Sakurai Yu

Affiliation and department：
Job title： Lecturer

Research field (1)： Nano/micro-systems

Research theme for competitive and other funds (9)：

2023 - 2027 Innovation of On-demand DDS platform of RNA therapeutics based on endothelial ATLAS
2021 - 2025 Ready-tp-Use RNA-drug discovery for the acceleration of personalized cancer vaccine
2021 - 2024 Development of photoimmunotherapy via O-glycans and siRNA delivery system using iRGD nanoparticles in lung cancer
2020 - 2022 Development of ligand modification onto the nanoparticle via click reaction and systematic evaluation
2018 - 2020 Development of new therapy for lung-metastasis cancer by selecitve siRNA delivery to vasculature

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Papers (74)：

Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi, et al. The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles. Pharmaceutics. 2024. 16. 2
Yi Liu, Miho Suzuoki, Hiroki Tanaka, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita. Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines. Biological & pharmaceutical bulletin. 2024. 47. 3. 698-707
Jessica Anindita, Hiroki Tanaka, Ryotaro Oyama, Shinya Hagiwara, Daiki Shirane, Sakura Taneichi, Yuta Nakai, Kota Tange, Hiroto Hatakeyama, Yu Sakurai, et al. Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds. Pharmaceutics. 2023. 15. 12
Ryotaro Oyama, Harumichi Ishigame, Hiroki Tanaka, Naho Tateshita, Moeko Itazawa, Ryosuke Imai, Naomasa Nishiumi, Jun-ichi Kishikawa, Takayuki Kato, Jessica Anindita, et al. An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses. ACS Nano. 2023
Masaki Gomi, Yuka Nakayama, Yu Sakurai, Ryotaro Oyama, Koki Iwasaki, Mizuki Doi, Yi Liu, Mizuho Hori, Himeka Watanabe, Kohei Hashimoto, et al. Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis. Pharmaceuticals (Basel, Switzerland). 2023. 16. 9

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MISC (24)：

山本理奈, 藤田翔也, 田中浩揮, 櫻井遊, 中井悠太, 丹下耕太, 金沢貴憲, 秋田英万. 脳を標的とするNose-to-Brain型mRNA送達技術の開発. 遺伝子・デリバリー研究会シンポジウム要旨集. 2022. 21st (CD-ROM)
山川拓真, 田中浩揮, 萩原伸哉, 櫻井遊, 佐々木香純, 米持悦生, 福澤薫, 中井悠太, 丹下耕太, 秋田英万, et al. Ready-to-Use型mRNA内封脂質ナノ粒子製剤の物性評価. 遺伝子・デリバリー研究会シンポジウム要旨集. 2022. 21st (CD-ROM)
田中浩揮, 萩原伸哉, 山川拓真, 櫻井遊, 米持悦生, 福澤薫, 中井悠太, 丹下耕太, 秋田英万, 秋田英万. Development of Ready-to-Use type LNPs. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2022. 7th
山川拓真, 田中浩揮, 萩原伸哉, 櫻井遊, 佐々木香純, 米持悦生, 福澤薫, 中井悠太, 丹下耕太, 秋田英万, et al. Evaluation of Physical Properties of Ready-to-Use Formulations of Lipid Nanoparticles Enclosed in mRNA. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2022. 7th
山本理奈, 藤田翔也, 田中浩揮, 櫻井遊, 中井悠太, 丹下耕太, 金沢貴憲, 秋田英万. 脳を標的とするNose-to-Brain型mRNA送達技術の開発. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2022. 43rd

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Professional career (1)：

博士(薬科学) (北海道大学)

Work history (5)：

2021/10 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences Lecturer
2021/04 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences
2018/04 - 2021/03 Chiba University Graduate School of Pharmaceutical Sciences
2013/04 - 2018/03 Hokkaido Uni Graduate School of Pharmaceutical Sciences
2010/04 - 2013/03 Japan Society for the Promotion of Science

Awards (6)：

2023/05 - 公益財団法人インテリジェント・コスモス学術振興財団第22回インテリジェント・コスモス奨励賞
2022/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists 2022
2018/05 - 日本薬学会北海道支部奨励賞機能性素子を用いたがん微小環境を標的とするsiRNA 送達技術の開発
2017/01 - 北海道大学北海道大学研究総長賞(奨励賞)
2009/10 - Asian Federation for Pharmaceutical Sciences The AFPS Nagai-Shunkri Pre-doctoral Best Paper Award DEVELOPMENT OF EFFICIENT SIRNA DELIVERY SYSTEM TO TUMOR CELLS BY COMBINING OCTAARGININE, GALA AND ENZYMATICALLY-CLEAVABLE PEG-LIPID

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