Usui-Kawanishi Fumitake

河西フミタケ | Usui-Kawanishi Fumitake

Affiliation and department：

Research field (2)： Animal production science , Cardiology

Research keywords (8)：バイオ医薬品 , タンパク質工学 , 発生工学 , 始原生殖細胞 , ニワトリ , メタボリック症候群 , 炎症 , 自然免疫

Research theme for competitive and other funds (13)：

2019 - 2022 Development of a novel biopharmaceutical production method via chicken eggs
2020 - 2021 迅速なNLRP3インフラマソーム活性化評価法の開発と制御物質の探索
2016 - 2020 Role of adapter molecule ASC independent of inflammasome
2017 - 2018 鶏卵を介した抗体医薬品産生法の開発
2017 - 2018 迅速なNLRP3インフラマソーム活性化検出法を利用した制御化合物の探索

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Papers (50)：

Fumitake Usui-Kawanishi, Koudai Kani, Tadayoshi Karasawa, Hiroe Honda, Nobuyuki Takayama, Masafumi Takahashi, Kiyoshi Takatsu, Yoshinori Nagai. Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Kaichi Kasai, Naoya Igarashi, Yuki Tada, Koudai Kani, Shun Takano, Tsutomu Yanagibashi, Fumitake Usui-Kawanishi, Shiho Fujisaka, Shiro Watanabe, Mayuko Ichimura-Shimizu, et al. Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice. International journal of molecular sciences. 2023. 24. 4
Yuki Tada, Kaichi Kasai, Nana Makiuchi, Naoya Igarashi, Koudai Kani, Shun Takano, Hiroe Honda, Tsutomu Yanagibashi, Yasuharu Watanabe, Fumitake Usui-Kawanishi, et al. Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis. International journal of molecular sciences. 2022. 23. 21
Sachiko Watanabe, Fumitake Usui-Kawanishi, Takanori Komada, Tadayoshi Karasawa, Ryo Kamata, Naoya Yamada, Hiroaki Kimura, Katsuya Dezaki, Tsukasa Ohmori, Masafumi Takahashi. ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome. Biochemical and biophysical research communications. 2020. 531. 2. 125-132
Sachiko Watanabe, Fumitake Usui-Kawanishi, Tadayoshi Karasawa, Hiroaki Kimura, Ryo Kamata, Takanori Komada, Yoshiyuki Inoue, Nathan Mise, Tadashi Kasahara, Masafumi Takahashi. Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages. Journal of cellular physiology. 2020. 235. 10. 7554-7566

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MISC (9)：

白砂孔明, 唐澤直義, 臼井文武, 木村博昭, 川島晃, 大口昭英, 岩田尚孝, 桑山岳人, 高橋将文. AngiotensinII誘導性妊娠高血圧腎症におけるインフラマソーム構成分子の役割. Reproductive Immunology and Biology. 2015. 30. 1-2. 113-113
K. Shirasuna, F. Usui, T. Karasawa, H. Kimura, A. Kawashima, H. Mizukami, A. Ohkuchi, M. Takahashi. Nanosilica-induced placental inflammation and pregnancy complications: different roles of the inflammasome components NLRP3 and ASC. JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014. 106. 14-14
Masafumi Takahashi, Fumitake Usui, Akira Kawashima, Tadayoshi Karasawa, Hiroaki Kimura. Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II-induced Aortic Aneurysm. CIRCULATION. 2014. 130
白砂孔明, 臼井文武, 唐澤直義, 木村博昭, 川島晃, 水上浩明, 大口昭英, 高橋将文. ナノ粒子による妊娠機能異常の機序自然炎症インフラマソーム機構の関与の可能性. Reproductive Immunology and Biology. 2014. 29. 1-2. 84-84
白砂孔明, 臼井文武, 唐澤直義, 木村博昭, 川島晃, 大口昭英, 高橋将文. ナノ粒子は妊娠マウスの胎盤炎症と妊娠機能異常を引き起こす自然炎症経路・インフラマソームの関与. The Journal of Reproduction and Development. 2014. 60. Suppl. j94-j94

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Lectures and oral presentations (14)：

動脈硬化および血管炎症におけるカスパーゼ-1の役割
(血管 2013)
腹部大動脈瘤形成におけるインフラマソームの役割の解明
(日本内分泌学会雑誌 2012)
動脈硬化の形成におけるインフラマソームの役割
(肥満研究 2011)
動脈硬化の形成におけるIL-17の役割
(肥満研究 2011)
ニワトリ骨髄細胞による血管再生 ([日本家禽学会2010年度]秋季大会号)
(日本家禽学会誌 2010)

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Professional career (1)：

博士(農学) (信州大学)

Work history (2)：

2017/04 - 現在 Toyama Prefectural University
2013/04 - 2016/03 Jichi Medical University School of Medicine

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