Rchr
J-GLOBAL ID：201301022415286028
Update date: Apr. 05, 2024
Watanabe Seiji
ワタナベ セイジ | Watanabe Seiji
Affiliation and department：
Job title：
Lecturer
Homepage URL (2)：
http://www.riem.nagoya-u.ac.jp/4/mnd/index.html
,
http://www.riem.nagoya-u.ac.jp/4/mnd/index_en.html
Research field (3)：
Neuropathology
, Functional biochemistry
, Pathobiochemistry
Research keywords (8)：
Neurodegenerative diseases
, Mitochondria-associated membranes (MAM)
, Mouse models
, Protein aggregation
, Protein engineering
, Amyotrophic lateral sclerosis (ALS) / Frontotemporal lobar degeneration (FTLD)
, TAR DNA-binding protein 43 (TDP-43)
, Cu/Zn superoxide dismutase (SOD1)
Research theme for competitive and other funds (12)：
- 2023 - 2026 TDP-43単量体の細胞質における凝集機序の解明
- 2019 - 2024 タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発
- 2022 - 2023 Development of a novel mouse model recapitulates ALS pathology on oligodendrocytes
- 2020 - 2022 Analysis of a novel mechanism for maintenance of mitochondria-endoplasmic reticulum contact
- 2017 - 2021 Grant #17H04986
- 2019 - 2020 Development of the therapeutic strategy for ALS by preventing disruption of organelle communication
- 2014 - 2018 Elucidating pathomechanism of ALS through the abnormality in astrocytes
- 2015 - 2017 Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
- 2013 - 2017 Disruption of mitochondria-associated membrane in neurodegenerative disease
- 2015 - 2016 The physiological role of Cystatin C in Amyotrophic Lateral Sclerosis
- 2011 - 2016 Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction
- 2009 - 2011 ニューログロビンの細胞死抑制機構の解明と新規機能の探索
Show all
Papers (34)：
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Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C Saido, Takashi Saito, Koji Yamanaka. Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease. Journal of neuroinflammation. 2024. 21. 1. 55-55
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Okiru Komine, Syuhei Ohnuma, Kunihiko Hinohara, Yuichiro Hara, Mayuko Shimada, Tomohiro Akashi, Seiji Watanabe, Akira Sobue, Noe Kawade, Tomoo Ogi, et al. Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. iScience. 2024. 27. 2. 108872-108872
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Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, et al. Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 47. e2315347120
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Kotaro Oiwa, Seiji Watanabe, Kazunari Onodera, Yohei Iguchi, Yukako Kinoshita, Okiru Komine, Akira Sobue, Yohei Okada, Masahisa Katsuno, Koji Yamanaka. Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis. Science Advances. 2023. 9. 31
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Kei Hashimoto, Seiji Watanabe, Masato Akutsu, Norifumi Muraki, Hiroaki Kamishina, Yoshiaki Furukawa, Koji Yamanaka. Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation. The Journal of biological chemistry. 2023. 299. 6. 104798-104798
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MISC (9)：
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渡邊 征爾, 山中 宏二. 筋萎縮性側索硬化症におけるMAMの破綻. 実験医学(増刊). 2019. 37. 12. 138-144
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渡邊 征爾, 山中 宏二. 第7回 筋萎縮性側索硬化症(ALS). 和光純薬時報. 2018. 86. 4. 18-20
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Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K. Collapse of mitochondria-associated membrane as common pathomechanism for amyotrophic lateral sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017. 381. 104-104
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Nishino K, Watanabe S, Komine O, Yamanaka K. Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction. Journal of the Neurological Sciences. 2017. 381. 570
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徳田栄一, 森崎祐太, 三澤日出巳, 渡邊征爾, 山中宏二, 大原慎司, 古川良明. 筋萎縮性側索硬化症における変異SOD1オリゴマーの免疫化学的な検出. 日本薬学会年会要旨集(CD-ROM). 2017. 137th. ROMBUNNO.27I-am08
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Lectures and oral presentations (10)：
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Monomerization of TDP-43 is akey determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis.
(Japan-UK Neuroscience Symposium 2023)
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A novel role of the mitochondria-associated membrane against proteostatic stress
(The 66th Annual Meeting of the Japanese Society for Neurochemistry 2023)
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TANK-binding kinase 1 (TBK1) induces cellular proteostatic stress response at the mitochondria-associated membrane
(The 95th Annual Meeting of the Japanese Biochemical Society 2022)
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アグリソーム形成と液-液相分離は独立してTDP-43凝集体の形成を引き起こす
(第62回 日本神経学会 シンポジウム 2021)
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Disruption of the mitochondria-associated membranes in motor neuronal degeneration
(The 93rd Annual Meeting of the Japanese Biochemical Society 2020)
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Education (2)：
- 2007 - 2012 The University of Tokyo Graduate School of Arts and Sciences Department of Life Sciences
- - 2007 The University of Tokyo Faculty of Arts and Sciences
Professional career (1)：
Work history (5)：
- 2023/04 - 現在 Nagoya University Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine Lecturer
- 2014/04 - 2023/03 Nagoya University Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine Assistant Professor
- 2013/11 - 2014/03 Nagoya university Department of Neuroscience and Pathobiology, Research Institute for Environmental Medicine Researcher
- 2012/04 - 2013/10 RIKEN Laboratory for Motor Neuron Disease, BSI Researcher
- 2009/04 - 2012/03 JSPS Research Fellow
Awards (2)：
- 2017/09 - Research Institute of Environmental Medicine, Nagoya University Young Investigator's Award
- 2009/03 - Graduate School of Arts & Sciences, The University of Tokyo Incentive Award, Department of Life Sciences
Association Membership(s) (3)：
THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
, THE JAPAN NEUROSCIENCE SOCIETY
, THE JAPANESE BIOCHEMICAL SOCIETY
