Tanaka Seiji

タナカセイジ | Tanaka Seiji

Affiliation and department：
Homepage URL (1)： https://www.kochi-tech.ac.jp/profile/ja/tanaka-seiji.html

Research field (4)： Molecular biology , Cell biology , Genetics , Structural biochemistry

Research keywords (30)： DNA複製 , CDK , 細胞周期 , がん , 出芽酵母 , ゲノム不安定化 , 複製開始 , Sld2 , pre-RC , G1期CDK , S期 , nim1^1 , DNA複 , NIK1 , ゲノムの安定性 , M期 , G1期サイクリン , DDK , 時間的制御プログラム , S.cerevisiae , G2 , GCR , 染色体DNA複製 , 蛋白質キナーゼ , サブトラクション , cDNAライブラリー , チェックポイント , 分裂酵母 , 遺伝子破壊 , サイクリンG

Research theme for competitive and other funds (31)：

2022 - 2025 ゲノム「改編」とゲノム「安定維持」を両立可能とさせる分子メカニズム
2015 - 2017 Molecular mechanism for the reversible genome modulation
2014 - 2016 DNA再複製防止機構からのエスケープとゲノム再編
2012 - 2016 Regulation of the initiation of DNA replication and its higher order regulation
2013 - 2015 DNA複製開始タイミングを規定する因子による染色体クロマチン制御とDNA修復反応

2010 - 2011 細胞周期における染色体DNA複製の高次制御機構

2008 - 2011 Analysis of the molecular mechanism of the initiation of chromosomal DNA replication in eukaryotes

2008 - 2009 Destabilisation of genome by the failure in the regulatory system of chromosome DNA replication which is controlled by cell cycle regulator, CDK

2006 - 2007 Analysis of JET1 mutant, which does not require CDK activity in the initiation of DNA replication

2006 - 2007 G1期サイクリン発現によるゲノム不安定化の分子機構

2003 - 2006 Molecular mechanism of assembly of replication proteins at replication origins in eukaryotes

2005 - 2005 細胞周期制御因子G1期サイクリンの発現によるゲノム不安定化の分子機構

2004 - 2005 Regulatory mechanisms for the initiation of DNA replication in eukaryotes.

2004 - 2005 CDKによるDNA複製開始制御機構の解明

2004 - 2004 G1期サイクリンの発現によるゲノム不安定化の分子機構

1999 - 2003 出芽酵母Dpb11,RFCの複製モニター機構

1998 - 1998 真核生物におけるDNA複製複合体の分子構築と機能解析

1998 - 1998 重差分化法による減数分裂特異的遺伝子の包括的単離と機能解析

1998 - 1998 細胞増殖を制御する新しい細胞周期調節遺伝子群の単離と機能解析

1996 - 1998 Systematic isolation and analysis of novel genes that control cell cycle and cell growth.

1997 - 1997 真核生物におけるDNA複製複合体の分子構築と機能解析

1997 - 1997 分裂酵母における減数分裂特異的転写カスケードの分子遺伝学的解析

1997 - 1997 細胞増殖を制御する新しい細胞周期調節遺伝子群の単離と機能解析

1995 - 1997 Development and application of ESS method

1996 - 1996 真核生物におけるDNA複製複合体の分子構築と機能解析

1996 - 1996 分裂酵母における減数分裂特異的転写カスケードの分子遺伝学的解析

1996 - 1996 核内蛋白質キナーゼGAK・サイクリンG複合体の構造と動態

1996 - 1996 細胞増殖を制御する新しい細胞同期調節遺伝子群の単離と機能解析

1995 - 1995 出芽酵母の細胞周期特異的に発現する新規キナーゼ遺伝子PAK1の解析

1995 - 1995 減数分裂前DNA合成開始制御とG1期調節の分子機構

1993 - 1995 Cloning and functional analusis of cell-cycle regulatory genes by complementation cloning.

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Papers (34)：

Seiji Tanaka, Shiho Ogawa. Dimerization of Firing Factors for Replication Origin Activation in Eukaryotes: A Crucial Process for Simultaneous Assembly of Bidirectional Replication Forks?. Biology. 2022. 11. 6
Seiji Tanaka. Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins. Genetics. 2020. in press
Seiji Tanaka. An efficient method for the isolation of interaction-null/impaired mutants using the yeast two-hybrid technique. Genes to Cells. 2019
Riki Terui, Koji Nagao, Yoshitaka Kawasoe, Kanae Taki, Torahiko L. Higashi, Seiji Tanaka, Takuro Nakagawa, Chikashi Obuse, Hisao Masukata, Tatsuro S. Takahashi. Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1. Genes and Development. 2018. 32. 11-12. 806-821
Mayumi Miyazawa-Onami, Hiroyuki Araki, Seiji Tanaka. Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer. EMBO REPORTS. 2017. 18. 10. 1752-1761

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MISC (6)：

Seiji Tanaka. Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins. BioRxiv. 2020
Seiji Tanaka, Mayumi Miyazawa-Onami, Akari Hosoe, Hiroyuki Araki. Relationship between the initiation reaction of DNA replication and chromatin regulator in eukaryotes. GENES & GENETIC SYSTEMS. 2016. 91. 6. 340-340
釣本敏樹, 沖本寛子, 藤澤遼, 田栗蘭, 大橋英治, 田中誠司, 荒木弘之. DNAポリメラーゼεとPCNAローダーCtf18-RFCのホロ複合体形成とその機能. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th
釣本敏樹, 大橋英治, 沖本寛子, 田中誠司, 荒木弘之. DNA複製装置と染色体接着装置のクロストーク. 日本分子生物学会年会プログラム・要旨集(Web). 2012. 35th
田中誠司, 荒木弘之. 真核細胞の細胞周期制御機構と染色体DNA複製. 遺伝. 2009. 63. 51-58

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Books (4)：

Methods in Molecular Biology, Yeast Protocols (4th Ed.)
Springer 2020
'Role of CDK in Replication Initiation' in 'The Initiation of DNA Replication in Eukaryotes'
Springer International Publishing 2016
DNA replication / edited by Stephen D. Bell, Marcel Me ́chali, and Melvin L. DePamphilis. Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication
COLD SPRING HARBOR LABORATORY PRESS ・USA 2013 ISBN:9781936113484
実験医学 CDKによる染色体DNAの複製開始制御機構
2007

Lectures and oral presentations (11)：

Interaction between replication firing factor Sld3 and histone acetyltransferase Esa1 promotes the activation of subset of replication origins in budding yeast
(Cold Spring Harbor Laboratory meeting: DNA replication and genome stability 2019)
Interaction between replication initiation factor Sld3 and histone acetyltransferase Esa1 promotes the activation of subset of replication origins in budding yeast
(2018)
Interaction between replication initiation factor Sld3 and histone acetyltransferase Esa1 promotes the activation of subset of replication origins in budding yeast
(EMBO Workshop DNA replication, chromosome segregation and fate decisions 2018)
出芽酵母染色体DNA複製開始反応とクロマチン制御因子
(酵母遺伝学フォーラム第51回研究報告会 2018)
DNA複製開始反応とクロマチン制御因子
(第6回バイオシグナル研究会「遺伝情報の維持伝承とバイオシグナル」 2018)

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