Rchr
J-GLOBAL ID：201401001576977454
Update date: Apr. 27, 2024
Kawahara Masahiro
Kawahara Masahiro
Affiliation and department：
Research field (1)：
Hematology and oncology
Research theme for competitive and other funds (2)：
- 2019 - 2022 NUDT15遺伝子型に基づき個人に最適化された安全かつ有効的なチオプリンによる免疫調節療法の開発
- 2019 - 2022 Alteration of transcription network via super-enhancer in acute leukemia
Papers (80)：
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Yoshihiro Yokota, Takayuki Imai, Masahiro Kawahara, Osamu Inatomi, Atsushi Nishida, Yoichi Kakuta, Atsushi Masamune, Akira Andoh. Thiopurines exert harmful effects on spermatogenesis in Nudt15R138C knock-in mice. Journal of gastroenterology. 2024. 59. 2. 109-118
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Ai Asai-Nishishita, Masahiro Kawahara, Goichi Tatsumi, Masaki Iwasa, Aya Fujishiro, Rie Nishimura, Hitoshi Minamiguchi, Katsuyuki Kito, Makoto Murata, Akira Andoh. FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells. Scientific reports. 2023. 13. 1. 14454-14454
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Noriaki Yamashita, Masahiro Kawahara, Takayuki Imai, Goichi Tatsumi, Ai Asai-Nishishita, Akira Andoh. Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells. Scientific reports. 2023. 13. 1. 11908-11908
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浅井 愛, 田代 晴加, 岩佐 磨佐紀, 雜賀 渉, 口分田 美奈, 永井 詩穂, 藤城 綾, 西村 理惠, 河原 真大, 南口 仁志, et al. 同種造血幹細胞移植後に発症した肝類洞閉塞症候群に対しdefibrotideによる治療が奏功した2症例. 日本造血・免疫細胞療法学会雑誌. 2022. 11. 2. 134-139
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阿部 和樹, 臼井 亜沙子, 川畑 徳浩, 岩佐 磨佐紀, 藤城 綾, 西村 理恵, 河原 真大, 南口 仁志, 木藤 克之, 安藤 朗. 難治性皮膚原発末梢性T細胞リンパ腫・非特定型に対して全身皮膚電子線照射が有効であった症例. 臨床血液. 2022. 63. 2. 149-149
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MISC (10)：
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今井 隆行, 河原 真大, 稲富 理, 角田 洋一, 安藤 朗. 小腸・IBD基礎研究の最前線 マウスモデルからみたNUDT15遺伝子多型と妊娠中のチオプリン服用. 日本小腸学会学術集会プログラム・抄録集. 2021. 59回. 53-53
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Kazuhisa Chonabayashi, Masahiro Kawahara, Akira Watanabe, Masahiro Nakamura, Masatoshi Nishizawa, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida. Ips Technology Revealed the Genetic and Functional Diversity Present in a Secondary AML Patient. BLOOD. 2016. 128. 22
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June Takeda, Hiroshi Kawabata, Kazunari Aoki, Shuichi Shiga, Masahiro Kawahara, Toshio Kitawaki, Masakatsu Hishizawa, Tadakazu Kondo, Toshiyuki Kitano, Noboru Yonetani, et al. Clinical Impact of Complex Karyotype, Monosomal Karyotype and Acquisition of Chromosomal Abnormalities in Patients with Myelodysplastic Syndromes. BLOOD. 2014. 124. 21
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Kazuhisa Chonabayashi, Masahiro Kawahara, Keisuke Okita, Masatoshi Nishizawa, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida. Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Maturation Defect of Myelodysplastic Syndromes. BLOOD. 2014. 124. 21
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Noriko Sugino, Masahiro Kawahara, Takayoshi Suzuki, Yuya Nagai, Yayoi Shimazu, Sumie Fujii, Ryusuke Yamamoto, Masakatsu Hishizawa, Akifumi Takaori-Kondo. The Pharmacological Inhibition of KDM1A Displays Preclinical Efficacy in AML and MDS By Inducing Myelomonocytic Differentiation. BLOOD. 2014. 124. 21
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Patents (1)：
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Lsd1-selective inhibitor having lysine structure
Professional career (1)：
Work history (2)：
- 2017/03 - 現在 Shiga University of Medical Science
- 2016/04 - 2017/02 Shiga University of Medical Science
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