Nagashima Shigeo

ナガシマシゲオ | Nagashima Shigeo

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60433116.ja.html

Research field (2)： Virology , Molecular biology

Research keywords (12)：分子ウイルス学 , E型肝炎ウイルス , 肝炎ウイルス , 下痢症ウイルス , ウイルス感染症 , 分子疫学 , 薬剤スクリーニング , 生物発光タンパク質 , 電子顕微鏡 , エクソソーム , 感染培養系 , 感染性cDNAクローン

Research theme for competitive and other funds (10)：

2022 - 2025 Identification of compounds that inhibit the early and late steps of hepatitis E virus infection and analysis of their inhibitory effects on the virus growth
2019 - 2022 Functional evaluation of the candidate proteins of hepatitis E virus receptor and identification of host factors involved in the permissibility of infection
2016 - 2019 Identification and functional analysis of host factors involved in early steps of hepatitis E virus infection
2013 - 2015 Research on mechanism of hepatitis E virus egress utilizing membrane traffic
2011 - 2012 Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

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Papers (113)：

Masaharu Takahashi, Tsutomu Nishizawa, Akira Nishizono, Manri Kawakami, Yukihiro Sato, Kazunori Kawakami, Masahiko Irokawa, Tomoko Tamaru, Shinichi Miyazaki, Mizuho Shimada, et al. Recent decline in hepatitis E virus prevalence among wild boars in Japan: Probably due to countermeasures implemented in response to outbreaks of classical swine fever virus infection. Virus research. 2024. 348. 199438-199438
Tatsuo Kanda, Tian-Cheng Li, Masaharu Takahashi, Shigeo Nagashima, Putu Prathiwi Primadharsini, Satoshi Kunita, Reina Sasaki-Tanaka, Jun Inoue, Atsunori Tsuchiya, Shingo Nakamoto, et al. Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
Putu Prathiwi Primadharsini, Shigeo Nagashima, Takashi Nishiyama, Hiroaki Okamoto. Three Distinct Reporter Systems of Hepatitis E Virus and Their Utility as Drug Screening Platforms. Viruses. 2023. 15. 10
Shigeo Nagashima, Putu Prathiwi Primadharsini, Takashi Nishiyama, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto. Development of a HiBiT-tagged reporter hepatitis E virus and its utility as an antiviral drug screening platform. JOURNAL OF VIROLOGY. 2023
Masaharu Takahashi, Satoshi Kunita, Tsutomu Nishizawa, Hiroshi Ohnishi, Putu Prathiwi Primadharsini, Shigeo Nagashima, Kazumoto Murata, Hiroaki Okamoto. Infection Dynamics and Genomic Mutations of Hepatitis E Virus in Naturally Infected Pigs on a Farrow-to-Finish Farm in Japan: A Survey from 2012 to 2021. VIRUSES-BASEL. 2023. 15. 7

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MISC (19)：

長嶋茂雄, プリマダルシニプトゥプラティウィ, 西山尚志, 高橋雅春, 村田一素, 岡本宏明. 発光タグHiBiTを保有する組換えE型肝炎ウイルスの開発と薬剤スクリーニングへの応用. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2022. 69th
小林富成, 高橋雅春, 長嶋茂雄, 西山尚志, PRIMADHARSINI Putu Prathiwi, 西澤勉, 岡本宏明. E型肝炎ワクチン開発に向けた大腸菌でのHEV(3型と4型)ORF2蛋白質の産生とウイルス様粒子の構築. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
プリマダルシニプトゥプラティウィ, 長嶋茂雄, 小林富成, 高橋雅春, 安田二朗, 岡本宏明. ラットE型肝炎ウイルスの感染細胞からの放出にはMVB sortingならびにエクソソーム分泌経路が重要である. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
大和田洋平, 大城幸雄, 稲垣勇紀, 高橋一広, 湯沢賢治, 大西浩史, 長嶋茂雄, 高橋雅春, 岡本宏明, 大河内信弘. わが国における心・腎移植患者のE型肝炎ウイルス感染の全国実態調査最終報告. 移植. 2018. 53. 総会臨時. 454-454
大和田洋平, 大城幸雄, 稲垣勇紀, 湯沢賢治, 大西浩史, 長嶋茂雄, 高橋雅春, 岡本宏明, 大河内信弘. わが国の心・腎移植患者におけるE型肝炎ウイルス感染の全国実態調査. 移植. 2017. 52. 総会臨時. 420-420

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Work history (2)：

2024/01 - 現在自治医科大学医学部准教授
2013 - Jichi Medical University School of Medicine

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