Research field (2):
Molecular biology
, Neuroscience - general
Research keywords (6):
Polyglutamine diseases
, Genome editing
, Small vessel disease
, 包括脳ネットワーク
, amyotrophic lateral sclerosis
, CARASIL
Research theme for competitive and other funds (9):
2022 - 2025 脳小血管の細胞外基質の摂動を起こす細胞群の同定と、その制御機構の解読
2022 - 2025 脳小血管線維化促進細胞の同定による脳小血管老化の解明
2021 - 2024 細胞老化から解く、真のTDP-43プロテイノパチー分子機構への挑戦
2019 - 2022 Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.
2018 - 2021 Elucidation of the mechanism of gain-of-toxic function by abnormal subcellular localization of cerebral small vessel disease-related mutant TREX1
2017 - 2020 Tauopathy affecting astrocytes: diversity in the tau pathology and the astrocytic molecular feature
2016 - 2019 Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.
2014 - 2015 Impact of the excess TGFbeta signaling on blood vessel integrity in the brain
2011 - 2013 炎症による血液脳関門の破綻を転機としたCARASIL病態発症機序の解析
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Papers (51):
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, et al. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Nature Communications. 2024. 15. 1
Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno. TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models. Acta neuropathologica. 2023
Masahiro Uemura, Sho Kitahara, Taisuke Kato, Hiroaki Nozaki, Shoichiro Ando, Tomohiko Ishihara, Osamu Onodera. Inappropriate interpretation of non-pathogenic HTRA1 variant as pathogenic. Annals of clinical and translational neurology. 2023. 10. 7. 1261-1262
Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Ramil Gabdulkhaev, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, et al. Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 23. e2214652120
Gene therapy for DRPLA model mice by AAV-delivered CRISPR / Cas9
(Genome Engineering: From Mechanisms to Therapies, Keystone Symposia Conference 2019)
Therapeutic strategy based on genome editing by CRISPR/Cas9 for polyglutamine disease using DRPLA model
(Advances in Neurodegenerative Disease Research and Therapy. Keystone Symposia Conference. 2018)
Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels.
(2017)
Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels.
(Neuroscience2017 2017)
Education (3):
2006 - 2010 Niigata University Graduate School of Medical and Dental Sciences
2004 - 2006 Niigata University Graduate School of Medical and Dental Sciences
2000 - 2004 Niigata University Faculty of Agriculture Department of Applied Biological Chemistry
Professional career (1):
医学博士 (Ph.D.) (新潟大学)
Work history (3):
2022/04 - 現在 新潟大学脳研究所 分子神経疾患資源解析学分野 准教授
2017/04 - 2022/03 Niigata University Brain Research Institute
2013/10 - 2016/03 Niigata University Brain Research Institute