Ono Yusuke

オノユウスケ | Ono Yusuke

Affiliation and department：
Job title：部門長
Other affiliations (2)：

Homepage URL (1)： https://www.higashi-tokushukai.or.jp/inst_biomed_res/

Research field (4)： Tumor diagnostics and therapeutics , Genomics , Tumor biology , Applied biochemistry

Research keywords (5)：リキッドバイオプシー , 膵臓 , バイオインフォマティクス , バイオマーカー , がん

Research theme for competitive and other funds (18)：

2024 - 2027 膵癌分子サブタイプに関わるncRNAの探索と分子診断および創薬への応用
2024 - 2027 Early Diagnosis of Pancreatic Cancer Based on the Mechanism of Development of Precancerous Lesions and the Emergence of Invasive Buds during Carcinogenesis
2024 - 膵癌ドライバー変異に連動する遊離 RNA 検出系を用いた早期診断
2023 - 膵癌の超早期診断を目指すマルチ核酸リキッドバイオプシー: ドライバー変異が引き起こす転写リプログラミングをバイオマーカーとした統合診断系の創出
2023 - 膵管内乳頭粘液性腫瘍(IPMN)関連膵癌の超早期診断を目指して:KRAS-GNAS遺伝子変異特異的な膵組織発現プロファイルの検出を目指したリキッドバイオプシー

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Papers (54)：

Shuji Suzuki, Yuko Omori, Yusuke Ono, Katsuya Hirose, Taito Itoh, Hidenori Karasaki, Mitsugi Shimoda, Yuichi Nagakawa, Ryota Higuchi, Itaru Endo, et al. Three Molecular Developmental Pathways of Remnant Pancreatic Cancer after Resection. Annals of Surgery. 2024
Takuya Maeda, Teruki Yanagi, Shinya Kitamura, Hiroshi Nishihara, Yusuke Ono, Yusuke Mizukami, Shinya Tanaka, Hideyuki Ujiie. A familial case of extramammary Paget disease: Analysis of whole-exome sequencing. EJC Skin Cancer. 2024
Kenji Takahashi, Tatsutoshi Inuzuka, Yuta Shimizu, Kazuki Sawamoto, Kenzui Taniue, Yusuke Ono, Fumi Asai, Kazuya Koyama, Hiroki Sato, Hidemasa Kawabata, et al. Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA. Pancreas. 2024
Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, et al. Clonal analysis of metachronous double biliary tract cancers. The Journal of Pathology. 2024
Hiroyuki Hato, Atsushi Kaneko, Chiho Maeda, Ken-ichiro Sakata, Yusuke Ono, Yusuke Mizukami, Toru Kono, Yoshimasa Kitagawa. Comparison between hangeshashinto and dexamethasone for IL-1α and β-defensin 1 production by human oral keratinocytes. Journal of Oral Biosciences. 2024

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MISC (9)：

Yusuke Ono, Kenji Takahashi, Yusuke Mizukami. KRAS Mutation in IPMN-Related Pancreatic Cancer. 2023. 44. 7. 665-671
Kenji Takahashi, Yohei Takeda, Yusuke Ono, Hajime Isomoto, Yusuke Mizukami. Current status of molecular diagnostic approaches using liquid biopsy. Journal of Gastroenterology. 2023
小野裕介, 谷上賢瑞, 水上裕輔. デジタル PCR を用いたがん遺伝子解析の研究. 応用物理学会有機分子・バイオエレクトロニクス分科会会誌. 2022. 33. 4. 223-232
高橋賢治, 大森優子, 小野裕介, 古川徹, 水上裕輔. 【Liquid biopsyは膵癌の診断・治療をどう変えるか?】IPMNの悪性度評価とliquid biopsy. 胆と膵. 2022. 43. 1. 33-42
Kenji Takahashi, Kenzui Taniue, Yusuke Ono, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura. Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer. Front Mol Biosci. 2021

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Patents (1)：

Books (1)：

Lectures and oral presentations (16)：

High-sensitive liquid biopsy using pancreatic juice/duodenal fluid containing tumor-derived DNA to capture genetic mutations by molecular barcode sequencing
(31st UEG week 2023; Abstract Session "New insights into pancreatic diseases: From inflammation to cancer" 2023)
Liquid biopsy for detection of pancreatic neoplasms-derived gene mutations i n digestive fluids
(2022)
High-sensitive mutation detection in liquid biopsy with duodenal fluid captures genetic mutations associated with pancreatic carcinogenesis
(AACR Special Conference; Pancreatic Cancer 2022; Plenary Session 5 "Prevention & Interception" 2022)
Molecular barcode sequencing using duodenal fluid for profiling genomic alterations in pancreatic neoplasms
(Joint congress of the 26th meeting of international association of pancreatology and the 53rd annual meeting of japan pancreas society: Panel Discussion: Quest for early diagnosis of pancreatic cancer 2022)
分子バーコードを用いた十二指腸液由来核酸の変異解析〜より高濃度の変異検出をターゲットとした膵癌リキッドバイオプシー〜
(第6回 Liquid Biopsy研究会 2022)

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Professional career (3)：

Work history (9)：

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Awards (4)：

Association Membership(s) (3)：

日本遺伝子診療学会 , THE JAPAN SOCIETY OF HUMAN GENETICS , THE JAPANESE CANCER ASSOCIATION

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