Takahashi Harumi

タカハシハルミ | Takahashi Harumi

Affiliation and department：

Research field (1)： Metabolism and endocrinology

Research theme for competitive and other funds (7)：

2019 - 2022 グルタミン酸シグナルによるインスリン開口分泌制御機構の解明
2019 - 2022 The role of Epac2/Rap1 signaling in the three-dimensional construction of pancreatic islets
2016 - 2019 The physiological and pathophysiological roles of glutamate signaling in pancreatic beta-cell
2016 - 2019 膵β細胞保護におけるEpac2A/Rap1シグナルの役割とその機序の解明
2015 - 2018 The role of Noc2 in incretin secretion

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Papers (44)：

権映月, 菅原健二, 高橋晴美, 横井伯英, 大林健人, 岩崎有作, 清野進, 小川渉. インクレチン分泌に対するimegliminの効果(The effects of imeglimin on incretin secretion). 糖尿病. 2023. 66. Suppl.1. S-177
Quan Yingyue, Kenji Sugawara, Harumi Takahashi, Norihide Yokoi, Kento Ohbayashi, Yusaku Iwasaki, Susumu Seino, Wataru Ogawa. Stimulatory effect of imeglimin on incretin secretion. Journal of diabetes investigation. 2023
Mai Yoshida, Norihide Yokoi, Harumi Takahashi, Naoya Hatano, Tomohide Hayami, Wataru Ogawa, Susumu Seino. O-GlcNAcylation of myocyte-specific enhancer factor 2D negatively regulates insulin secretion from pancreatic β-cells. Biochemical and Biophysical Research Communications. 2022. 605. 90-96
Naoya Murao, Norihide Yokoi, Harumi Takahashi, Tomohide Hayami, Yasuhiro Minami, Susumu Seino. Increased glycolysis affects β-cell function and identity in aging and diabetes. Molecular Metabolism. 2022. 55. 101414-101414
Guirong Han, Harumi Takahashi, Naoya Murao, Ghupurjan Gheni, Norihide Yokoi, Yoshiyuki Hamamoto, Shun-Ichiro Asahara, Yutaka Seino, Yoshiaki Kido, Susumu Seino. Glutamate is an essential mediator in glutamine-amplified insulin secretion. Journal of diabetes investigation. 2021. 12. 6. 920-930

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MISC (15)：

高橋晴美, オドゥオリ・オケチ, 清野進. 【糖尿病治療・研究の最前線2021】基礎研究インスリン分泌機構糖尿病の膵β細胞におけるGタンパク質シグナル変換の意義. 医学のあゆみ. 2021. 276. 5. 364-370
N. Yokoi, M. Hashim, G. Gheni, H. Takahashi, S. Seino. Formation of peudoislets induces incretin responsiveness in incretin-unresponsive clonal beta cells: possible role of an amino acid transporter. DIABETOLOGIA. 2017. 60. S189-S189
Okechi Oduori, Kenji Sugawara, Sakura Yoshida, Harumi Takahashi, Norihide Yokoi, Morio Nakayama, Susumu Seino. Trans-S-1-propenyl-l-cysteine sulfoxide from Allium cepa (onions) has appreciable antidiabetic potential in streptozotocin-induced diabetic mice. DIABETES RESEARCH AND CLINICAL PRACTICE. 2016. 120. S61-S62
M. Hashim, N. Yokoi, G. Gheni, R. Hoshikawa, H. Takahashi, S. Seino. Mechanisms of the induction of incretin/cAMP responsiveness in insulin secretion: study by pseudoislets. DIABETOLOGIA. 2016. 59. S222-S222
O. S. Oduori, K. Minami, N. Yokoi, Y. Maejima, H. Takahashi, P. L. Herrera, K. Shimomura, S. Seino. Deletion of beta cell specific K-ATP channels causes severe glucose intolerance with impaired insulin secretion and enhanced incretin secretion. DIABETOLOGIA. 2016. 59. S85-S85

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Lectures and oral presentations (94)：

新規Epac2アイソフォームの膵β細胞機能における役割
(第63回日本糖尿病学会年次学術集会 2020)
Novel Epac2 isoforms and their roles in pancreatic β-cell functions
(2020)
Role of Noc2 in incretin exocytosis
(Asia Islet Biology and Incretin Symposium 2019 2019)
膵β細胞に発現する新たなEpac2アイソフォームとその特異的な役割
(第62回日本糖尿病学会年次学術集会 2019)
新規インスリン分泌促進薬シード化合物の同定とその作用機序の解明
(糖尿病 2019)

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Education (2)：

Professional career (2)：

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