Kobayashi Akiko

Affiliation and department：

Research field (1)： Neuroscience - general

Research theme for competitive and other funds (3)：

2022 - 2025 アストロサイト形質転換の分子機序解明と創薬標的の探索
2019 - 2022 Identification of the mechanism inducing reactive astrocyte in neuroinflammatory condition as a therapeutic target.
2016 - 2019 Development of neurogenesis inducer for neurodegenerative disorders

Papers (12)：

Akiko Nakano-Kobayashi, Andres Canela, Toru Yoshihara, Masatoshi Hagiwara. Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway. Proceedings of the National Academy of Sciences. 2023
A. Nakano-Kobayashi, A. Fukumoto, A. Morizane, D. T. Nguyen, T. M. Le, K. Hashida, T. Hosoya, R. Takahashi, J. Takahashi, O. Hori, et al. Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation. Science Advances. 2020. 6. 46. eabc1428-eabc1428
Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM. DYRK1A and cognition: A lifelong relationship. Pharmacology & therapeutics. 2018. 194. 199-221
Kenji Ohe, Mayumi Yoshida, Akiko Nakano-Kobayashi, Motoyasu Hosokawa, Yukiya Sako, Maki Sakuma, Yukiko Okuno, Tomomi Usui, Kensuke Ninomiya, Takayuki Nojima, et al. RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomia. RNA. 2017. 23. 9. 1393-1403
Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya, Masatoshi Hagiwara. Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017. 114. 38. 10268-10273

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MISC (2)：

小林亜希子, 粟屋智就, 喜井勲, 隅田有人, 奥野友紀子, 和根崎圭子, 吉田優, 隅田ともえ, 井上治久, 細谷孝充, et al. 神経新生促進によるダウン症モデルにおける脳発達障害の是正. 生命科学系学会合同年次大会. 2017. 2017年度. [2AT26-1060)]
小林亜希子, 粟屋智就, 喜井勲, 隅田有人, 奥野友紀子, 和根崎圭子, 吉田優, 隅田ともえ, 井上治久, 細谷孝充, et al. 神経新生促進によるダウン症モデルにおける脳発達障害の是正. 日本生化学会大会(Web). 2017. 2017年度. [2P-10)]

Professional career (1)：

Work history (7)：

2023/04 - 現在 Kyoto University Graduate School of Medicine Associate Professor
2015/04 - 2023/03 Kyoto University Graduate School of Medicine Assistant Professor
2012/10 - 2015/03 Kyoto University Graduate School of Medicine Assistant Professor
2007/08 - 2012/09 Cold Spring Harbor Laboratory Postodoctoral Fellow
2006/04 - 2007/07 Tsukuba University Graduate School of Medicine Postodoctoral Fellow

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