Rchr
J-GLOBAL ID:201301026023817381
Update date: Nov. 11, 2024
Nakamura Takashi
ナカムラ タカシ | Nakamura Takashi
Affiliation and department:
Job title:
Professor
Research field (5):
Clinical pharmacy
, Biomedical engineering
, Biomaterials
, Tumor diagnostics and therapeutics
, Tumor biology
Research keywords (13):
免疫細胞療法
, がんワクチン
, ナノ粒子
, DDS
, がん免疫療法
, 核酸
, アジュバント
, 膀胱がん
, がん免疫
, ワクチン
, ナノメディシン
, リポソーム
, ドラッグデリバリーシステム
Research theme for competitive and other funds (16):
- 2024 - 2028 ナノDDSによる生体内機能強化NK細胞の創出と新規がん免疫療法基盤の構築
- 2023 - 2028 Activated mRNA delivery system based on core-shell structured LNP with smart polymers
- 2023 - 2026 炎症性腸疾患におけるスフィンゴ糖脂質による治療を目指した基礎的研究
- 2022 - 2025 ナノDDSで挑む腫瘍血管内皮細胞を標的とした新機軸のがん治療法の開発
- 2020 - 2023 PD-1抗体への獲得抵抗性を攻略する記憶NK細胞誘導型ナノがん免疫療法の開発
- 2019 - 2023 Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking steps
- 2018 - 2021 Development of nano cancer immunotherapy based on immune status in tumor
- 2017 - 2020 腫瘍リンパ節標的型クラスターナノDDSによる複合がん免疫療法
- 2015 - 2018 Lipid immunity in rhesus monkeys and development of a new anti-tuberculosis vaccine
- 2016 - 2018 c-di-GMP搭載脂質ナノ粒子と抗PD-1抗体による複合的がん免疫療法
- 2014 - 2017 Development of nano medicine for anti-bladder cancer based on human immunology
- 2014 - 2016 The effect of intracellular trafficking of BCG-CWS loaded nanoparticles on anti-bladder cancer activity
- 2012 - 2015 Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity
- 2010 - 2014 MENDで拓く遺伝子治療への道:遺伝子の運び屋からナノマシンへ
- 2012 - 2014 Induction of antitumor immunity by nanoparticle incorporating alpha-galactocylceramide
- 2007 - 2009 細胞内生態解析に基づいた樹状細胞選択的DNAワクチンの開発
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Papers (72):
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Mahmoud M. Abd Elwakil, Ryota Suzuki, Alaa M. Khalifa, Rania M. Elshami, Takuya Isono, Yaser H.A. Elewa, Yusuke Sato, Takashi Nakamura, Toshifumi Satoh, Hideyoshi Harashima. Harnessing Topology and Stereochemistry of Glycidylamine-Derived Lipid Nanoparticles for in Vivo mRNA Delivery to Immune Cells in Spleen and Their Application for Cancer Vaccination. Advanced Functional Materials. 2023
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Takashi Nakamura, Taisei Nakade, Yusuke Sato, Hideyoshi Harashima. Delivering mRNA to a human NK cell line, NK-92 cells, by lipid nanoparticles. International journal of pharmaceutics. 2023. 636. 122810-122810
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Alaa M Khalifa, Takashi Nakamura, Yusuke Sato, Takanori Sato, Mamoru Hyodo, Yoshihiro Hayakawa, Hideyoshi Harashima. Interval- and cycle-dependent combined effect of STING agonist loaded lipid nanoparticles and a PD-1 antibody. International journal of pharmaceutics. 2022. 624. 122034-122034
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Takashi Nakamura, Yusuke Sato, Yuma Yamada, Mahmoud M Abd Elwakil, Seigo Kimura, Mahmoud A Younis, Hideyoshi Harashima. Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines. Advanced drug delivery reviews. 2022. 188. 114417-114417
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Takafumi Fukui, Hironao Tateno, Takashi Nakamura, Yuma Yamada, Yusuke Sato, Norimasa Iwasaki, Hideyoshi Harashima, Ken Kadoya. Retrograde Axonal Transport of Liposomes from Peripheral Tissue to Spinal Cord and DRGs by Optimized Phospholipid and CTB Modification. International journal of molecular sciences. 2022. 23. 12
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MISC (17):
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杉原崚太, 日比野光恵, 真栄城正寿, 渡慶次学, 中村孝司, 原島秀吉, 山田勇磨. 難水溶性物質CoQ10を搭載可能な脂質ナノ粒子設計の検討. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
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小室茉莉子, 永根大幹, 丹羽智瑛, 宮本貴祥, 遠藤力斗, 中村孝司, 原島秀吉, 相原尚之, 上家潤一, 山下匡. 炎症性腸疾患におけるグルコシルセラミドの機能解析. 日本酸化ストレス学会学術集会プログラム・抄録集. 2021. 74th (CD-ROM)
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小室茉莉子, 永根大幹, 宮本貴祥, 丹羽智瑛, 遠藤力斗, 中村孝司, 原島秀吉, 相原尚之, 上家潤一, 山下匡. 炎症性腸疾患におけるグルコシルセラミドの機能解析. 日本生化学会大会(Web). 2021. 94th
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中村孝司, 河合美典, 佐藤悠介, 真栄城正寿, 渡慶次学, 原島秀吉. Properties of lipid nanoparticles affecting their lymph node transitivity and distribution. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
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永根大幹, 山門みのり, 水野愛理, 遠藤力斗, 中村孝司, 原島秀吉, 相原尚之, 上家潤一, 山下匡. T細胞のグルコシルセラミドは炎症性大腸炎を抑制する. 日本酸化ストレス学会学術集会プログラム・抄録集. 2020. 73rd
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Education (2):
- 2007 - 2010 Hokkaido University Graduate School of Life Science Division of Life Sciences
- 2005 - 2007 Hokkaido University
Professional career (1):
- PhD (Hokkaido University)
Work history (6):
Awards (6):
Association Membership(s) (2):
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