Research field (3)：
Genomics
, Tumor biology
, Respiratory surgery
Research keywords (7)：
Mesothelioma
, Lung Cancer
, Thoracic Surgery
, 悪性胸膜中皮腫
, 肺癌
, 呼吸器外科
, 胸部外科
Research theme for competitive and other funds (16)：
2023 - 2027 Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancer
2023 - 2027 Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy
2022 - 2027 耐性化機序に基づいたHER2陽性乳癌に対する治療戦略の開発
2023 - 2026 メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明
2023 - 2026 Elucidation of Tumor Microenvironment Network Regulated by Fibrinolysis Inhibitory Factor and Its Therapeutic Application
2022 - 2026 マトリセルラータンパク質阻害によるがん微小環境の破壊と抗腫瘍効果の検討
2022 - 2025 Clarification of the mechanism for endogenous retrovirus to get involved in the antitumor immunity response
2020 - 2023 Novel therapeutic approaches for lung cancer by using iPS cell-derived organoids
2018 - 2021 Development of innovative therapeutic antibodies targeting the inflammatory tumor microenvironment in refractory thoracic tumors
2018 - 2021 Novel therapeutic strategy focused on EGFR-binding protein LRIG1 for EGFR-mutant lung cancer
2017 - 2020 Mechanistic analysis of an unidentified downstream signals of S100A8/A9 receptors that play a crucial role in acquisition of metastatic force and formation of cancer microenvironment.
2016 - 2019 Development of new therapeutic strategy based on gene expression and mutation profiles in EGFR mutant lung cancer
2016 - 2017 EGFR-TKI resistance and epigenetic alterations in lung cancer treatment
2014 - 2017 Identification of novel targets in the treatment of lung cancer
2013 - 2016 Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
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Papers (162)：
Kazuma Iwata, Ken Suzawa, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka. Utility of neutrophil-to-lymphocyte ratio as an indicator of tumor immune status in non-small cell lung cancer. Japanese journal of clinical oncology. 2024
Shin Tanaka, Kento Fujii, Megumi Ishihara, Haruki Choshi, Kei Matsubara, Kohei Hashimoto, Shuji Okahara, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, et al. Postoperative Complications in Living Donors for Lung Transplantation. Transplantation direct. 2024. 10. 5. e1617
Yusuke Otani, Haruyoshi Katayama, Yidan Zhu, Rongsheng Huang, Takafumi Shigehira, Kazuhiko Shien, Ken Suzawa, Hiromasa Yamamoto, Tadahiko Shien, Shinichi Toyooka, et al. Adrenergic microenvironment driven by cancer-associated Schwann cells contributes to chemoresistance in patients with lung cancer. Cancer Science. 2024
Mikio Okazaki, Ken Suzawa, Kazuhiko Shien, Kohei Hashimoto, Shin Tanaka, Kentaroh Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Shinichi Toyooka. Effective division of the intersegmental plane using a robotic stapler in robotic pulmonary segmentectomy. Surgery today. 2024
Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, et al. Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery. Surgery today. 2024
2013/04 - 2014/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
2010/04 - 2013/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
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Association Membership(s) (6)：
JAPAN SOCIETY OF CLINICAL ONCOLOGY
, THE JAPAN LUNG CANCER SOCIETY
, THE JAPANESE ASSOCIATION FOR CHEST SURGERY
, THE JAPANESE ASSOCIATION FOR THORACIC SURGERY
, JAPAN SURGICAL SOCIETY
, 日本癌学会
