Yamakado Hodaka

Affiliation and department：
Job title： Research Associate Professor

Research field (1)： Neurology

Research keywords (6)：プリオン , α-シヌクレイン , バイオマーカー , 動物モデル , 多系統萎縮症 , パーキンソン病

Research theme for competitive and other funds (11)：

2023 - 2026 Basic technology of lipid membrane immunosensor for detection of pathogenic protein in blood contributing to ultra-early diagnosis of dementia
2023 - 2025 Elucidation of the pathogenesis and development of disease-modifying therapies targeting neurodegenerative disorders by proteolytic system
2020 - 2024 パーキンソン病関連疾患のモデル作製と治療薬開発
2020 - 2024 Fundamental study on bioelectronic chip for diagnosis of pathologic conditions based on specific and ultrahighly sensitive detection of prion-like protein
2020 - 2023 Investigation of the pathogenesis and the development of therapeutics of neurodegenerative disorders with cell-type specific liposome and exosome

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Papers (71)：

Yusuke Sakato, Atsushi Shima, Yuta Terada, Kiyoaki Takeda, Haruhi Sakamaki-Tsukita, Akira Nishida, Kenji Yoshimura, Ikko Wada, Koji Furukawa, Daisuke Kambe, et al. Delineating three distinct spatiotemporal patterns of brain atrophy in Parkinson's disease. Brain : a journal of neurology. 2024
Akira Nishida, Atsushi Shima, Daisuke Kambe, Koji Furukawa, Haruhi Sakamaki-Tsukita, Kenji Yoshimura, Ikko Wada, Yusuke Sakato, Yuta Terada, Masanori Sawamura, et al. Frontoparietal-Striatal Network and Nucleus Basalis Modulation in Patients With Parkinson Disease and Gait Disturbance. Neurology. 2024. 103. 3. e209606
Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado. A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy. Molecular Brain. 2024. 17. 1
Hodaka Yamakado, Ryosuke Takahashi. Experimental Animal Models of Prodromal Parkinson's Disease. Journal of Parkinson's disease. 2024
渡部美佳, 島淳, 武田清明, 坂戸勇介, 寺田祐太, 酒巻春日, 澤村正典, 中西悦郎, 山門穂高, 高橋良輔, et al. パーキンソン病患者の治療選択に関する意識調査デバイス補助療法を受けた患者の検討. 臨床神経学. 2023. 63. Suppl. S378-S378

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MISC (10)：

E. Nakanishi, N. Uemura, H. Akiyama, M. Kinoshita, H. Yamakado, S. Takeda, Y. Hirabayashi, R. Takahashi. Is the GBA2 a new modifier for Gauchers's disease and GBA1-related Parkinson's disease?. MOVEMENT DISORDERS. 2017. 32
引網亮太, 端祐一郎, 山門穂高, 辰己新水, 山下博史, 澤本伸克, 辻輝之, 川本未知, 幸原伸夫, 井上治久, et al. FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像:若年発症例を含む4症例の検討. 56th Annual Meeting of the Japanese Society of Neurology, Niigata. 2015
Yasushi Koshiba, Hodaka Yamakado, Asuka Morizane, Tetsuhiro Kikuchi, Kazuko Hasegawa, Haruhisa Inoue, Jun Takahashi, Ryosuke Takahashi. iPS cell modeling of genetic Parkinson's disease. MOVEMENT DISORDERS. 2014. 29. S68-S68
N. Uemura, H. Matsui, T. Fujiwara-Ishikawa, M. Kinoshita, M. Koike, H. Yamakado, K. Uemura, Y. Uchiyama, T. Todo, S. I. Takeda, et al. Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain. MOVEMENT DISORDERS. 2013. 28. S373-S374
H. Yamakado, Y. Moriwaki, N. Yamasaki, T. Miyakawa, J. Kurisu, K. Uemura, H. Inoue, M. Takahashi, R. Takahashi. alpha-synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior. MOVEMENT DISORDERS. 2012. 27. S498-S498

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Lectures and oral presentations (15)：

神経変性疾患における中枢-末梢病態連関
(第46回神経科学大会(シンポジウム) 2023)
パーキンソン病に伴う自律神経障害
(第75回日本自律神経学会総会(シンポジウム) 2022)
Animal model for Parkinson's disease: Strengths and drawbacks
(UK-Japan Neuroscience Symposium 2022)
多系統萎縮症の病態はどこまで分かったか?
(第16回MDSJ(教育講演) 2022)
Animal model of Parkinson's disease: For unveiling the pathogenesis and the develpment of DMT
(2022)

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Education (2)：

Professional career (1)：

Work history (8)：

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