Rchr
J-GLOBAL ID:201401010422554614   Update date: Feb. 05, 2025

Sugiyama Hiroshi

スギヤマ ヒロシ | Sugiyama Hiroshi
Affiliation and department:
Job title: Researcher
Homepage URL  (1): http://kuchem.kyoto-u.ac.jp/chembio/
Research field  (1): Biochemistry
Research keywords  (2): 核酸化学 ,  ケミカルバイオロジー
Research theme for competitive and other funds  (56):
  • 2022 - 2025 CROX: Construction of tumor immunity / metastasis control strategy by suppressing RUNX
  • 2021 - 2025 A novel strategy for molecular diagnosis and prophylactic approach to non-syndromic cleft palate
  • 2020 - 2025 Modality of nucleosome dynamics
  • 2021 - 2024 遺伝子ネットワークを制御する分子の開発と細胞への応用
  • 2020 - 2023 A novel strategy for dentin regeneration by transcriptional regulation of Runx2
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Papers (596):
  • Katsuhiko Abe, Haruhiko Eki, Yuki Hirose, Soyoung Park, Shanmugavel Chinnathambi, Ganesh Pandian Namasivayam, Kazuki Takeda, Hiroshi Sugiyama, Masayuki Endo. Creation of Metal-Complex-Integrated Tensegrity Triangle DNA Crystals. Molecules. 2024. 29. 19. 4674-4674
  • Deepak Karna, Lin Liang, Grinsun Sharma, Shankar Mandal, Sefan Asamitsu, Yusuke Kawamoto, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama, Hanbin Mao. Modulation of dynamic DNA G-quadruplex structures in the hTERT promoter region by ligands. Nucleic Acids Research. 2024
  • Yuki Hirose, Shinsuke Sato, Kaori Hashiya, Mitsuharu Ooga, Toshikazu Bando, Hiroshi Sugiyama. Chb-M', an Inhibitor of the RUNX Family Binding to DNA, Induces Apoptosis in p53-Mutated Non-Small Cell Lung Cancer and Inhibits Tumor Growth and Repopulation In Vivo. Journal of medicinal chemistry. 2024
  • Katsuhiko Abe, Yuki Hirose, Tomotaka Kumagai, Kaori Hashiya, Kumi Hidaka, Tomoko Emura, Toshikazu Bando, Kazuki Takeda, Hiroshi Sugiyama. Structural Studies of a Complex of a CAG/CTG Repeat Sequence-Specific Binding Molecule and A-A-Mismatch-Containing DNA. JACS Au. 2024. 4. 5. 1801-1810
  • Mitsuharu Ooga, Vinodh Sahayasheela, Yuki Hirose, Daisuke Sasaki, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama. A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures. Chemical Communications. 2024
more...
MISC (239):
  • Vinodh J. Sahayasheela, 杉山 弘. ミトコンドリアとグアニン四重鎖の進化. 化学 = Chemistry. 2023. 78. 4. 34-38
  • 増田 達哉, 窪田 博仁, 櫻本 直也, 秦 明日香, 堀内 彩香, 佐々木 亜沙美, 武田 佳那子, 武田 瑞穂, 松尾 英将, 平田 勝啓, et al. AMLおよびGVHDの新しい治療標的としてのRUNX-NFAT軸の重要性(The importance of RUNX-NFAT axis as a novel therapeutic target for AML and GVHD). 日本血液学会学術集会. 2021. 83回. OS2-4
  • Etsuko Y. Hattori, Yoshiki Arakawa, Youhei Mineharu, Masamitsu Mikami, Yasuzumi Matsui, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo. Suppression of glioblastoma through novel drug based on 'Gene Switch Technology'. CANCER SCIENCE. 2021. 112. 465-465
  • Ryu Tashiro, Hiroshi Sugiyama. Photoreaction of DNA Containing 5-Halouracil and its Products†. Photochemistry and Photobiology. 2021
  • 増田 達哉, 窪田 博仁, 櫻本 直也, 秦 明日香, 堀内 彩香, 佐々木 亜沙美, 武田 佳那子, 武田 瑞穂, 松尾 英将, 杉山 弘, et al. 急性骨髄性白血病およびT細胞性免疫の新規治療標的としてのRUNX-NFATアキシス. 日本癌学会総会記事. 2020. 79回. OE14-4
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Patents (5):
  • ピロール-イミダゾールポリアミド化合物群を用いた内在性制御因子のスクリーニング方法
  • RUNX阻害剤
  • 特定遺伝子の発現を活性化するCTB-PIポリアミドコンジュゲート
  • ドライバーオンコジーンの遺伝子変異を標的にアルキル化する新規アルキル化剤
  • 標的遺伝子特異的ヒストン修飾制御剤
Books (4):
  • 基礎ケミカルバイオロジー
    化学同人 2011 ISBN:9784759814705
  • ウィーバー分子生物学(第4版)
    化学同人 2008 ISBN:9784759811568
  • ゲノム化学ー医学、分子生物学への応用と展開
    化学同人 2007 ISBN:9784759807486
  • 生命化学のニューセントラルドグマーテーラーメイド・バイオケミストリーのめざすもの
    化学同人 2002 ISBN:4759807357
Lectures and oral presentations  (51):
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (IUPAC International Symposium on Bioorganic Chemistry (ISBOC-12), Tsinghua Shenzhen International School (Tsinghua SIGS), Shenzhen, China 2019)
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (The 10th International Symposium, Interdisciplinary Science and Technology Innovations for Sustainable Society, Osaka University Hall, Toyonaka, Osaka, Japan 2019)
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (The K. T. Wang Bioorganic Chemistry Foundation Lecture, National Biotechnology Research Park, Taipei, Taiwan 2019)
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (2019 KSBB Fall Meeting and International Symposium: Biotechnology from the Nature to Human Life, EXCO, Daegu, Korea 2019)
  • Chemical Biology of Nucleic: DNA Origami and Artificial Genetic Switch
    (Asia 3 Roundtable of Nucleic Acids (A3RONA 2019), Jibasan Building, Himeji, Japan 2019)
more...
Education (3):
  • 1981 - 1984 Kyoto University Graduate School of Engineering
  • 1979 - 1981 Kyoto University Graduate School of Engineering
  • 1975 - 1979 Kyoto University Faculty of Engineering
Professional career (1):
  • PhD (Kyoto University)
Work history (9):
  • 2022/04 - 現在 物質ー細胞統合システム拠点 特任教授
  • 2003/04 - 2022/03 Kyoto University Graduate School of Science
  • 2008/04 - 2018/03 Kyoto University
  • 1999/04 - 2003/03 Tokyo Medical and Dental University Institute of Biomaterials and Bioengineering
  • 1996/11 - 1999/03 Tokyo Medical and Dental University
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Committee career (13):
  • 2021/05 - 現在 近畿化学協会 会長
  • 2017 - 現在 Bull. Chem. Soc. J. Associate Editor
  • 2016 - 現在 Cell, Chemical Biology Editorial Advisory Board
  • 2014 - 現在 Scientific Reports Editorial Board
  • 2010 - 現在 近畿化学協会 理事
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Awards (6):
  • 2022/08 - 日本光生物学協会 協会賞
  • 2021/11 - The Japan Society of Nucleic Acids Chemistry Ikehara Award
  • 2018/07 - 日本光医学・光生物学会 学会賞
  • 2018/03 - 日本化学会 日本化学会賞
  • 2005/03 - 日本化学会 学術賞
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Association Membership(s) (10):
アメリカ化学会 ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  KINKI CHEMICAL SOCIETY, JAPAN ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE JAPANESE CANCER ASSOCIATION ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  日本光医学・光生物学会
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