Research keywords (6)：
phosphatase
, Kinase
, Cellular lifespan
, Protein dephosphorylation
, Intestinal epithelial cells
, Protein phosphorylation
Research theme for competitive and other funds (6)：
2020 - 2023 腸上皮細胞の寿命制御に関わる分子基盤の解明
2016 - 2019 腸上皮細胞の寿命を制御する分子基盤の解明
2014 - 2017 Molecular basis of the CD47-SIRP alpha signaling system in the regulation of physiological function
2014 - 2016 細胞間シグナル伝達システムCD47-SIRPα系による免疫制御機構の解析
2013 - 2015 チロシンホスファターゼShp-2を介した発がんスパイラル機構の解明
2011 - 2013 受容体型チロシンホスファターゼSAP-1による腸管免疫制御機構
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Papers (49)：
Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, et al. Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models. Frontiers in Immunology. 2023. 14
Satomi Komori, Yasuyuki Saito, Taichi Nishimura, Datu Respatika, Hiromi Endoh, Hiroki Yoshida, Risa Sugihara, Rie Iida-Norita, Tania Afroj, Tomoko Takai, et al. CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis. Proceedings of the National Academy of Sciences. 2023. 120. 33
Okamoto T, Murata Y, Hasegawa D, Yoshida M, Tanaka D, Ueda T, Hazama D, Oduori OS, Komori S, Takai T, et al. Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis. Cancer science. 2023
Yasuyuki Saito, Satomi Komori, Takenori Kotani, Yoji Murata, Takashi Matozaki. The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity. Cancers. 2022. 14. 8
Role of CD47 on the regulation of peripheral T cell survival by dendritic cells
(14th International Conference on Protein Phosphatase 2020)
Antibodies to SIRPα/SIRPβ as a potential tool for immunotherapy of bladder cancer
(14th International Conference on Protein Phosphatase 2020)
Blockade of the CD47-SIRPα interaction by SIRPα-binding macrocyclic peptides as a potential cancer immunotherapy
(14th International Conference on Protein Phosphatase 2020)
Roles of Shp2-Ras, Src family kinases, and mTOR signaling in intestinal epithelial homeostasis
(14th International Conference on Protein Phosphatase 2020)
SIRPα targeting as a potential therapy of Langerhans cell histiocytosis-
(2020)
