Rchr
J-GLOBAL ID：201301059908260266   Update date: Oct. 03, 2024

Sengoku Toru

センゴク トオル | Sengoku Toru
Affiliation and department：
Yokohama City University School of Medicine Medical Course Biochemistry

About Yokohama City University School of Medicine Medical Course Biochemistry


Job title： Associate Professor
Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/60576312.ja.html
Research field  (1)： Structural biochemistry
Research keywords  (6)： Structural Biology ,  Epigenetics ,  Transcription ,  環状ペプチド ,  RNA ,  Drug Design
Research theme for competitive and other funds  (11)：
  • 2020 - 2025 Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products
  • 2021 - 2024 Structural elucidation of the multi-subunit interactions that establish the transcriptional unity mechanism
  • 2021 - 2024 Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions
  • 2021 - 2024 トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明
  • 2020 - 2022 Mechanisms that establish, maintain, and dysregulate histone methylation states
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Papers (38)：
  • Sumika Inoue, Dinh Thanh Nguyen, Keisuke Hamada, Rika Okuma, Chikako Okada, Masahiro Okada, Ikuro Abe, Toru Sengoku, Yuki Goto, Hiroaki Suga. De Novo Discovery of Pseudo-Natural Prenylated Macrocyclic Peptide Ligands. Angewandte Chemie International Edition. 2024
  • Tomomi Sumida, Satoshi Hiraoka, Keiko Usui, Akihiro Ishiwata, Toru Sengoku, Keith A. Stubbs, Katsunori Tanaka, Shigeru Deguchi, Shinya Fushinobu, Takuro Nunoura. Genetic and functional diversity of β-N-acetylgalactosamine-targeting glycosidases expanded by deep-sea metagenome analysis. Nature Communications. 2024. 15. 1
  • Alexander A Vinogradov, Yue Zhang, Keisuke Hamada, Shunsuke Kobayashi, Kazuhiro Ogata, Toru Sengoku, Yuki Goto, Hiroaki Suga. A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. Journal of the American Chemical Society. 2024. 146. 12. 8058-8070
  • Shuhei Onishi, Kotone Uchiyama, Ko Sato, Chikako Okada, Shunsuke Kobayashi, Keisuke Hamada, Tomohiro Nishizawa, Osamu Nureki, Kazuhiro Ogata, Toru Sengoku. Structure of the human Bre1 complex bound to the nucleosome. Nature Communications. 2024. 15. 1
  • Yuchen Zhang, Keisuke Hamada, Masayuki Satake, Toru Sengoku, Yuki Goto, Hiroaki Suga. Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases. Journal of the American Chemical Society. 2023. 145. 44. 23893-23898
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MISC (12)：
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Works (29)：
  • Nrf2-MafG heterodimer bound with CsMBE1
    Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Okada, C., Baba, S., Ohta, T., Motohashi, H., Yamamoto, M., Ogata, K.
  • Nrf2-MafG heterodimer bound with CsMBE2
    Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Okada, C., Baba, S., Ohta, T., Motohashi, H., Yamamoto, M., Ogata, K.
  • Nrf2 (A510Y)-MafG heterodimer bound with CsMBE2
    Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Okada, C., Baba, S., Ohta, T., Motohashi, H., Yamamoto, M., Ogata, K.
  • Crystal structure of TNIK-thiopeptide TP1 complex
    Hamada, K., Vinogradov, A.A., Zhang, Y., Chang, J.S., Nishimura, H., Goto, Y., Onaka, H., Suga, H., Ogata, K., Sengoku, T.
  • Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex
    Hamada, K., Vinogradov, A.A., Zhang, Y., Chang, J.S., Nishimura, H., Goto, Y., Onaka, H., Suga, H., Ogata, K., Sengoku, T.
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Professional career (1)：
  • 理学博士 (東京大学)
Work history (1)：
  • 2011 - RIKEN
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