masanori koide

コイデマサノリ | masanori koide

Affiliation and department：
Job title：准教授

Research field (4)： Conservative dentistry and endodontics , Developmental dentistry , Oral medicine , Oral medicine (pathology)

Research keywords (30)：歯周病 , 骨吸収 , RANKL , OPG , 歯周組織再生 , 歯周炎モデル , 骨形成 , 歯槽骨吸収 , Caチャネル阻害剤 , Osteoclast , TRAF-2 , TRAF-6 , Caチャンネル阻害剤 , c-Jun , TNF , 1-beta-D-Arabinofuranosylcytosine , P. g. 菌 , Phenytoin , Osteoblast , 破骨細胞 , M-CSF , 骨芽細胞 , OIP-1 , マクロファージ , IL-1receptor type 2 , 樹状細胞 , 転写因子 , 大理石骨病 , IL-1β , 慢性歯周炎

Research theme for competitive and other funds (36)：

2022 - 2025 Elucidation of the mechanism of action of Siglec-15 antibody drugs in the treatment of secondary osteoporosis during growth and development
2021 - 2025 Anlysis of the RANKL-Siglec-15 signal molecular mechanism for alveolar bone regeneration
2021 - 2024 骨特異的Wntシグナル阻害分子スクレロスチンの臓器選択的がん転移に対する制御機構
2020 - 2023 Elucidation of unknown network mechanism of osteoprotegerin in bone, cardiovascular and digestive system
2020 - 2023 幹細胞の分化を司る組織常在型M3マクロファージとそのマスター転写因子の同定

2019 - 2022 Development of new therapeutic agents for bone and periodontal diseases based on the bone metabolism-uncoupling mechanisms

2019 - 2022 Development of a potential new marker of periodontal disease status based on serum IL-1 receptor accessory protein .

2018 - 2021 Functional role of cell migration factor LRP1 in periodontal tissue repair

2018 - 2021 Development of the new periodontal treatments based on the regulation of sclerostin secretion

2017 - 2020 Analysis and clinical application of new function of osteoprotegerin as anti-aging factor

2017 - 2020 Development of Simultaneous Regeneration Treatment for Tooth and Periodontal Tissue -Possibility of Tooth Germ Transplantation-

2016 - 2019 Applied research of periodontal disease therapeutics using osteogenic sugnal from osteoclasts

2015 - 2018 Clofibrate produce IL-1Ra and inhibit the experimental periodontitis

2015 - 2018 Attempt of bone regeneration by RANK peptide using alveolar bone resorption model

2015 - 2018 Functional roles of RhoT1 on repair of periodontal tissue

2014 - 2017 Effects of periodontal disease via serum amyloid A on aging on the mechanism of exacerbation of arteriosclerosis

2013 - 2016 Osteoclast-derived factors for inhibiting sclerostin expression is a bone coupling factor.

2012 - 2015 Production of the inflammatory periodontal disease model by the enhanced MAPK signaling

2012 - 2015 Regulations of bone metabolism by bovine- and neutrophil-derived lactoferrin

2012 - 2015 Analysis of bone remodeling mechanism between osteoblasts and osteoclasts for the alveolar bone regeneration

2013 - 2014 骨代謝共役を担うWntシグナルの解明

2011 - 2013 Analysis of the condition stress on the periodontal disease

2010 - 2011 The produced newly inflammatory periodontal disease model and evaluation of the therapeutic drug

2009 - 2011 Basic research on development of new treatment of alveolar bone regeneration

2009 - 2010 LPSシグナルを用いた口腔粘膜疾患モデルの開発

2008 - 2010 Microenvironment of stem cells in bone formation

2008 - 2010 Analysis of molecular mechanism of carbon nanotube regulating bone metabolism

2008 - 2009 Using bone resorption-related gene-modified mice, analysis of periodontitis model and development of drugs

2006 - 2008 Elucidation of the mechanism of enhancement of ectopic bone formation in osteopetrotic mice.

2006 - 2007 歯周組織再生を目指したCaチャンネル阻害剤の骨吸収と骨形成作用の解析

2006 - 2007 転写因子AP-1やNF-κBと協奏的に働く破骨細胞の分化因子のクローニング

2006 - 2007 The relationship between cell proliferation and RANKL-induced osteoclastogenesis

2004 - 2005 Ara-c(白血病薬剤)の骨代謝に及ぼす影響および骨再生についての研究

2004 - 2005 The roll of soluble interleukin-1 receptor type 2 for periodontal tissue

2003 - 2005 The working mechanism of bone resorption inhibitory protein induced by osteoclasts

2002 - 2003 The effects of the role of cytokine stimulated capsular polysaccharide Actinobacillus actinomycetemcomitans in human gingival fibroblast and monocyte.

Show all

Papers (66)：

中村圭吾, 石原裕一, 亀山敦史, 吉成伸夫, 宇田川信之, 小出雅則. スクレロスチン欠損はBMP-2誘導性異所性骨の石灰化を促進させる. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2023. 159回. 137-137
Keigo Nakamura, Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Mai Matsushita, Hisataka Yasuda, Yuichi Ishihara, Nobuo Yoshinari, Nobuyuki Udagawa. Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation. Journal of Periodontal Research. 2023. 58. 4. 769-779
Toru Hiraga, Kanji Horibe, Masanori Koide, Teruhito Yamashita, Yasuhiro Kobayashi. Sclerostin blockade promotes bone metastases of Wnt-responsive breast cancer cells. Cancer science. 2023. 114. 6. 2460-2470
Rina Iwamoto, Masanori Koide, Nobuyuki Udagawa, Yasuhiro Kobayashi. Positive and Negative Regulators of Sclerostin Expression. International journal of molecular sciences. 2022. 23. 9
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita-Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, et al. Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin-Deficient Mice. Journal of the American Heart Association. 2022. 11. 8. e025336

ｍore...

MISC (132)：

宇田川信之, 宇田川信之, 小出雅則, 中村美どり, 中村美どり, 田口明, 吉成伸夫. Crosstalk between periodontal disease and osteoporosis. 日本歯周病学会会誌(Web). 2024. 66. 1
小出雅則, 小林泰浩, 山下照仁, 宇田川信州, 中村圭吾, 吉成伸夫. スクレロスチン欠損はBMP-2誘導性異所性骨形成を効果的に促進する. Journal of Oral Biosciences Supplement. 2023. 2023. [P2-01]
小出雅則, 小林泰浩, 山下照仁, 宇田川信之, 宇田川信之. スクレロスチン欠損はBMP-2誘導性異所性骨形成を効果的に促進する. Journal of Oral Biosciences Supplement (Web). 2023. 2023
宇田川信之, 小出雅則, 中村美どり, 小林泰浩. Osteoclast differentiation and function. 生体の科学. 2023. 74. 6
小出雅則, 小林泰弘, 山下照仁, 保田尚孝, 宇田川信之, 宇田川信之. スクレロスチン欠損はBMP-2誘導性異所性骨形成を効果的に促進する. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2023. 41st

ｍore...

Work history (2)：

2019/12 - 現在 Matsumoto Dental University
2006 - 2019/11 Matsumoto Dental University

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page