Saigusa Daisuke

サイグサダイスケ | Saigusa Daisuke

Affiliation and department：
Job title： Associate Professor
Other affiliations (1)：

Tohoku University Tohoku Medical Megabank Organization Visiting Associate Professor

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (7)： Biomarker , Chromatography , Mass Spectrometry Imaging , Lipidomics , Analytical Chemistry , Mass Spectrometry , Metabolomics

Research theme for competitive and other funds (21)：

2024 - 2027 尿毒素による細胞内代謝失調を標的とした高齢者の慢性腎臓病合併症の治療開発
2023 - 2027 尿毒素による細胞内代謝失調を標的とした高齢者の慢性腎臓病合併症の治療開発
2023 - 2026 Elucidation of spatio-temporal regulation mechanisms of brain pharmacokinetics by blood-brain, arachnoid and cerebrospinal fluid barriers
2023 - 2026 投影型MSイメージング法による脂質ラフト含有スフィンゴ脂質の可視化技術開発
2021 - 2024 前眼部組織間のトランスオミクス解析による包括的な眼圧上昇機序の解明

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Papers (141)：

Federico Torta, Nils Hoffmann, Bo Burla, Irina Alecu, Makoto Arita, Takeshi Bamba, Steffany A. L. Bennett, Justine Bertrand-Michel, Britta Brügger, Mónica P. Cala, et al. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nature Communications. 2024. 15. 1
Akiyo Sekimoto, Yoko Takaso, Haruka Saruyama, Masataka Ookawa, Mari Yamamoto, Takafumi Toyohara, Daisuke Saigusa, Tomoko Fukuuchi, Mayu Otsuka, Yui Fushiki, et al. Impacts of low birthweight on kidney development and intergenerational growth of the offspring. iScience. 2024. 111159-111159
Akira Uruno, Shiori Kadoguchi-Igarashi, Ritsumi Saito, Shohei Koiso, Daisuke Saigusa, Ching-Tung Chu, Takafumi Suzuki, Takashi Saito, Takaomi C Saido, Antonio Cuadrado, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice. Journal of biochemistry. 2024
Taku Nakai, Daisuke Saigusa, Koichiro Kato, Tomoko Fukuuchi, Seizo Koshiba, Masayuki Yamamoto, Norio Suzuki. The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction. Life Sciences. 2024. 346. 122641-122641
Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, et al. Dietary habits and plasma lipid concentrations in a general Japanese population. Metabolomics : Official journal of the Metabolomic Society. 2024. 20. 2. 34-34

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MISC (163)：

大橋智輝, 中井琢, 福内友子, 山岡法子, 小柴生造, 山本雅之, 鈴木教郎, 三枝大輔, 三枝大輔. Surrogate marker discovery for anti-doping test using the vadadustat treatment mice. 日本薬学会年会要旨集(Web). 2024. 144th
内田新菜, 中井琢, 福内友子, 山岡法子, 小柴生造, 山本雅之, 鈴木教郎, 三枝大輔, 三枝大輔. Metabolic profiling of plasma and urine for the daprodustat treatment mice by GC-MS/MS. 日本薬学会年会要旨集(Web). 2024. 144th
西原詩織, 佐藤孝太, 藤岡周, 横山悠, 福内友子, 山岡法子, 中澤徹, 三枝大輔, 三枝大輔. Biomarker discovery of glaucoma by the lipidomic profiling of extracellular vesicles in aquas humor. 日本薬学会年会要旨集(Web). 2024. 144th
頓宮慶泰, 頓宮慶泰, 豊原敬文, 藤田理彩子, 藤田理彩子, 三枝大輔, 及川善嗣, 松橋徹郎, 沼倉周彦, 兪志前, et al. MA-5 a novel therapeutic approach, for Gaucher disease, via mitochondrial dysfunction/NLRP3 inflammasome axis. 日本小児科学会雑誌. 2023. 127. 2
松田史生, 松田史生, 三枝大輔, 三枝大輔, 西岡孝明. Practical Guide of MassBank Vol. 2. Journal of the Mass Spectrometry Society of Japan. 2023. 71. 1

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Books (5)：

メタボロミクス実践ガイド : サンプル調製からデータ解析まで、あなたに合った実験デザインと達人テクニック
羊土社 2021 ISBN:9784758122511
Uremic toxins and guanidino compounds
2017
Kidney Science
2016
Bioactive Lipid Mediators
Springer Nature 2015
Bioactive Lipid Mediators
2013

Lectures and oral presentations (28)：

Development of ultra-sensitive detection of lysophospholipids by mass spectrometry
(The 72nd Annual Conference on Mass Spectrometry, Japan 2024)
生体内メタボローム解析技術開発と疾患バイオマーカー探索研究への応用
(第47回日本医用マススペクトル学会年会 2022)
Lipidomic Profiling in the Large-Scale Cohort for Biomarker Discovery and the Importance of Separation Science
(Lipidomics, Gordon Research Conference 2022)
Evaluation for quantified values of lipidomic profiling in a large-scale cohort
(iSLS10 2022)
Addressing accuracy of reference values in a large-scale cohort by MS-based metabolomics
(Virtual Podium Asia Pacific (VPAP) 2021)

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Education (2)：

2006 - 2009 Tohoku University Graduate School of Pharmaceutical Sciences
2002 - 2006 Hoshi University

Professional career (1)：

Ph.D. (Tohoku University)

Work history (8)：

2021/10 - 現在 Tohoku University Tohoku Medical Megabank Organization Associate Professor
2021/10 - 現在 Faculty of Pharma-Scienses Laboratory of Biomedical and Analytical Sciences Associate Professor
2022/09 - 2023/10 Turin University Visiting Professor
2020/10 - 2021/09 University of Turin Visiting Professor
2015/08 - 2021/09 Tohoku University Tohoku Medical Megabank Organization / Graduate School of Medicine Senior Assistant Professor

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Committee career (2)：

2021/06 - 現在 The Mass Spectrometry Society of Japan Director
2017/09 - 現在 Japanese Society for Biomedical Mass Spectrometry Councilor

Awards (5)：

2024/06 - The Mass Spectrometry Society of Japan Research Award
2022/09 - Japanese Society for Biomedical Mass Spectrometry Encouragement Award
2014/05 - The Mass Spectrometry Society of Japan Best Presentation Award
2011/10 - Research Group of Ganidino Compounds Young Encouragement Award
2011/09 - Japanese Society for Biomedical Mass Spectrometry Poster Award

Association Membership(s) (11)：

Lipidomics-Standards-Initiative , Japan Society of Clinical Chemistry , Japan Human Proteome Organization , Metabolomics Society , The Mass Spectrometry Society of Japan , Japanese Society for Biomedical Mass Spectrometry , 日本薬学会 , Japanese Society for Pharmaceutical Palliative Care and Sciences , The Japanese Biochemical Society , American Society of Mass Spectrometry , Mass Spectrometry Imaging Society

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