2018 - 2021 Molecular basis for KIR ligand-mismatched cord blood transplantation for advanced neuroblastoma
2017 - 2021 Development for a new histobiological risk stratification and establishing of genomic medicine for pediatric malignant solid tumors
2017 - 2019 iPS-derived differentiation-related tumor models and multi-omics analysis
2016 - 2019 Single cell screening of molecular target in using malignant neuroblastoma animal model
2014 - 2018 Development of novel therapeutic methods targeting human CD133-positive neuroblastoma stem cells
2014 - 2017 Unveiling the mechanism of recurrence and chemoresistance in neuroblastoma using genomewide and epigenomewide analysis
2014 - 2017 Functional analysis of PTPRK-CD133 regulatory axis in colon cancer progression.
2013 - 2016 A novel therapeutic targeting of CD133 transcription in malignant neuroblastoma
2012 - 2015 Basic Research on Gastrointestinal Cancer Stem Cell Targeting Therapy with Heavy Ion Beams
2012 - 2015 Molecular mechanisms behind the acquisition of multi-drug resistance in sphere-formed colon cancer cells.
2012 - 2015 Development of cancer stem cell-targeted therapy by study of tumor sphere formation mechanism using comprehensive and genetic approach
2011 - 2013 Development of a novel therapeutic approach for pediatric malignant solid tumors using NKT cell-mediated immune system
2010 - 2012 Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
2009 - 2011 Screening of polycomb Bmi1 targets for development of Cancer Stem Cell-targeted therapy for neuroblastoma
2007 - 2008 Epigenetic modification in pediatric malignancies:Analysis of chromatin regulation by Polycomb proteins
2007 - 2008 Functional analysis of cell death in neuroblastoma by dependence receptor, UNC5H4
2005 - 2007 Epigenetic regulation of proliferation and differentiation of hematopoietic stem cells
2005 - 2006 Investigation of new molecular target of neuroblastoma therapy: The role of p53 pathway in neuroblastoma cell death
2001 - 2005 Molecular mechanisms that integrate 'cell death and cell cycle progression.
2003 - 2004 Epigenetic regulation of p15 mRNA expression in juvenile myelomonocytic
2003 - 2004 Investigation of a new molecular target-based treatment of caneer-drug resistant pediatric solid tumors
2002 - 2004 Clinical and molecular analysis of childhood cancer after Chernobyl
2001 - 2004 Analysis of Molecular Mechanism of ARF-dependent apoptotic cell death
2000 - 2004 Fuctinonal analysis of cancer related genes by targeted mutagenesis in mice
2001 - 2002 Identification of transcription factor specific for human mast cells
2000 - 2001 Analysis of the mechanism for suppression of childhood leukemia via ARF-p53 pathway
1999 - 2000 Regulatory system of human mast cell production
1997 - 1999 Study of childhood leukemia after Chernobyl
1995 - 1995 乳児突然死をきたすミトコンドリア脂肪酸β酸化酵素欠損症の遺伝子解析
1994 - 1995 Effect of the Chernobyl accident on tumor-surveillance system and hematopoiesis in children.
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Papers (164)：
Ryu Okada, Hisanori Takenobu, Shunpei Satoh, Ryuichi P. Sugino, Ritsuko Onuki, Masayuki Haruta, Kyosuke Mukae, Atsuko Nakazawa, Jesmin Akter, Miki Ohira, et al. L3MBTL2 maintains MYCN-amplified neuroblastoma cell proliferation through silencing NRIP3 and BRME1 genes. Genes to Cells. 2024
HIROTAKA FUCHIZAWA, KIYOHIRO ANDO, NORIKO MOTOI, TOSHIHIKO IIZUKA, MASAHARU INOUE, KOUKI MITANI, YUTA SANO, HISANORI TAKENOBU, MASAYUKI HARUTA, RITSUKO ONUKI, et al. STAT3 Contributes a Favorable Response to Pembrolizumab Through IFN-γ-induced Apoptosis in Urothelial Cancer. Anticancer Research. 2024. 44. 5. 1925-1930
Akihiro Yoneda, Hiroyuki Shichino, Tomoro Hishiki, Kimikazu Matsumoto, Miki Ohira, Takehiko Kamijo, Tatsuo Kuroda, Toshinori Soejima, Atsuko Nakazawa, Tetsuya Takimoto, et al. A nationwide phase II study of delayed local treatment for children with high-risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN-H-11. Pediatric blood & cancer. 2024. e30976
Kyosuke Mukae, Osamu Takei, Fumi Imai, Takehiko Kamijo. Development of RNA/DNA automated extraction and purification device for infectious disease diagnosis. Practical Laboratory Medicine. 2023
Noriyuki Nishimura, Toshiaki Ishida, Isao Yokota, Kimikazu Matsumoto, Hiroyuki Shichino, Hiroyuki Fujisaki, Takeo Sarashina, Takehiko Kamijo, Tetsuya Takimoto, Tomoko Iehara, et al. Minimal Residual Disease Detected by the 7NB-mRNAs ddPCR Assay Is Associated with Disease Progression in High-Risk Neuroblastoma Patients: A Prospective Multicenter Observational Study in Japan. Biology. 2023. 12. 10
