Rchr
J-GLOBAL ID：201401010422554614   Update date: Sep. 29, 2024

Sugiyama Hiroshi

スギヤマ ヒロシ | Sugiyama Hiroshi
Affiliation and department：
Kyoto University Graduate School of Science Division of Chemistry

About Kyoto University Graduate School of Science Division of Chemistry


Other affiliations (1)：
  • 物質-細胞統合システム拠点  主任研究員(併任)
Homepage URL  (1)： http://kuchem.kyoto-u.ac.jp/chembio/
Research field  (1)： Biochemistry
Research keywords  (2)： 核酸化学 ,  ケミカルバイオロジー
Research theme for competitive and other funds  (56)：
  • 2022 - 2025 CROX: Construction of tumor immunity / metastasis control strategy by suppressing RUNX
  • 2021 - 2025 A novel strategy for molecular diagnosis and prophylactic approach to non-syndromic cleft palate
  • 2020 - 2025 Modality of nucleosome dynamics
  • 2021 - 2024 遺伝子ネットワークを制御する分子の開発と細胞への応用
  • 2020 - 2023 A novel strategy for dentin regeneration by transcriptional regulation of Runx2
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Papers (591)：
  • Deepak Karna, Lin Liang, Grinsun Sharma, Shankar Mandal, Sefan Asamitsu, Yusuke Kawamoto, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama, Hanbin Mao. Modulation of dynamic DNA G-quadruplex structures in the hTERT promoter region by ligands. Nucleic Acids Research. 2024
  • Yuki Hirose, Shinsuke Sato, Kaori Hashiya, Mitsuharu Ooga, Toshikazu Bando, Hiroshi Sugiyama. Chb-M', an Inhibitor of the RUNX Family Binding to DNA, Induces Apoptosis in p53-Mutated Non-Small Cell Lung Cancer and Inhibits Tumor Growth and Repopulation In Vivo. Journal of medicinal chemistry. 2024
  • Katsuhiko Abe, Yuki Hirose, Tomotaka Kumagai, Kaori Hashiya, Kumi Hidaka, Tomoko Emura, Toshikazu Bando, Kazuki Takeda, Hiroshi Sugiyama. Structural Studies of a Complex of a CAG/CTG Repeat Sequence-Specific Binding Molecule and A-A-Mismatch-Containing DNA. JACS Au. 2024. 4. 5. 1801-1810
  • Mitsuharu Ooga, Vinodh Sahayasheela, Yuki Hirose, Daisuke Sasaki, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama. A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures. Chemical Communications. 2024
  • Yusuke Kawamoto, You Wu, Soyoung Park, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura. Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effect. Chemical Communications. 2024
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MISC (236)：
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Patents (5)：
  • ピロール-イミダゾールポリアミド化合物群を用いた内在性制御因子のスクリーニング方法
  • RUNX阻害剤
  • 特定遺伝子の発現を活性化するCTB-PIポリアミドコンジュゲート
  • ドライバーオンコジーンの遺伝子変異を標的にアルキル化する新規アルキル化剤
  • 標的遺伝子特異的ヒストン修飾制御剤
Books (4)：
  • 基礎ケミカルバイオロジー
    化学同人 2011 ISBN:9784759814705
  • ウィーバー分子生物学(第4版)
    化学同人 2008 ISBN:9784759811568
  • ゲノム化学ー医学、分子生物学への応用と展開
    化学同人 2007 ISBN:9784759807486
  • 生命化学のニューセントラルドグマーテーラーメイド・バイオケミストリーのめざすもの
    化学同人 2002 ISBN:4759807357
Lectures and oral presentations  (51)：
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (IUPAC International Symposium on Bioorganic Chemistry (ISBOC-12), Tsinghua Shenzhen International School (Tsinghua SIGS), Shenzhen, China 2019)
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (The 10th International Symposium, Interdisciplinary Science and Technology Innovations for Sustainable Society, Osaka University Hall, Toyonaka, Osaka, Japan 2019)
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (The K. T. Wang Bioorganic Chemistry Foundation Lecture, National Biotechnology Research Park, Taipei, Taiwan 2019)
  • Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switches
    (2019 KSBB Fall Meeting and International Symposium: Biotechnology from the Nature to Human Life, EXCO, Daegu, Korea 2019)
  • Chemical Biology of Nucleic: DNA Origami and Artificial Genetic Switch
    (Asia 3 Roundtable of Nucleic Acids (A3RONA 2019), Jibasan Building, Himeji, Japan 2019)
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Education (3)：
  • 1981 - 1984 Kyoto University Graduate School of Engineering
  • 1979 - 1981 Kyoto University Graduate School of Engineering
  • 1975 - 1979 Kyoto University Faculty of Engineering
Professional career (1)：
  • PhD (Kyoto University)
Work history (9)：
  • 2022/04 - 現在 物質ー細胞統合システム拠点 特任教授
  • 2003/04 - 2022/03 Kyoto University Graduate School of Science
  • 2008/04 - 2018/03 Kyoto University
  • 1999/04 - 2003/03 Tokyo Medical and Dental University Institute of Biomaterials and Bioengineering
  • 1996/11 - 1999/03 Tokyo Medical and Dental University
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Committee career (13)：
  • 2021/05 - 現在 近畿化学協会 会長
  • 2017 - 現在 Bull. Chem. Soc. J. Associate Editor
  • 2016 - 現在 Cell, Chemical Biology Editorial Advisory Board
  • 2014 - 現在 Scientific Reports Editorial Board
  • 2010 - 現在 近畿化学協会 理事
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Awards (6)：
  • 2022/08 - 日本光生物学協会 協会賞
  • 2021/11 - The Japan Society of Nucleic Acids Chemistry Ikehara Award
  • 2018/07 - 日本光医学・光生物学会 学会賞
  • 2018/03 - 日本化学会 日本化学会賞
  • 2005/03 - 日本化学会 学術賞
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Association Membership(s) (10)：
アメリカ化学会 ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  KINKI CHEMICAL SOCIETY, JAPAN ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE JAPANESE CANCER ASSOCIATION ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  日本光医学・光生物学会
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