Sasaki, Atsuo T Sasaki, Toshiya Senda. Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ. The FEBS journal. 2023
Natsuski Osaka, Atsuo T Sasaki. Beyond Warburg: LDHA activates RAC for tumour growth. Nature metabolism. 2022. 4. 12. 1623-1625

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MISC (27)：

廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, 竹内恒, 千田俊哉, 佐々木敦朗, et al. Metabolic regulation by the GTP sensor PI5P4Kβ: towards the treatment of diabetes, cancer cachexia and sarcopenia. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, TILVE Diego, 竹内恒, 千田俊哉, et al. Metabolic dysregulation by disruption of GTP resilience: a new pathological mechanism for metabolic diseases. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
鈴木章平, 廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, PEREZ-TILVE Diego, 佐々木敦朗. GTP非依存性PI5P4Kβ点変異マウスの作出とその表現型解析. 日本薬学会関東支部大会講演要旨集. 2021. 65th (CD-ROM)
竹内恒, 池田幸樹, 千田美紀, 原田彩佳, 奥脇弘次, 福澤薫, 中川草, 長瀬里沙, 今井美咲, 廣田佳久, et al. Molecular evolution of PI5P4Kβ that underlies the GTP resilience. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
降旗大岳, 降旗大岳, 原田彩佳, 中川草, 竹内恒, 佐々木敦朗, 千田俊哉, 千田俊哉, 加藤龍一, 加藤龍一. Crystal structural analysis of Branchiostoma floridae PI5P4K for investigation of evolution of GTP sensor. 量子ビームサイエンスフェスタ(Web). 2019. 2018

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Lectures and oral presentations (32)：

Role of GTP metabolism in Ovarian Cancer
(UC-CCHMC reproductive medicine group meeting 2013)
Introduction of UC-Tomorrow, Japanese Research Community in Cincinnati
(JSPS Washington DC- United Japanese Researcher Abroadh 2013)
A proposal of strategy for UC-BTC in next 10 years
(University of Cincinnati, Brain Tumor Center 2013)
Impact of GTP metabolism on Liver Functions
(シンシナティー小児病院・消化器センターセミナー 2013)
Serine metabolism and GTP biosynthesis
(UC Signaling Group 2013)

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Education (3)：

1995 - 1997 University of Hiroshima
1991 - 1995 Science University of Tokyo
Kurume University School of Medicine

Professional career (1)：

Work history (11)：

2018/10 - 現在 Keio University Project Professor
2016/09 - 現在 University of Cincinnati College of Medicine Associate Professor
2012/07 - 2016/08 University of Cincinnati College of Medicine Assistant Professor
2010/04 - 2012/06 Harvard Medical School Systems Biology Instructor
2001/04 - 2002/11 Kyushu University Medicine JSPS Research Fellow

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Committee career (1)：

2013/01 - 現在シンシナティー大・脳腫瘍センター応用研究グループ総括

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