Kouichi Matsuda

Matsuda Koichi | Kouichi Matsuda

Affiliation and department：
Job title：教授
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/90401257.ja.html

Research field (5)： Genomics , Tumor diagnostics and therapeutics , Cell biology , Gastroenterology , Urology

Research keywords (9)： bone and soft tissue tumor , biobank , p53 , ゲノムワイド関連解析 , 遺伝子多型 , 細胞老化 , バイオマーカー , 癌抑制遺伝子 , シトルリン化

Research theme for competitive and other funds (22)：

2024 - 2028 脳卒中のAI画像解析とポリジェニックモデルによる関連遺伝子座の相関性分析
2022 - 2025 骨軟部腫瘍全ゲノム解析データに基づく遺伝子異常の機能解析と治療標的の同定
2020 - 2025 Development of personalized soft tissue sarcoma therapies through the integrated genomic analysis
2020 - 2025 Development of personalized soft tissue sarcoma therapies through the integrated genomic analysis
2021 - 2024 本邦における脳梗塞関連遺伝子座と臨床的特徴に関する検討

2018 - 2023 希少がんである脊索腫における腫瘍原生並びに治療標的となるゲノム変異の探索

2019 - 2022 Identification of functional variants by comprehensive analysis of coding variants for the implementation of genomic medicine

2019 - 2022 Significance of the inflammatory cascade within vascular wall of the cerebral aneurysms formation

2017 - 2021 デスモイド型線維腫症の病態に基づく診断、新規治療開発への学際的・国際的共同研究

2017 - 2021 Genomic analysis for detecting therapeutic targets in clear cell sarcoma

2016 - 2021 Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma

2016 - 2018 p53制御経路の網羅的解析による腫瘍細胞の特性の解明と治療法の開発

2015 - 2018 Identification of cancer-related gene polymorphisms by genetic integration of mouse and human

2013 - 2016 Personalized medicine for patients with Helicobacter pylori infection

2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

2013 - 2015 p53による時間、空間的な遺伝子発現制御機構の解明

2011 - 2015 Integrated elucidation of the urinary stone formation mechanism considered from heredity and environment factors, and development of the new therapeutic medicines

2012 - 2013 慢性B型肝炎・疾感関連遺伝子の解析

2011 - 2012 Genome wide association analysis of age at menarche, menopause and menses cycle

2010 - 2012 Role of p53-citrullination in human carcinogenesis

2011 - 2011 Evaluation of MICA variations and serum MICA as prognostic factors for Chronic hepatitis C patients

2006 - 2008 Identification and functional analysis of novel p53 target genes related to cellular senescence.

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Papers (341)：

Kenichi Yamamoto, Shinichi Namba, Kyuto Sonehara, Ken Suzuki, Saori Sakaue, Niall P Cooke, Shinichi Higashiue, Shuzo Kobayashi, Hisaaki Afuso, Kosho Matsuura, et al. Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations. Nature communications. 2024. 15. 1. 9780-9780
Shinichi Namba, Masato Akiyama, Haruka Hamanoue, Kazuto Kato, Minae Kawashima, Itaru Kushima, Koichi Matsuda, Masahiro Nakatochi, Soichi Ogishima, Kyuto Sonehara, et al. Inconsistent embryo selection across polygenic score methods. Nature human behaviour. 2024
Masatoshi Matsunami, Minako Imamura, Asuka Ashikari, Xiaoxi Liu, Kohei Tomizuka, Keiko Hikino, Kosei Miwa, Katsumi Kadekawa, Tetsuji Suda, Koichi Matsuda, et al. Genome-wide association studies for pelvic organ prolapse in the Japanese population. Communications biology. 2024. 7. 1. 1188-1188
Tatsuhiko Naito, Kosuke Inoue, Shinichi Namba, Kyuto Sonehara, Ken Suzuki, Koichi Matsuda, Naoki Kondo, Tatsushi Toda, Toshimasa Yamauchi, Takashi Kadowaki, et al. Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores. Communications Medicine. 2024. 4. 1
Kyuto Sonehara, Yoshitaka Yano, Tatsuhiko Naito, Shinobu Goto, Hiroyuki Yoshihara, Takahiro Otani, Fumiko Ozawa, Tamao Kitaori, Yuji Yamanashi, Yoichi Furukawa, et al. Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss. Nature Communications. 2024. 15. 1

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MISC (69)：

平井利英, 平田真, 川井章, 比留間徹, 菊田一貴, 吉田朗彦, 小林寛, 柴田龍弘, 田中栄, 松田浩一. 骨・軟部肉腫の全ゲノム,トランスクリプトーム解析先行解析. 日本整形外科学会雑誌. 2023. 97. 6. S1449-S1449
Mingyang Shi, Chizu Tanikawa, Hans Markus Munter, Masato Akiyama, Satoshi Koyama, Kohei Tomizuka, Koichi Matsuda, Gregory Mark Lathrop, Chikashi Terao, Masaru Koido, et al. Characterizing the quality metric in genotype imputation. bioRxiv. 2023
Yunye He, Masaru Koido, Yoichi Sutoh, Mingyang Shi, Yayoi Otsuka-Yamasaki, Hans Markus Munter, Takayuki Morisaki, Akiko Nagai, Yoshinori Murakami, Chizu Tanikawa, et al. East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease. medRxiv. 2022. 55. 12. 2129-2138
鶴裕美, 谷川千津, 鷺谷洋司, 松田浩一. Association of SNP within p53 binding motif with a prostate cancer risk. 日本癌学会学術総会抄録集(Web). 2022. 81st
関根悠哉, 平田真, 鎌谷洋一郎, 松田浩一, 菅野康吉, 吉田輝彦, 村上善則, 赤松秀輔, 小川修, 沼倉一幸, et al. 腎がんの組織型に寄与する遺伝子が異なることを示した大規模ゲノム解析. 日本泌尿器科学会総会. 2021. 109回. AOP03-05

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Lectures and oral presentations (48)：

Identification of an novel genetic variant associated with osteoporosis: insights from the Taiwan Biobank Study.
(JBMR plus 2024)
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
(Nature communications 2024)
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
(Nature 2024)
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses.
(Cancer communications (London, England) 2024)
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.
(Nature communications 2024)

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Professional career (1)：

医学博士 (東京大学)

Work history (3)：

2016/07 - 現在 The University of Tokyo Graduate School of Frontier Sciences
2010 - 2016/06 The University of Tokyo The Institute of Medical Science
2004/06 - 2010 東京大学医科学研究所助教

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