TAKEDA Yukari

タケダユカリ | TAKEDA Yukari

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://seiri2.med.lab.u-fukui.ac.jp/

Research field (2)： Clinical pharmacy , Physiology

Research keywords (1)： Physiology, signal transduction, cardiac myocyte, pancreatic beta cell, photoreceptor cells, systems biology (biosimulation)

Research theme for competitive and other funds (14)：

2023 - 2026 洞房結節ミトコンドリア-筋小胞体-細胞膜Ca連関異常が洞不全を誘発する機序の解明
2022 - 2025 Integrative study on homeostasis and pathophysiology of cardiac metabolism-automaticity coupling
2020 - 2023 Development of a Method for Mathematical Cell Modeling with Consideration of Individual Variability
2019 - 2022 糖尿病高血糖による洞房結節細胞Ca制御異常の解明
2019 - 2021 代謝イメージングによる心筋細胞における代謝ー興奮ー収縮連関の分子機構の解明

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Papers (11)：

Yukari Takeda, Kazuma Sato, Yukari Hosoki, Shuji Tachibanaki, Chieko Koike, Akira Amano. Mathematical analysis of phototransduction reaction parameters in rods and cones. Scientific Reports. 2022. 12. 1
Yukari Takeda, Satoshi Matsuoka. Impact of mitochondria on local calcium release in murine sinoatrial nodal cells. Journal of Molecular and Cellular Cardiology. 2022. 164. 42-50
Yukari Takeda. Theoretical Investigations into the Quantitative Mechanisms Underlying the Regulation of [cAMP](i), Membrane Excitability and [Ca2+](i) during GLP-1 Stimulation in Pancreatic beta Cells. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. 2016. 136. 3. 467-471
Yukari Takeda, Takao Shimayoshi, George G. Holz, Akinori Noma. Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic beta-cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016. 310. 5. C337-C347
Yukari Hosoki, Chieko Koike, Yukari Takeda, Akira Amano. Reproduction of light intensity-dependent activation of transducin in rod and cone by phototransduction model. Transactions of Japanese Society for Medical and Biological Engineering. 2014. 52. 3. 145-155

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MISC (13)：

Yukari Takeda, Kazuma Sato, Yukari Hosoki, Shuji Tachibanaki, Chieko Koike, Akira AMANO. Mathematical Analysis of Electrical Responses in Photoreceptor Cells Reveals Distinct Chemical Control of Visual Signal Transduction in Rods and Cones. 2021
Yukari Takeda, George G. Holz. Quantitative Modeling and Simulation Analysis of Membrane Excitability and [Ca2+]i Dynamics under the Control of GLP-1 in Pancreatic beta-Cells. DIABETES. 2017. 66. A583-A584
Saya Ito, Kazuma Sato, Yukiko Himeno, Yukari Takeda, Akira Amano. A Photoreceptor Model Considering Regulation of Ionic Homeostasis. BIOPHYSICAL JOURNAL. 2017. 112. 3. 531A-531A
Kazuma Sato, Saya Ito, Yukari Hosoki, Yukari Takeda, Chieko Koike, Akira Amano. Simulation Analysis of Phototransduction Systems in Rods and Cones. BIOPHYSICAL JOURNAL. 2017. 112. 3. 531A-531A
竹田有加里, 嶋吉隆夫, HOLZ George. 膵β細胞におけるGLP-1受容体刺激による膜興奮性及びカルシウム動態制御機構の理論研究. 糖尿病(Web). 2017. 60. Suppl. S.466(J-STAGE)

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Books (3)：

Lectures and oral presentations (66)：

Electrophysiological and Ca2+ handling properties of atrial myocytes derived from a mouse model of myocardial steatosis
(APPW2025 (第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会) 2025)
Augmented transient outward K+ current and sarcoplasmic reticulum Ca2+ overload are associated with atrial fibrillation susceptibility in a mouse model of myocardial steatosis
(2024)
High glucose induced irregular rhythm of mouse sinoatrial node
(2024)
Impairment in pacemaker function of sinoatrial nodal cells in a mouse model of myocardial steatosis
(The 10th Federation of the Asian and Oceanian Physiological Societies Congress 2023)
Irregular pacemaking rhythm in mice with accumulation of lipid droplets in cardiomyocyte
(2023)

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Works (3)：

第3回e-Heartシンポジウム数理生体機能モデルサマースクールにて、基礎研究や臨床への実用化にむけた講習会にて、e-Heartの基礎研究や臨床への実用化にむけた講習会
2015 - 2015
第2回e-Heartシンポジウムバイオシミュレーション講習会にて、基礎研究や臨床への実用化にむけた講習会
2015 - 2015
第29回日本不整脈学会学術大会/第31回日本心電学会学術集会合同学術大会 E-heart説明会
2014 - 2014

Education (2)：

- 2007 University of Nevada Graduate School of Medicine Physiology and Cell Biology Cellular and Molecular Pharmacology & Physiology
- 2002 University of Nevada Reno Biology

Professional career (1)：

Work history (7)：

2017/08 - 現在 University of Fukui Department of Integrative & Systems Physiology, Faculty of Medical Sciences Assistant Professor
2016/04 - 現在 Visiting researcher at kansai Electric Power Medical Research Institute
2013/04 - 2017/07 Ritsumeikan University College of Life Sciences, Department of Bioinformatics Assistant Professor
2012/04/01 - 2013/03/31 Ritsumeikan University・R-GIRO Postdoctoral Fellow
2010/04/01 - 2012/03/31 Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Assistant Professor

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Committee career (4)：

Awards (4)：

2014 - Japan Association for Diabetes and Care JADEC International Research Promotion Award
2007 - The 21st International Symposium on Neurogastroenterology and Motility Travel Award
2006 - University of Nevada, Reno Outstanding International Graduate Students Award, University of Nevada, Reno
2005 - University of Nevada, Reno Outstanding International Graduate Students Award, University of Nevada, Reno

Association Membership(s) (6)：

日本生理学会 , American Diabetes Association , Biophysical Society , 日本糖尿病学会 , The Japan Diabetes Society , Japan Association for Diabetes and Care

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