Mishima Eikan

Mishima Eikan | Mishima Eikan

Affiliation and department：
Job title： Senior scientist
Other affiliations (1)：

Tohoku University Graduate School of Medicine Division of Nephrology, Endocrinology and Vascular Medicine

Research field (3)： Molecular biology , Nephrology , Metabolism and endocrinology

Research keywords (10)： Ferroptosis , Lipie peroxidation , Cell death , vitamin K , Oxidative stress , Metabolome , Microbiota , Nephrology , Hypertension , Endocrinology

Research theme for competitive and other funds (17)：

2020 - 2023 ながはまコホートおよび佐渡コホートのゲノム情報解析による、尿酸値関連変異の探索
2021 - 2023 Lipid radicals in regulation of ferroptosis
2023 - 生命進化における抗フェロトーシスビタミンとしてのビタミンKの役割と治療応用
2016 - 2022 応用酵素協会成人病の病因・病態の解明に関する研究助成
2018 - 2021 Gut-renal axis: microbiota and chronic kidney disease

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Papers (146)：

Junya Ito, Toshitaka Nakamura, Takashi Toyama, Deng Chen, Carsten Berndt, Gereon Poschmann, André Santos Dias Mourão, Sebastian Doll, Mirai Suzuki, Weijia Zhang, et al. PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Molecular Cell. 2024
Akiyo Sekimoto, Yoko Takaso, Haruka Saruyama, Masataka Ookawa, Mari Yamamoto, Takafumi Toyohara, Daisuke Saigusa, Tomoko Fukuuchi, Mayu Otsuka, Yui Fushiki, et al. Impacts of low birthweight on kidney development and intergenerational growth of the offspring. iScience. 2024. 111159-111159
Eikan Mishima. Targeting ferroptosis for treating kidney disease. Clinical and Experimental Nephrology. 2024
逸見佳宣, 緒方星陵, 井田智章, 三枝大輔, 三島英換, 高橋信行, 魏范研, 赤池孝章, 佐藤恵美子. 慢性腎臓病の早期診断法確立を目指した硫黄代謝物に基づく呼気オミックス. 日本腎臓学会誌. 2024. 66. 4. 632-632
Raphaël Rodriguez, Tatiana Cañeque, Leeroy Baron, Sebastian Müller, Alanis Carmona, Ludovic Colombeau, Antoine Versini, Marie Sabatier, Julio Sampaio, Eikan Mishima, et al. Activation of lysosomal iron triggers ferroptosis in cancer. 2024

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MISC (74)：

三澤計治, 三澤計治, 三澤計治, 三澤計治, 三島英換, 長谷川嵩矩, 大内基司, 小島要, 河合洋介, 松尾雅文, et al. まれな変異に重点を置いた尿酸値の遺伝率の研究. 日本人類遺伝学会大会プログラム・抄録集. 2021. 66th (CD-ROM)
金光祥臣, 三島英換, 松本洋太郎, 前川正充, 前川正充, 菊地晃一, 三枝大輔, 阿部高明, 阿部高明, 眞野成康, et al. Quantitative analysis of gut microbiota-derived metabolites by LC-MS sheds light on the gut-kidney axis on kidney disease. JSBMS Letters. 2021. 46. Supplement
Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishima, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, et al. Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. Biochemical and biophysical research communications. 2020. 525. 3. 773-779
Eikan Mishima, Naohiko Anzai, Mariko Miyazaki, Takaaki Abe. Uric acid elevation by favipiravir, an antiviral drug. Tohoku Journal of Experimental Medicine. 2020. 251. 2. 87-90
菊地晃一, 三枝大輔, 金光祥臣, 松本洋太郎, 三瀬広記, 中村智洋, 三島英換, 豊原敬文, 鈴木健弘, 寳澤篤, et al. 糖尿病性腎症の発症・進展予測マーカーとしてのフェニル硫酸の有用性. 日本腎臓学会誌(Web). 2020. 62. 4

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Patents (2)：

フェロトーシス抑制剤
フェロトーシス抑制薬の同定

Professional career (1)：

医学博士 (東北大学)

Work history (14)：

2023/03 - 現在ヘルムホルツセンター・ミュンヘン上級研究員
2020/10 - 現在 Tohoku University of Medicine Division of Nephrology, Rheumatology and Endocrinology Researcher
2020/10 - 2023/02 Helmholtz Zentrum München Institute of Metabolism and Cell Death Guest scientist
2019/04 - 2020/09 Tohoku University Graduate School of Medicine University Hospital Nephrology, Endocrinology and Vascular Medicine Associate professor / lecturer
2016/02 - 2019/03 Tohoku University Graduate School of Medicine Division of Nephrology, Endocrinology and Vascular Medicine Assistant Professor

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Committee career (10)：

2020 - 現在 Editorial borad member, BMC Nephrology
2020 - 現在日本高血圧学会国際交流委員会
2019 - 現在日本腎臓学会広報委員会
2023 - 2024 日本高血圧学会 U-45委員会
2018 - 2024 日本腎臓学会 JSN Next Frontiers 2028委員会

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Awards (33)：

2023 - 三島海雲学術賞
2023 - 日本ビタミン学会奨励賞
2023 - 安藤百福賞発明発見奨励賞
2023 - JSN Oshima Award
2022 - Helmholtz Munich Best Paper Award 2022

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Association Membership(s) (9)：

THE JAPANESE SOCIETY FOR DIALYSIS THERAPY , JAPAN PRIMARY CARE ASSOCIATION , 日本心血管内分泌代謝学会 , THE JAPAN SOCIETY OF HUMAN GENETICS , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , The Japan Endocrine Society , The Japanese Society of Hypertension , JAPANESE SOCIETY OF NEPHROLOGY , 分子生物学会

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