Iwasaki Tetsushi

イワサキテツシ | Iwasaki Tetsushi

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Functional biochemistry , Cell biology

Research theme for competitive and other funds (10)：

2021 - 2024 Establishment of a basis for the development of anti-aging medicine using spontaneous senescent cells
2022 - 2023 がん細胞から生じる老化細胞の形成機構とその除去方法の確立
2020 - 2023 Basic research for the development of novel anticancer drugs targeting senescent cells induced by cancer treatment
2020 - 2022 ミネラルナノ粒子による高度細胞増殖技術の開発とそのメカニズム解析
2015 - 2018 多次元フローサイトメトリー法によるシグナル分子修飾の解析

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Papers (45)：

Taiichi Osumi, Taiki Nagano, Tetsushi Iwasaki, Jotaro Nakanishi, Kazuyuki Miyazawa, Shinji Kamada. Lysine-specific demethylase 1 (LSD1) suppresses cellular senescence by riboflavin uptake-dependent demethylation activity. Scientific Reports. 2025. 15. 1
Ryoko Katasho, Taiki Nagano, Tetsushi Iwasaki, Shinji Kamada. Nectin-4 regulates cellular senescence-associated enlargement of cell size. Scientific Reports. 2023. 13. 1
Keitaro Nakagawa, Taiki Nagano, Ryoko Katasho, Tetsushi Iwasaki, Shinji Kamada. Integrin β1 transduces the signal forLY6D-induced macropinocytosis and mediates senescence-inducing stress-evoked vacuole formation viaFAK. FEBS Letters. 2022. 596. 21. 2768-2780
Yuki Yoshikawa, Keisuke Yuzu, Naoki Yamamoto, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Tetsushi Iwasaki, Masatomo So, Yuji Goto, Atsuo Tamura, et al. Pathway Dependence of the Formation and Development of Prefibrillar Aggregates in Insulin B Chain. Molecules. 2022. 27. 13. 3964-3964
Watson P Folk, Alpana Kumari, Tetsushi Iwasaki, Erica K Cassimere, Slovénie Pyndiah, Elizabeth Martin, Kelly Homlar, Daitoku Sakamuro. New Synthetic Lethality Re-Sensitizing Platinum-Refractory Cancer Cells to Cisplatin In Vitro: The Rationale to Co-Use PARP and ATM Inhibitors. International journal of molecular sciences. 2021. 22. 24

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MISC (28)：

Alpana Kumari, Tetsushi Iwasaki, Walson P. Folk, Amy L. Abdulovic-Cui, Slovenie Pyndiah, George C. Prendergast, John M. Sedivy, Daitoku Sakamuro. c-MYC preserves genomic integrity during DNA replication: a paradigm shift of c-MYC. MOLECULAR CANCER RESEARCH. 2016. 14
T. Fukumoto, T. Iwasaki, T. Okada, T. Hashimoto, Y. Moon, M. Sakaguchi, Y. Fukami, C. Nishigori, M. Oka. High expression of Mcl-1 mediated by MEK-ERK1/2-STAT3 signaling pathway protects melanocytes and melanoma cells against ultraviolet B-induced apoptosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015. 135. S107-S107
Alexander A Tokmakov, Vasily E Stefanov, Tetsushi Iwasaki, Ken-Ichi Sato, Yasuo Fukami. Calcium signaling and meiotic exit at fertilization in Xenopus egg. International journal of molecular sciences. 2014. 15. 10. 18659-76
M. Oka, M. Sakaguchi, T. Iwasaki, Y. Fukami, C. Nishigori. Ser727 phosphorylation in STAT3 plays a crucial role in cell survival and nuclear translocation of STAT3 in human melanocytes and melanoma cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012. 132. S24-S24
M. Sakaguchi, M. Oka, T. Iwasaki, Y. Fukami, C. Nishigori. Ser727 phosphorylation in STAT3 plays a crucial role in nuclear translocation of STAT3 and growth in human melanoma cells and melanocytes. PIGMENT CELL & MELANOMA RESEARCH. 2011. 24. 4. 791-792

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Lectures and oral presentations (91)：

Senescence-related gene EPN3 induces DNA damage via extracellular vesicles
(2024)
リジン特異的脱メチル化酵素LSD1の活性化を介した細胞老化抑制機構の解析
(第47回日本分子生物学会2024 2024)
TPAによる転移性メラノーマ増殖抑制におけるTC-TP/PTPN2及びSH-PTP2/PTPN11の機能解析
(第47回日本分子生物学会 2024 2024)
細胞老化抑制機構における脱メチル化酵素JMJD2Cの機能解析
(第47回日本分子生物学会 2024 2024)
自発老化細胞の形成機構とSASPを介した周辺がん細胞への影響
(第47回日本分子生物学会 2024 2024)

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Professional career (2)：

Awards (1)：

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