Rchr
J-GLOBAL ID：201401000236751978   Update date: Dec. 11, 2024

Kitakaze Keisuke

キタカゼ ケイスケ | Kitakaze Keisuke
Affiliation and department：
Kawasaki Medical School Department of Pharmacology

About Kawasaki Medical School Department of Pharmacology


Job title： Assistant Professor
Homepage URL  (1)： https://kms-pharmacol.wixsite.com/website
Research field  (6)： Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Nutrition and health science ,  Psychiatry ,  Respiratory medicine ,  Internal medicine - General
Research keywords  (9)： lipid mediator ,  脂質代謝 ,  diabetes ,  endoplasmic reticulum stress ,  Comprehensive Brain Science Network ,  neurodegenerative disease ,  glycolipid ,  glycan ,  lysosomal storage disease
Research theme for competitive and other funds  (17)：
  • 2023 - 2026 Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  • 2024 - 2025 2023年度 研究奨励金
  • 2024 - 2025 令和6年度 研究活動費助成事業
  • 2023 - 2025 Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
  • 2022 - 2025 Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
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Papers (20)：
  • Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Rena Matsui, Daisuke Koga, Ryo Miyashima, Hironobu Ishimaru, KazuhitoTsuboi. GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression. Biochimica et Biophysica Acta - Molecular Cell Research. 2024. 1871. 7. 119798
  • Hironobu Ishimaru, Kenta Nakamoto, Mariko Yamane, Takenobu Yamamoto, Keisuke, Kitakaze, Yasuhiro Takenouchi, Kazuhito Tsuboi, Yasuo Okamoto, Yumi Aoyama. Sweat protects against contact hypersensitivity: Transient sweat suppression compromises skin barrier function in mice. Journal of Investigative Dermatology. 2024. 144. 10. 2211-2220.e6
  • Keisuke Kitakaze, Hanif Ali, Raiki Kimoto, Yasuhiro Takenouchi, Hironobu Ishimaru, Atsushi Yamashita, Natsuo Ueda, Tamotsu Tanaka, Yasuo Okamoto, Kazuhito Tsuboi. GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. Communications Biology. 2023. 6. 524
  • Kitakaze K, Tsuboi K. A simple enzyme assay for glycerophosphodiesterase GDE4 and GDE7 using fluorescent substrate. Journal of Japanese Biochemical Society. 2022. 94. 6. 923-927
  • Shuichiro Okamoto, Kei Miyano, Keisuke Kitakaze, Hitomi Kato, Akira Yamauchi, Mizuho Kajikawa, Momoe Itsumi, Chikage Kawai, Futoshi Kuribayashi. Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling-independent manner. Biochemical and Biophysical Research Communications. 2021. 587. 78-84
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MISC (20)：
  • 【プレスリリース】オーファンGタンパク質共役型受容体GPR176は線維化を促進する. 2024
  • Chika Shinoda, Keisuke Kitakaze, Yuya Sasai, So-ichiro Nishioka, Isao Kobayashi, Megumi Sumitani, Ken-ichiro Tatematsu, Tetsuya Iizuka, Akira Harazono, Ai Mitani, et al. N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates symptoms in a Japanese macaque with mucopolysaccharidosis I. Research Square. 2024
  • 【プレスリリース】環状リン脂質メディエーターを小胞体で産生する酵素を発見 ~乳がんや肥満の治療標的分子として期待~. 2023
  • Keisuke Kitakaze, Hanif Ali, Raiki Kimoto, Yasuhiro Takenouchi, Hironobu Ishimaru, Atsushi Yamashita, Natsuo Ueda, Tamotsu Tanaka, Yasuo Okamoto, Kazuhito Tsuboi. Cyclic phosphatidic acid is produced by GDE7 in the ER lumen as a lysophospholipid mediator. Research Square. 2022
  • Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Kazuhito Tsuboi. The role of sphingosine 1-phosphate type 2 receptor on IL-4/IL-13-stimulated STAT6 phosphorylation in phorbol12-myristate13-acetate-treated THP-1 cells. The FASEB Journal. 2021. 35. S1
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Lectures and oral presentations  (128)：
  • 新規蛍光基質を用いた酸性セラミダーゼのリアルタイム活性測定法
    (The 146th Kinki Branch Meeting of the Japanase Pharmacological Society 2024)
  • Investigation of the role of senescent cells in pulmonary fibrosis using p16-conditional knockout mice
    (The 97th Annual Meeting of the Japanese Biochemical Society 2024)
  • GPR176/Gz signaling is involved in fibroblast activation via the TGFβ1/Smads/αSMA pathway
    (The 97th Annual Meeting of the Japanese Biochemical Society 2024)
  • Analysis for the specificity of fluorescent substrates for acid ceramidase
    (The 97th Annual Meeting of the Japanese Biochemical Society 2024)
  • Functional analyses of glycerophosphodiesterase GDE4 in a prostate cancer cell line
    (The 97th Annual Meeting of the Japanese Biochemical Society 2024)
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Professional career (1)：
  • Doctor of Pharmaceutical Science (Tokushima University)
Work history (2)：
  • 2019/01 - 現在 Kawasaki Medical School Department of Pharmacology Assistant professor
  • 2016/04 - 2018/12 Institute of Advanced Medical Sciences, Tokushima University Division of Molecular Biology Project Researcher
Committee career (1)：
  • 2024/04 - 現在 THE JAPANESE PHARMACOLOGICAL SOCIETY a member of a scientific council
Awards (14)：
  • 2022/07 - 最優秀発表賞
  • 2021/03 - Young Investigator Award (YIA)
  • 2020/01 - LEGEND Travel Award 2020
  • 2019/05 - 優秀研究発表賞
  • 2018/11 - ポスター賞
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Association Membership(s) (3)：
THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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