Thumkeo Dean

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmacology

Research theme for competitive and other funds (6)：

2020 - 2023 T細胞皮質下アクチンの形成分子機構及びTCRシグナルにおける役割の解明
2019 - 2022 Epigenetic analysis and drug development with cell-reprogramming technology in atypical teratoid/rhabdoid tumor
2017 - 2020 Role of mDia, a polymerization factor, in Treg differentiation
2016 - 2019 Epigenomic analysis with reprogramming technology in lower grade glioma
2015 - 2017 Analysis of TCR signaling dependent mDia activation molecular mechanism

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Papers (24)：

Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin-ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, et al. Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice. FEBS Open Bio. 2024
Ratklao Siriwach, Anh Quynh Ngo, Shuh Narumiya, Dean Thumkeo. An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis. STAR protocols. 2022. 3. 4. 101906-101906
Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, Ryuma Matsuura, Kentaro Arima, Huan Nie, Rie Yamamoto, Naohiro Aoyama, Hisao Hamaguchi, Shingo Sugahara, et al. PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment. Cell reports. 2022. 39. 10. 110914-110914
Ratklao Siriwach, Anh Quynh Ngo, Makio Higuchi, Kentaro Arima, Satoko Sakamoto, Akira Watanabe, Shuh Narumiya, Dean Thumkeo. Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing. iScience. 2022. 25. 4. 104130-104130
Kimberly N Kremer, Alan Buser, Dean Thumkeo, Shuh Narumiya, Jordan Jacobelli, Roberta Pelanda, Raul M Torres. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 15. e2118816119

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MISC (3)：

Shuh Narumiya, Dean Thumkeo. Rho signaling research: history, current status and future directions. FEBS Letters. 2018. 592. 11. 1763-1776
上條博史, 松村裕, THUMKEO Dean, 清水良彦, 寺尾円香, 石崎敏理, 成宮周. ROCKの個体初期発生における役割. 生化学. 2007. 3P-0302
D Thumkeo, T Ishizaki, J Keel, K Kimura, M Oshima, MM Taketo, S Narumiya. Targeted disruption of the Rho-associated kinase 2 (mROCK-II) gene results in intrauterine growth retardation and fetal death. MOLECULAR BIOLOGY OF THE CELL. 2002. 13. 113A-114A

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