Rchr
J-GLOBAL ID：201301024430330796   Update date: May. 20, 2024

Saito Tsuyoshi

サイトウ ツヨシ | Saito Tsuyoshi
Affiliation and department：
University of Tsukuba Institute of Medicine/ International Institute for Integrative Sleep Medicine (IIIS)

About University of Tsukuba Institute of Medicine/ International Institute for Integrative Sleep Medicine (IIIS)


Job title： Associate Professor
Research field  (1)： Bioorganic chemistry
Research keywords  (9)： Opioid ,  Chemical Biology ,  Natural Product Synthesis ,  Sleep/wake ,  Orexin ,  G-protein coupled receptor ,  Organic Electrochemistry ,  Bioluminescence ,  Medicinal Chemistry
Research theme for competitive and other funds  (13)：
  • 2021 - 2024 Multi-scale platform for untangling physiological complexity
  • 2021 - 2024 Multi-scale platform for untangling physiological complexity
  • 2021 - 2024 Construction of morphinan-based focused library
  • 2019 - 2024 Structural analysis of G protein/Arrestin-GPCR complex for development of biased ligands
  • 2020 - 2023 Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors
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Papers (74)：
  • Koustav Roy, Xuzhao Zhou, Rintaro Otani, Ping-Chuan Yuan, Shuji Ioka, Kaspar E. Vogt, Tamae Kondo, Nouran H. T. Farag, Haruto Ijiri, Zhaofa Wu, et al. Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors. Nature Communications. 2024. 15. 1
  • Kenta Maeda, Tomoya Sugai, Akihisa Tokuda, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Noriki Kutsumura. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands. Bioorganic & medicinal chemistry letters. 2024. 99. 129611-129611
  • Keita Kajino, Akihisa Tokuda, Tsuyoshi Saitoh. Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology. The Journal of Biochemistry. 2024
  • Ayako Kawaminami, Daisuke Yamada, Toshinori Yoshioka, Azumi Hatakeyama, Moeno Nishida, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Akiyoshi Saitoh. The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala. Neuropsychopharmacology reports. 2023
  • Saito, Tsuyoshi. Selective electro-oxidation of cumene utilizing a flow reactor equipped with diamond electrodes. Current Research in Green and Sustainable Chemistry. 2023. 7. 100378
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MISC (20)：
  • 斉藤毅. Discovery of OX1R specific antagonists bearing morphinan skeleton. Chemical Times. 2022. 2022. 2. 9-15
  • 斉藤毅. 独自骨格を用いる三次元ライブラリーアプローチによる新規オレキシン受容体リガンドの創製. 日本応用酵素協会誌. 2022. 56. 81-81
  • 斉藤 毅. 我が輩はボブである. ファルマシア. 2022. 58. 1. 59_1-59_1
  • Takashi Yamamoto, Tsuyoshi Saitoh, Yasuaki Einaga, Shigeru Nishiyama. Anodic Oxidation of Phenols: A Key Step for the Synthesis of Natural Products. The Chemical Record. 2021. 21. 9. 2254-2268
  • 斉藤毅. オレキシン受容体アゴニストの創製と薬理作用の解明. 日本応用酵素協会誌. 2021. 55. 62-63
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Patents (13)：
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Books (4)：
  • 日本応用酵素協会誌
    公益財団法人 日本応用酵素協会 2023
  • Diamond Electrodes Fundamentals and Applications
    Springer Nature Singapore Pte Ltd. 2022 ISBN:9789811678332
  • New Frontiers in Organic Electrosynthesis
    2021 ISBN:9784781316260
  • 天然物の化学 II
    東京化学同人 2018 ISBN:9784807915057
Lectures and oral presentations  (83)：
  • 三次元配向制御に立脚したオレキシン受容体作動薬の創製
    (日本薬学会第143年会)
  • 鎮静作用を分離したκオピオイド受容体作動薬の創製
    (日本薬学会第143年会)
  • ヘテロビシクロ[2.2.2]オクタン骨格を有する新規κオピオイド受容体作動薬の創製
    (日本薬学会第143年会)
  • フロー合成を用いたTriMERの効率的合成法の開発
    (日本薬学会第143年会)
  • オレキシン1受容体を介する疼痛制御メカニズムの解析
    (日本薬学会第143年会)
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Education (2)：
  • 2007 - 2009 Keio University School of Fundamental Science and Technology
  • 2003 - 2007 Keio University Faculty of Science and Technology Department of Chemistry
Work history (9)：
  • 2023/04 - 現在 University of Tsukuba Institute of Medicine/ International Institute for Integrative Sleep Medicine (IIIS)
  • 2022/04 - 現在 筑波大学 国際統合睡眠医科学研究機構 主任研究者
  • 2015/10 - 現在 University of Tsukuba Master's/Doctoral Program in Life Science Innovation Assistant Professor (Shareing)
  • 2023/03 - 2023/03 University of Tsukuba International Institute for Integrative Sleep Medicine Associate Professor
  • 2020/04 - 2023/03 University of Tsukuba Graduate School of Comprehensive Human Sciences Assistant Professor
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Committee career (5)：
  • 2022/04 - 現在 GPCR研究会 事務局
  • 2013 - 現在 公益社団法人電気化学会有機電子移動化学研究会 幹事
  • 2013 - 日本化学会第94春季年会 プログラム小委員会委員
  • 2011 - 日本化学会第92春季年会 会場小委員会委員
  • 2011 - 10th International Symposium on Organic Reactions Local Committee
Awards (16)：
  • 2023/11 - 筑波大学医学医療系 医学医療系優秀教員(研究)
  • 2023/07 - TRiSTAR (Top Runners in Strategy of Transborder Advanced Researches) Fellow
  • 2022 - University of Tsukuba TRiSTAR (Top Runners in Strategy of Transborder Advanced Researches) Pre Fellow
  • 2019 - Royal Society of Chemistry Reaction Chemistry & Engineering poster prize at SelectBIO Flow Chemistry Asia 2019 Natural Product Synthesis with Electrochemical Flow Reactions
  • 2017 - 筑波大学 若手研究奨励賞
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Association Membership(s) (9)：
有機電子移動化学研究会 ,  The Japanese Association for the Pursuit of New Bioactive Resources ,  The Pharmaceutical Society of Japan, Division of Medicinal Chemistry ,  電気化学会有機電子移動化学研究会 ,  FLOWST ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN
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