Kato Taisuke

カトウタイスケ | Kato Taisuke

Affiliation and department：
Job title： Associate professor

Research field (2)： Molecular biology , Neuroscience - general

Research keywords (6)： Polyglutamine diseases , Genome editing , Small vessel disease , 包括脳ネットワーク , amyotrophic lateral sclerosis , CARASIL

Research theme for competitive and other funds (10)：

2022 - 2025 脳小血管線維化促進細胞の同定による脳小血管老化の解明
2022 - 2025 脳小血管の細胞外基質の摂動を起こす細胞群の同定と、その制御機構の解読
2022 - 2025 脳小血管線維化促進細胞の同定による脳小血管老化の解明
2021 - 2024 細胞老化から解く、真のTDP-43プロテイノパチー分子機構への挑戦
2019 - 2022 Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.

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Papers (53)：

Shoichiro Ando, Rie Saito, Sho Kitahara, Masahiro Uemura, Yuya Hatano, Masaki Watanabe, Taisuke Kato, Yosuke Ito, Atchayaram Nalini, Tomohiko Ishihara, et al. “Chocolate Chip Sign” on Susceptibility-Weighted Imaging. Neurology Genetics. 2025. 11. 2
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, et al. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Nature Communications. 2024. 15. 1
坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 上野将紀. TDP-43は運動回路の変性を誘導するために異なって伝播する(TDP-43 differentially propagates to induce degeneration in the motor circuit). Dementia Japan. 2023. 37. 4. 680-680
Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno. TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models. Acta neuropathologica. 2023
Masahiro Uemura, Sho Kitahara, Taisuke Kato, Hiroaki Nozaki, Shoichiro Ando, Tomohiko Ishihara, Osamu Onodera. Inappropriate interpretation of non-pathogenic HTRA1 variant as pathogenic. Annals of clinical and translational neurology. 2023. 10. 7. 1261-1262

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MISC (39)：

坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, et al. TDP-43 differentially propagates to induce degeneration in the motor circuit. Dementia Japan. 2023. 37. 4
森秀樹, 坪口晋太朗, 佐藤時春, 中村由香, 加藤泰介, 須貝章弘, 小野寺理, 上野将紀. TDP-43変異型により異なる病態進展特性の解析. Dementia Japan. 2023. 37. 4
加藤泰介, 眞鍋理一郎, 五十嵐博中, 亀谷富由樹, 齊藤聡, 畠野雄也, 安藤昭一朗, 福永雅喜, 佐藤俊哉, 齋藤理恵, et al. 遺伝性脳小血管病モデルから見えてきたmatrisomeの破綻と治療法の展望. Dementia Japan. 2022. 36. 4
加藤泰介, 眞鍋理一郎, 五十嵐博中, 亀谷富由樹, 齊藤聡, 畠野雄也, 安藤昭一朗, 福永雅喜, 佐藤俊哉, 齋藤理恵, et al. Matrisomeの擾乱から見た脳小血管病の分子病態と治療法への展望. Dementia Japan. 2022. 36. 4
TSUBOGUCHI Shintaro, NAKAMURA Yuka, ISHIHARA Tomohiko, KATO Taisuke, KOYAMA Akihide, SATO Tokiharu, YOSHIDA Yutaka, UENO Masaki, ONODERA Osamu. Spreading of TDP-43 via direct corticospinal connections in mouse models. 日本神経学会学術大会プログラム・抄録集. 2020. 61st

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Lectures and oral presentations (4)：

Gene therapy for DRPLA model mice by AAV-delivered CRISPR / Cas9
(Genome Engineering: From Mechanisms to Therapies, Keystone Symposia Conference 2019)
Therapeutic strategy based on genome editing by CRISPR/Cas9 for polyglutamine disease using DRPLA model
(Advances in Neurodegenerative Disease Research and Therapy. Keystone Symposia Conference. 2018)
Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels.
(2017)
Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels.
(Neuroscience2017 2017)

Education (3)：

2006 - 2010 Niigata University Graduate School of Medical and Dental Sciences
2004 - 2006 Niigata University Graduate School of Medical and Dental Sciences
2000 - 2004 Niigata University Faculty of Agriculture Department of Applied Biological Chemistry

Professional career (1)：

医学博士 (Ph.D.) (新潟大学)

Work history (3)：

2022/04 - 現在新潟大学脳研究所分子神経疾患資源解析学分野准教授
2017/04 - 2022/03 Niigata University Brain Research Institute
2013/10 - 2016/03 Niigata University Brain Research Institute

Awards (2)：

2024/11 - 日本認知症学会学会賞
2014 - 包括型脳科学研究推進支援ネットワーク夏のワークショップ若手優秀発表賞受賞筋萎縮性側索硬化症運動神経細胞におけるTDP-43 mRNAの細胞内局在解析

Association Membership(s) (3)：

THE JAPAN NEUROSCIENCE SOCIETY , Japanese Society for Neurochemistry , Society for Neuroscience

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